Elective endoscopic variceal ligation is not a risk factor for bacterial infection in patients with liver cirrhosis

AbstractLiver function is a most important prognostic factor in patients with liver cirrhosis. Also, portal hypertension is a fatal complication of liver cirrhosis and variceal treatment is indispensable. However, changes of liver functions after endoscopic variceal treatments are unknown. The aim of this study was to evaluate prognosis and liver functions after endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL). A total of liver cirrhotic 103 patients who underwent prophylactic EIS and EVL were enrolled. Overall survival rate was higher in EIS group than EVL group (p = 0.03). Multivariate analysis showed that EIS was a negative factor for death (HR: 0.46, 95% confidence interval: 0.24–0.88, p = 0.02). Liver functions were assessed by blood test taken at before and 3 months after treatment. In EIS group, albumin and prothrombin time improved (p < 0.01), leading to improvement of Child–Pugh score, ALBI score and MELD score (p < 0.05). However, these did not improve in EVL group. EIS was a significant factor related to the elevated value of albumin after treatment in linear regression analysis (estimated regression coefficient: 0.17, 95% confidence interval: 0.05–0.29, p = 0.005). These results revealed that EIS could improve liver functions and prognosis.

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Hepatocellular carcinoma in the non-cirrhotic liver

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211309 ◽

2021 ◽

pp. 1-14

Author(s):

Dong Yi ◽

Wang Wen-Ping ◽

Won Jae Lee ◽

Maria Franca Meloni ◽

Dirk-Andre Clevert ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Cirrhosis ◽

Risk Factor ◽

High Risk ◽

Current Knowledge ◽

Cirrhotic Liver ◽

Imaging Features ◽

Advanced Stage ◽

High Risk Factor ◽

Cirrhotic Patients

Liver cirrhosis is an established high-risk factor for HCC and the majority of patients diagnosed with HCC have cirrhosis. However, HCC also arises in non-cirrhotic livers in approximately 20 %of all cases. HCC in non-cirrhotic patients is often clinically silent and surveillance is usually not recommended. HCC is often diagnosed at an advanced stage in these patients. Current information about HCC in patients with non-cirrhotic liver is limited. Here we review the current knowledge on epidemiology, clinical features and imaging features of those patiens.

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A case of pneumonia and sepsis in cirrhosis as paradigm of the problems in the management of bacterial infections in cirrhosis and of the limitations of current knowledge

Italian Journal of Medicine ◽

10.4081/itjm.2013.209 ◽

2013 ◽

pp. 209-214

Author(s):

Manuel Tufoni ◽

Alessandra Tovoli ◽

Caterina Maggioli ◽

Lucia Napoli ◽

Carmen Serena Ricci ◽

...

Keyword(s):

Liver Cirrhosis ◽

Hepatic Encephalopathy ◽

Hepatitis C ◽

Antibiotic Therapy ◽

Bacterial Infection ◽

Bacterial Infections ◽

Clinical Presentation ◽

Current Knowledge ◽

Empirical Antibiotic Therapy ◽

Increased Risk

Bacterial infections are a major problem in the management of liver cirrhosis. They represent the first precipitating cause of death since patients with cirrhosis carry an increased risk of sepsis, sepsis-induced organ failure and death. Although the clinical presentation is often misleading, the presence of bacterial infection should always be actively searched and ruled out with certainty whenever a cirrhotic patient is admitted to the hospital with an acute clinical deterioration. Major changes in the epidemiology of bacterial infections have also occurred in the last decade making the choice of empirical antibiotic therapy a challenge. We report a paradigmatic case of a 54-year old man with hepatitis C-related cirrhosis admitted to the hospital for worsening of his ascites and onset of hepatic encephalopathy, an excellent example for the difficulties of management of sepsis in cirrhosis and the limits of current knowledge.

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Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis

Human Molecular Genetics ◽

10.1093/hmg/ddu076 ◽

2014 ◽

Vol 23 (14) ◽

pp. 3883-3890 ◽

Cited By ~ 29

Author(s):

F. Stickel ◽

S. Buch ◽

H. Zoller ◽

R. Hultcrantz ◽

S. Gallati ◽

...

Keyword(s):

Liver Cirrhosis ◽

Risk Factor ◽

Iron Metabolism ◽

Hereditary Hemochromatosis ◽

Genome Wide

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Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2017.07.026 ◽

2017 ◽

Vol 63 ◽

pp. 23-29 ◽

Cited By ~ 15

Author(s):

Antonio Riccardo Buonomo ◽

Emanuela Zappulo ◽

Riccardo Scotto ◽

Biagio Pinchera ◽

Giuseppe Perruolo ◽

...

Keyword(s):

Vitamin D ◽

Liver Cirrhosis ◽

Risk Factor ◽

Vitamin D Deficiency

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Is alcohol a risk factor for liver cirrhosis in HBsAg and anti-HCV negative subjects?

Journal of Hepatology ◽

10.1016/s0168-8278(97)80350-9 ◽

1997 ◽

Vol 27 (3) ◽

pp. 470-476 ◽

Cited By ~ 16

Author(s):

Giovanni Corrao ◽

Sarino Aricò ◽

Antonella Zambon ◽

Pierfederico Torchio ◽

Anna Raffaella Lepore ◽

...

Keyword(s):

Liver Cirrhosis ◽

Risk Factor

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Arrhythmia Risk in Patients with ChronicHepatic Disease

Revista de Chimie ◽

10.37358/rc.18.11.6743 ◽

2018 ◽

Vol 69 (11) ◽

pp. 3337-3340 ◽

Cited By ~ 1

Author(s):

Veronica Calborean ◽

Victor Gheorman ◽

Sorin Nicolae Dinescu ◽

Diana Stanca ◽

Oana Galceava ◽

...

Keyword(s):

Atrial Fibrillation ◽

Liver Cirrhosis ◽

Risk Factor ◽

Causes Of Death ◽

Hepatic Disease ◽

Cardiac Symptoms ◽

Ventricular Extrasystoles ◽

The World ◽

Chronic Hepatic Disease ◽

Somatic Status

Cardiac affectation is one of the leading causes of death in the world. Rhythmic disorders such as ventricular extrasystoles, atrial extrasysoles, atrial fibrillation, atrial flutter represent a major risk factor with a gloomy progression and prognosis. Our goal was to analyze the existing arrhythmia risk in patients with chronic hepatic disease. Being known the alteration of the somatic status of the patient with liver cirrhosis or other chronic liver disease in the presence of comorbid cardiac symptoms, we consider vital to prevent arrhythmia risk in hepatic pathology.

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