Scarring Alopecia

Introduction: Many procedures are performed on the scalp, such as excision of pilar and sebaceous cysts, melanocytic nevi, and reduction surgery for scarring alopecia, among others. In hair transplants, telogen effluvium is often reported 3 months after surgery; however, hair loss usually happens much earlier, around second week after the procedure, not compatible with the time required for hair to enter telogen and exogenous phases in normal conditions. Case Reports: We report 3 cases of anagen hair loss 4 weeks after surgeries, with perilesional trichoscopy suggesting anagen effluvium, with typical signs such as black dots and exclamation hairs. Discussion: There are only a few reports about hair loss around operated areas. The cause of this postoperative anagen effluvium is probably a transient ischemia. Conclusion: The practical importance of this phenomenon is to properly orient patients because most of the hair will be lost, since 85% of them are anagens, and also will have spontaneous recovery in the next 3 months.

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Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

International Journal of Molecular Sciences ◽

10.3390/ijms21218390 ◽

2020 ◽

Vol 21 (21) ◽

pp. 8390

Author(s):

Antonio Martinez-Lopez ◽

Trinidad Montero-Vilchez ◽

Álvaro Sierra-Sánchez ◽

Alejandro Molina-Leyva ◽

Salvador Arias-Santiago

Keyword(s):

Tissue Engineering ◽

Clinical Trials ◽

Alopecia Areata ◽

Human Tissue ◽

Basic Research ◽

Androgenic Alopecia ◽

Medical Products ◽

Scarring Alopecia ◽

Medical Therapies ◽

Surgical Treatments

Alopecia is a challenging condition for both physicians and patients. Several topical, intralesional, oral, and surgical treatments have been developed in recent decades, but some of those therapies only provide partial improvement. Advanced medical therapies are medical products based on genes, cells, and/or tissue engineering products that have properties in regenerating, repairing, or replacing human tissue. In recent years, numerous applications have been described for advanced medical therapies. With this background, those therapies may have a role in the treatment of various types of alopecia such as alopecia areata and androgenic alopecia. The aim of this review is to provide dermatologists an overview of the different advanced medical therapies that have been applied in the treatment of alopecia, by reviewing clinical and basic research studies as well as ongoing clinical trials.

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Graham-Little Piccardi Lassueur Syndrome: case report

Anais Brasileiros de Dermatologia ◽

10.1590/s0365-05962012000500019 ◽

2012 ◽

Vol 87 (5) ◽

pp. 775-777 ◽

Cited By ~ 6

Author(s):

Raquel Bissacotti Steglich ◽

Renata Elise Tonoli ◽

Giselle Martins Pinto ◽

Fernanda Melo Müller ◽

Isabelle Maffei Guarenti ◽

...

Keyword(s):

Case Report ◽

Physical Examination ◽

Hair Follicles ◽

Rare Disorder ◽

Rare Syndrome ◽

Scarring Alopecia ◽

History Of

A 33-year-old woman presented with a 3-year history of progressive alopecia of the scalp. Past treatment with hydroxicloroquine did not show improvement. Physical examination revealed multiple areas of alopecia with atrophic aspect of the scalp, and axillary and pubic hypotrichosis. Dermoscopy showed hyperkeratosis and accentuation of follicular ostia. Anatomopathological examination revealed decrease in the number of hair follicles, upper perifollicular infiltrate and areas with fibrosis. The Piccardi-Lassueur-Graham-Little syndrome is a rare disorder, characterized by the triad of multifocal scarring alopecia of the scalp, keratotic follicular eruption and hypotrichosis of axillary and pubic regions. Management is a challenge and many medications tried have controversial results. We report a case of this rare syndrome which improved with corticoids.

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Discoid lupus erythematosus skin lesion distribution and characteristics in Black patients: a retrospective cohort study

Lupus Science & Medicine ◽

10.1136/lupus-2021-000514 ◽

2021 ◽

Vol 8 (1) ◽

pp. e000514

Author(s):

Adrienne K Joseph ◽

Brandon Windsor ◽

Linda S Hynan ◽

Benjamin F Chong

Keyword(s):

Cohort Study ◽

Lupus Erythematosus ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Univariate Analysis ◽

Cutaneous Lupus Erythematosus ◽

Discoid Lupus Erythematosus ◽

Anatomical Location ◽

Scarring Alopecia ◽

Black Patients

ObjectiveEpidemiological studies have shown that discoid lupus erythematosus (DLE) has a higher incidence and prevalence in racial/ethnic minority groups, particularly Black individuals. The objective of this retrospective cohort study was to identify the differences in DLE lesion distribution and characteristics in Black individuals compared with non-Black individuals.Methods183 patients with DLE (112 Black patients and 71 non-Black patients) with a reported race/ethnicity and Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) scores were included in this retrospective cohort study. Univariate analysis was performed to determine significant differences in demographic data, clinical characteristics, DLE lesion distribution and DLE lesion characteristics in Black and non-Black patients with DLE. Multivariable logistic regression was preformed to determine significant predictors of DLE lesion location and characteristics.ResultsBlack patients with DLE had worse baseline CLASI damage scores compared with non-Black patients with DLE (median (IQR): 10.0 (6.0–14.5) vs 6.0 (3.0–10.0), p<0.001) and had 48.9 greater odds of dyspigmentation in any anatomical location (p<0.001). Black patients had 2.54 greater odds of having scalp involvement (p=0.015) and 1.97 greater odds of having ear involvement (p=0.032) compared with non-Black patients. Black patients also had greater odds of scalp dyspigmentation (OR=5.85, p<0.001), ear dyspigmentation (OR=2.89, p=0.001) and scarring alopecia (OR=3.00, p=0.001) compared with non-Black patients.ConclusionsSigns of disease damage, particularly ear dyspigmentation, scalp dyspigmentation and scarring alopecia, can more frequently affect Black patients with DLE. Recognising differences in clinical presentation of DLE among Black patients can assist future efforts with understanding biological, cultural, psychosocial and systemic factors that influence DLE presentation and outcomes in Black patients and may guide clinicians when counselling Black patients.

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