MRI characteristics for differentiating mucinous borderline ovarian tumours from mucinous ovarian cancers

2021 ◽  
Author(s):  
X.Y. Yang ◽  
X. Li ◽  
F.H. Ma ◽  
H.M. Li ◽  
S.H. Zhao ◽  
...  
Keyword(s):  
Ovarian Cancers ◽  
Ovarian Tumours ◽  
Mri Characteristics

Differentiation between endometriosis-associated ovarian cancers and non- endometriosis-associated ovarian cancers based on magnetic resonance imaging

2021 ◽  
pp. 20201441
Author(s):  
Ximing Zhang ◽  
Min Li ◽  
Zhuopeng Tang ◽  
Xinyi Li ◽  
Ting Song
Keyword(s):  
Regression Analysis ◽  
Clinical Characteristics ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Maximum Diameter ◽  
Mri Findings ◽  
Ovarian Cancers ◽  
Imaging Characteristics ◽  
Mri Characteristics ◽  
Mural Nodules

Objectives: Endometriosis-associated ovarian cancer (EAOC) patients show different clinical characteristics compared with non-EAOC patients. However, a few studies are focused on the imaging characteristics of EAOC until now. We assessed MRI characteristics in differentiating EAOC and non-EAOC. Methods: We retrospectively analyzed clinical and MRI characteristics from 54 patients with 67 lesions diagnosed with primary epithelial ovarian carcinoma at the Third Affiliated Hospital of Guangzhou Medical University between January 2012 and October 2020. We studied MRI findings such as maximum diameter, morphology, configuration, locularity, features of mural nodules, lymphadenopathy, peritoneal implants, the presence of hyperintensity on T1WI, and hypointensity on T2WI. We also studied the clinical characteristics. Significant MRI variables in univariate analysis were selected for subsequent multivariate regression analysis. This study evaluated the diagnostic performance of the significant MRI variables in univariate analysis. Results: We found that the patients with EAOC, compared with those with non-EAOC, were younger, more unilateral, and had earlier FIGO stage. Univariate analysis revealed that morphology, locularity, growth pattern of mural nodules, and hypointensity on T2WI were factors that significantly differed between EAOC and non-EAOC. In the multivariate logistic regression analysis, locularity and hypointensity on T2WI were independent predictors to distinguish EAOC from non-EAOC. Conclusions: EAOC typically presented as a unilocular mass with hypointensity on T2WI in cystic components. MRI could help distinguish EAOC from non-EAOC. Advances in knowledge: MRI is a promising tool for preoperative diagnosis of EAOC.

Immunoexpression of Epidermal Growth Factor Receptor (EGFR) in Malignant Surface Epithelial Tumours of Ovary

2019 ◽  
Vol 31 (3) ◽  
pp. 219-225
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Clear Cell ◽  
Growth Factor Receptor ◽  
Ovarian Cancers ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Poorly Differentiated ◽  
Epidermal Growth ◽  
Epithelial Ovarian Tumours ◽  
Well Differentiated

Ovarian cancer is the deadliest gynaecological cancer and approximately 70% are diagnosed in an advanced stage with 5 years survival rate of only 35%. The aim of this study was to find out the distribution of epidermal growth factor receptor (EGFR) immunoexpression in different histological types and grades of malignant surface epithelial tumours of ovary. A total 54 cases of malignant surface epithelial tumours of ovary from North Okkalapa General and Teaching Hospital and Thingangyun Sanpya General Hospital from August 2015 to September 2016 were included. This study included 30 cases (56%) of serous tumour, 18 cases (33%) mucinous tumour, 5 cases (9%) clear cell tumour and one case (2%) of malignant Brenner tumour. Of the 54 cases, 11 cases (20%) were well differentiated, 33 cases (61%) moderately differentiated and 10 cases (19%) poorly differentiated tumours. Different histological types and grades of malignant surface epithelial ovarian tumours were determined for EGFR immunoexpression by peroxidase antiperoxidase method. Out of 54 cases, 31 cases (57.4%) were found to be positive for EGFR immunoexpression and 23 cases (42.6%) showed negative immunoexpression. Among 31 positive cases of EGFR, 54.8% were serous, 32.3% mucinous, 9.7% clear cell and 3.2% were malignant Brenner tumour. The highest EGFR immunoexpression was found in malignant serous, tumour (54.8%). Regarding the histological grades of the 31 positive cases, EGFR immunoexpression was found 9.7% in well differentiated, 64.5% moderately differentiated and 25.8% in poorly differentiated tumours. Increased EGFR immunoexpression was observed predominantly in higher histological grades of ovarian cancers. Since, high EGFR levels have a negative prognostic role in ovarian cancers, further studies with long-term follow-ups are required to determine the prognosis and management of patients with malignant surface epithelial ovarian tumours.

