Eosinophils participate in modulation of liver immune response and tissue damage induced by Schistosoma mansoni infection in mice

Cytokine ◽  
2022 ◽  
Vol 149 ◽  
pp. 155701
Author(s):  
Vinícius Gustavo de Oliveira ◽  
Vanessa Fernandes Rodrigues ◽  
João Marcelo Peixoto Moreira ◽  
Jailza Lima Rodrigues ◽  
Laura Maggi ◽  
...  
Keyword(s):  
Immune Response ◽  
Schistosoma Mansoni ◽  
Tissue Damage

scholarly journals Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection

2004 ◽  
Vol 46 (4) ◽  
pp. 231-233 ◽  
Author(s):  
Fabio Ribeiro ◽  
Rômulo Teixeira de Mello ◽  
Carlos Alberto Pereira Tavares ◽  
John Robert Kusel ◽  
Paulo Marcos Zech Coelho
Keyword(s):  
Immune Response ◽  
Schistosoma Mansoni ◽  
Worm Burden ◽  
Synergistic Action ◽  
Specific Immune Response ◽  
Concomitant Immunity

The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.

scholarly journals Mitochondrial UPR negatively regulates wounding-induced innate immune response in C. elegans epidermis

2021 ◽  
Author(s):  
Jianzhi Zhao ◽  
Hongying Fu ◽  
Hengda Zhou ◽  
Xuecong Ren ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Signaling Pathways ◽  
Innate Immune Response ◽  
Tissue Damage ◽  
P38 Map Kinase ◽  
Innate Immune ◽  
Loss Of Function ◽  
C Elegans ◽  
Unfolded Protein ◽  
Protein Response

Tissue damage elicits a rapid innate immune response that is essential for efficient wound healing and survival of metazoans. It is well known that p38 MAPK kinase, TGF-β, and hemidesmosome signaling pathways have been involved in wounding-induced innate immunity in C. elegans. Here, we find that loss of function of ATFS-1 increased innate immune response while an elevated level of mitochondrial unfolded protein response (mitoUPR) inhibits the innate immune response upon epidermal wounding. Epidermal wounding triggers the nucleus export of ATFS-1 and inhibits themitoUPR in C. elegans epidermis. Moreover, genetic analysis suggests that ATFS-1 functions upstream of the p38 MAP kinase, TGF-β, and DAF-16 signaling pathways in regulating AMPs induction. Thus, our results suggest that the mitoUPR function as an intracellular signal required to fine-tune innate immune response after tissue damage.

scholarly journals Involvement of the Cytokine MIF in the Snail Host Immune Response to the Parasite Schistosoma mansoni

2010 ◽  
Vol 6 (9) ◽  
pp. e1001115 ◽  
Author(s):  
Alvaro Baeza Garcia ◽  
Raymond J. Pierce ◽  
Benjamin Gourbal ◽  
Elisabeth Werkmeister ◽  
Dominique Colinet ◽  
...  
Keyword(s):  
Immune Response ◽  
Schistosoma Mansoni ◽  
Host Immune Response ◽  
Snail Host

A proteomics evaluation of the primary and secondary immune response of Biomphalaria straminea challenged by Schistosoma mansoni

2021 ◽  
Author(s):  
Nairomberg Cavalcanti Portela Junior ◽  
Elverson Soares de Melo ◽  
Iasmim Lopes de Lima ◽  
Rubens Emanoel Tavares da Rocha ◽  
Michel Batista ◽  
...  
Keyword(s):  
Immune Response ◽  
Schistosoma Mansoni ◽  
Secondary Immune Response ◽  
Biomphalaria Straminea

Autoimmunity

2010 ◽  
pp. 267-279
Author(s):  
Antony Rosen
Keyword(s):  
Immune Response ◽  
Autoimmune Diseases ◽  
Tissue Damage ◽  
Adaptive Immune Response ◽  
Peak Incidence ◽  
Adaptive Immune ◽  
The Third

Autoimmune diseases occur when a sustained, specific, adaptive immune response is generated against self-components, and results in tissue damage or dysfunction. They probably affect more than 3% of Western populations, more commonly women than men, and have peak incidence in the third to sixth decades....

Autoimmunity

2020 ◽  
pp. 379-391
Author(s):  
Antony Rosen
Keyword(s):  
Immune Response ◽  
Autoimmune Diseases ◽  
Conceptual Framework ◽  
Economic Burden ◽  
Tissue Damage ◽  
Adaptive Immune Response ◽  
Peak Incidence ◽  
Adaptive Immune ◽  
The Third ◽  
Made In

Autoimmune diseases occur when a sustained, specific, adaptive immune response is generated against self-components, and results in tissue damage or dysfunction. It is now clear that an autoimmune component is a feature of many human diseases. Indeed, there are some estimates that autoimmune diseases afflict more than 3% of Western populations, and imposes a significant personal and economic burden on individuals and nations. They probably affect more commonly women than men, and have peak incidence in the third to sixth decades. This chapter will illustrate many of the principles unifying various autoimmune states, and will present a conceptual framework within which to understand their aetiology, pathogenesis, and pathology. The rapid advances in knowledge being made in this group of disorders predict that disease mechanisms will soon be more clearly understood, and will greatly impact therapeutics.

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