FAPI PET/CT research progress in digestive system tumours

2021 ◽  
Author(s):  
Dengsai Peng ◽  
Jing He ◽  
Hanxiang Liu ◽  
Jianpeng Cao ◽  
Yingwei Wang ◽  
...  
Keyword(s):  
Digestive System ◽  
Research Progress ◽  
Pet Ct

A Review of the Bioactive Ingredients, Pharmacological Functions and Mechanisms of Inonotus obliquus

2020 ◽  
Vol 17 ◽  
Author(s):  
Gulinigaer Anwaier ◽  
Cong Wen ◽  
Yi-ni Caoili ◽  
Rong Qi
Keyword(s):  
Digestive System ◽  
Treatment Strategies ◽  
Research Progress ◽  
Chemical Components ◽  
Separation And Purification ◽  
Active Components ◽  
Inonotus Obliquus ◽  
Global Issues ◽  
Medicinal Fungus ◽  
Digestive System Diseases

: As a medicinal fungus, Inonotus obliquus (IO) has been widely used in the treatment of cancer and digestive system diseases. Despite the progress that has been made in the studies of IO and its active compounds, their applications in other important clinical diseases, such as cardiovascular diseases, which are major global issues with limited treatment strategies, are seldom reported. This review summarizes the separation and purification methods of chemical components of IO, the advances in their applications, and research progress on the pharmacological effects and related mechanisms of IO in disease prevention. This review will help researchers and clinicians to further understand the pharmacological functions and mechanisms of IO and its active components, which may extend their medical applications in the prevention and treatment of other diseases in addition to tumors and digestive system diseases in the near future.

scholarly journals A Review on the Research Progress of Inducible Nitric Oxide Synthase in the Pathogenesis of Pancreatic Malignancy

2021 ◽  
Vol 5 (4) ◽  
pp. 151-153
Author(s):  
Huimin Xiong ◽  
Ruiyao Wang ◽  
Chao Zhang
Keyword(s):  
Nitric Oxide ◽  
Pancreatic Cancer ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Digestive System ◽  
Malignant Tumors ◽  
Research Progress ◽  
Pancreatic Malignancy ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Pancreatic cancer is a common tumor of the digestive system, at present, the pathogenesis is still unclear, but in the current research on the pathogenesis of pancreatic malignant tumors, the research on inducible nitric oxide synthase is particularly extensive. Therefore, this article focuses on the research progress of inducible nitric oxide synthase in the pathogenesis of pancreatic cancer. This is a review.

Aggressive systemic mastocytosis with diffuse bone marrow 18F-FDG uptake

2021 ◽  
Author(s):  
Renata Koukalová ◽  
Jiří Vašina ◽  
Jiří Štika ◽  
Michael Doubek ◽  
Petr Szturz
Keyword(s):  
Bone Marrow ◽  
Digestive System ◽  
Systemic Mastocytosis ◽  
Primary Tumour ◽  
Bone Marrow Involvement ◽  
Abdominal Ct ◽  
Splenic Parenchyma ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

AbstractMastocytosis is a clonal hematopoietic disorder characterized by proliferation of abnormal mast cells in various organs including the skin, digestive system, lymph nodes, and bone marrow. We report on a 75-year-old woman presenting with abdominal pain, vomiting, diarrhoea, myalgia, and weight loss. Abdominal CT showed hepatosplenomegaly with heterogeneous splenic parenchyma, lymphadenopathy, and osteopenia with areas of osteosclerosis but no primary tumour. An 18F-FDG PET/CT revealed an overall low metabolic activity of the lesions with a diffuse bone marrow involvement raising suspicion of a haematological neoplasm. Subsequently, bone marrow and peripheral blood examinations confirmed the diagnosis of aggressive systemic mastocytosis.

scholarly journals The Regulatory Functions of Circular RNAs in Digestive System Cancers

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 770 ◽  
Author(s):  
Xiao Yuan ◽  
Ya Yuan ◽  
Zhi He ◽  
Diyan Li ◽  
Bo Zeng ◽  
...  
Keyword(s):  
Digestive System ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Circular Rna ◽  
Research Progress ◽  
Circular Rnas ◽  
Biological Functions ◽  
Ribonucleic Acids ◽  
Mirna Sponges ◽  
And Biological Markers

Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer.

scholarly journals FAPI PET/CT in the Diagnosis of Abdominal and Pelvic Tumors

2022 ◽  
Vol 11 ◽  
Author(s):  
Tianshuo Yang ◽  
Long Ma ◽  
Haodong Hou ◽  
Feng Gao ◽  
Weijing Tao
Keyword(s):  
Fdg Pet ◽  
Tumor Staging ◽  
Fibroblast Activation Protein ◽  
Research Progress ◽  
Gastric Mucus ◽  
Primary Tumors ◽  
Fibroblast Activation ◽  
Pelvic Tumors ◽  
Pet Ct ◽  
Fdg Pet Ct

Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) is currently a standard imaging examination used in clinical practice, and plays an essential role in preoperative systemic evaluation and tumor staging in patients with tumors. However, 18F-FDG PET/CT has certain limitations in imaging of some tumors, like gastric mucus adenocarcinoma, highly differentiated hepatocellular carcinoma, renal cell carcinoma, and peritoneal metastasis. Therefore, to search for new tumor diagnosis methods has always been an important topic in radiographic imaging research. Fibroblast activation protein (FAP) is highly expressed in many epithelial carcinomas, and various isotope-labelled fibroblast activation protein inhibitors (FAPI) show lower uptake in the brain and abdominal tissues than in tumor, thus achieving high image contrast and good tumor delineation. In addition to primary tumors, FAPI PET/CT is better than FDG PET/CT for detecting lymph nodes and metastases. Additionally, the highly selective tumor uptake of FAPI may open up new application areas for the non-invasive characterization, staging of tumors, as well as monitoring tumor treatment efficacy. This review focuses on the recent research progress of FAPI PET/CT in the application to abdominal and pelvic tumors, with the aim of providing new insights for diagnostic strategies for tumor patients, especially those with metastases.

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