scholarly journals Non-Epithelial Ovarian Cancer, an Experience From Qatar

2020 ◽  
Author(s):  
Ammar Madani ◽  
Nabil Omar ◽  
Hafedh Ghazouani ◽  
Cicy Jacob ◽  
Aladdin Kanbour ◽  
...  
Keyword(s):  
Early Stage ◽  
Good Prognosis ◽  
Stage I ◽  
P Value ◽  
Ovarian Cancers ◽  
Fertility Sparing ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
Yolk Sac Tumour

Abstract Background: Nonepithelial Ovarian cancers constitute about 10 % of all ovarian cancers. They are divided into Sex-cord stromal tumours (SCST) and Germ cell tumours (GCT). The Aim is to report the experience at National Centre for Cancer Care and Research (NCCCR) in Qatar. Method: This is a retrospective study reviewing records of all patients over 7 years who presented with a histopathologically diagnosed ovarian SCST and GCT at NCCCR between January 2010 and December 2016. Results: 25 women with Non-Epithelial Ovarian Tumours were identified. 13 women were diagnosed with Ovarian SCST. Median age at presentation was 43 years (Range 16-58). 12 patients had stage I and one patient had Stage III. Four patients had recurrence. The 5 years Overall Survival (OS) was 100% and the 5 years Event Free Survival (EFS) was 69% with P value of 0.02. GCT was diagnosed in 12 women. The median age at presentation was 24 years. (Range 16 – 44). Seven patients (59 %) had teratoma, four patients (33 %) had Dysgerminoma and one patient had Yolk sac tumour (8 %). There was one recurrence. 5 years OS was 100 % and 5 years EFS was 83 % with P value of 0.14. Conclusions: Non-Epithelial ovarian tumours are diagnosed relatively at an early stage and have very good prognosis even if they recur. Survival in our study was excellent with all patients alive and disease free at last follow up. For ovarian SCST, we recommend Complete Surgery (TAH + BSO) particularly if high grade, Stage IC and above or completed childbearing to minimize recurrence. Fertility sparing surgery is appropriate for all patients with Stage I Ovarian GCT and most of the patients with Stage II disease who desire fertility preservation.

scholarly journals The BRCA1 c.4096+3A>G Variant Displays Classical Characteristics of Pathogenic BRCA1 Mutations in Hereditary Breast and Ovarian Cancers, But Still Allows Homozygous Viability

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 882 ◽  
Author(s):  
Arason ◽  
Agnarsson ◽  
Johannesdottir ◽  
Johannsson ◽  
Hilmarsdottir ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Brca1 Mutation ◽  
Healthy Woman ◽  
Conclusive Evidence ◽  
Clinical Genetic ◽  
Ovarian Cancers ◽  
Ovarian Tumours ◽  
Heterozygous Carriers ◽  
Exon 11

Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts lacking most or all of exon 11. Nonetheless, homozygosity of this variant has been reported in a healthy woman. We saw this variant cosegregate with breast and ovarian cancer in several family branches of four Icelandic pedigrees, with instances of phenocopies and a homozygous woman with lung cancer. We found eight heterozygous carriers (0.44%) in 1820 unselected breast cancer cases, and three (0.15%) in 1968 controls (p = 0.13). Seeking conclusive evidence, we studied tumors from carriers in the pedigrees for wild-type-loss of heterozygosity (wtLOH) and BRCA1-characteristic prevalence of estrogen receptor (ER) negativity. Of 15 breast and six ovarian tumors, wtLOH occurred in nine breast and all six ovarian tumours, and six of the nine breast tumors with wtLOH were ER-negative. These data accord with a pathogenic BRCA1-mutation. Our findings add to the current knowledge of BRCA1, and the role of its exon 11 in cancer pathogenicity, and will be of use in clinical genetic counselling.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Prognostic significance of tumor apoptosis, p53 and bcl-2 expression in patients with advanced epithelial ovarian cancers

1998 ◽  
Vol 5 (1) ◽  
pp. 82A-82A
Author(s):  
A MUNKARAH ◽  
L BAZZETT ◽  
F QURESHI ◽  
S JACQUES ◽  
R MORRIS ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Ovarian Cancers

Evaluation of concomitant gynecological pathology in group of patients of reproductive age with tumors and tumor formations

2020 ◽  
pp. 10-14
Author(s):  
N. V. Spiridonova ◽  
A. A. Demura ◽  
V. Yu. Schukin
Keyword(s):  
Diagnostic Errors ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Predisposing Factor ◽  
Ovarian Tumours ◽  
Preoperative Diagnostic ◽  
Neoplastic Process ◽  
History Of ◽  
The Moment

According to modern literature, the frequency of preoperative diagnostic errors for tumour-like formations is 30.9–45.6%, for malignant ovarian tumors is 25.0–51.0%. The complexity of this situation is asymptomatic tumor in the ovaries and failure to identify a neoplastic process, which is especially important for young women, as well as ease the transition of tumors from one category to another (evolution of the tumor) and the source of the aggressive behavior of the tumor. The purpose of our study was to evaluate the history of concomitant gynecological pathology in a group of patients of reproductive age with ovarian tumors and tumoroid formations, as a predisposing factor for the development of neoplastic process in the ovaries. In our work, we collected and processed complaints and data of obstetric and gynecological anamnesis of 168 patients of reproductive age (18–40 years), operated on the basis of the Department of oncogynecology for tumors and ovarian tumours in the Samara Regional Clinical Oncology Dispensary from 2012 to 2015. We can conclude that since the prognosis of neoplastic process in the ovaries is generally good with timely detection and this disease occurs mainly in women of reproductive age, doctors need to know that when assessing the parity and the presence of gynecological pathology at the moment or in anamnesis, it is not possible to identify alarming risk factors for the development of cancer in the ovaries.

STEROID STUDIES IN TWO SUBJECTS WITH ANDROGEN-PRODUCING OVARIAN TUMOURS

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S222
Author(s):  
R. Vihko ◽  
T. Laatikainen ◽  
R. Pelkonen
Keyword(s):  
Ovarian Tumours

STUDIES ON THE GROWTH OF EXPERIMENTAL OVARIAN TUMOURS IN TISSUE CULTURE

1959 ◽  
Vol XXXII (I) ◽  
pp. 41-53 ◽  
Author(s):  
Stig Kullander ◽  
Bengt Källén
Keyword(s):  
Tissue Culture ◽  
Granulosa Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Ovarian Tumours

ABSTRACT An in vitro study has been made of experimentally produced rat ovarian tumours of different age, paying particular attention to tumour reaction to crystallized steroids. Tumours of two histological structures were found: granulosa cell – luteoma tumours and arrhenoblastoma tumours. Both types grew in vitro and pictures of their cell appearance are given. The former type gave the best growth, and the endocrine studies were restricted to this type. The steroids tested (androsterone, oestrone, progesterone) all had an arresting effect in certain cases. This effect is not an unspecific, toxic one. The different tumours react to different extents, some being completely unaffected.

Sign in / Sign up

Export Citation Format

Share Document