Relationship betweenGRHL2gene and tumor of the digestive system: research progress

2015 ◽  
Vol 36 (11) ◽  
pp. 1233
Author(s):  
Yi-sha GAO ◽  
Na TA ◽  
Jian-ming ZHENG
Keyword(s):  
Digestive System ◽  
Research Progress ◽  
System Research

A Review of the Bioactive Ingredients, Pharmacological Functions and Mechanisms of Inonotus obliquus

2020 ◽  
Vol 17 ◽  
Author(s):  
Gulinigaer Anwaier ◽  
Cong Wen ◽  
Yi-ni Caoili ◽  
Rong Qi
Keyword(s):  
Digestive System ◽  
Treatment Strategies ◽  
Research Progress ◽  
Chemical Components ◽  
Separation And Purification ◽  
Active Components ◽  
Inonotus Obliquus ◽  
Global Issues ◽  
Medicinal Fungus ◽  
Digestive System Diseases

: As a medicinal fungus, Inonotus obliquus (IO) has been widely used in the treatment of cancer and digestive system diseases. Despite the progress that has been made in the studies of IO and its active compounds, their applications in other important clinical diseases, such as cardiovascular diseases, which are major global issues with limited treatment strategies, are seldom reported. This review summarizes the separation and purification methods of chemical components of IO, the advances in their applications, and research progress on the pharmacological effects and related mechanisms of IO in disease prevention. This review will help researchers and clinicians to further understand the pharmacological functions and mechanisms of IO and its active components, which may extend their medical applications in the prevention and treatment of other diseases in addition to tumors and digestive system diseases in the near future.

FAPI PET/CT research progress in digestive system tumours

2021 ◽  
Author(s):  
Dengsai Peng ◽  
Jing He ◽  
Hanxiang Liu ◽  
Jianpeng Cao ◽  
Yingwei Wang ◽  
...  
Keyword(s):  
Digestive System ◽  
Research Progress ◽  
Pet Ct

scholarly journals A Review on the Research Progress of Inducible Nitric Oxide Synthase in the Pathogenesis of Pancreatic Malignancy

2021 ◽  
Vol 5 (4) ◽  
pp. 151-153
Author(s):  
Huimin Xiong ◽  
Ruiyao Wang ◽  
Chao Zhang
Keyword(s):  
Nitric Oxide ◽  
Pancreatic Cancer ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Digestive System ◽  
Malignant Tumors ◽  
Research Progress ◽  
Pancreatic Malignancy ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Pancreatic cancer is a common tumor of the digestive system, at present, the pathogenesis is still unclear, but in the current research on the pathogenesis of pancreatic malignant tumors, the research on inducible nitric oxide synthase is particularly extensive. Therefore, this article focuses on the research progress of inducible nitric oxide synthase in the pathogenesis of pancreatic cancer. This is a review.

scholarly journals The Regulatory Functions of Circular RNAs in Digestive System Cancers

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 770 ◽  
Author(s):  
Xiao Yuan ◽  
Ya Yuan ◽  
Zhi He ◽  
Diyan Li ◽  
Bo Zeng ◽  
...  
Keyword(s):  
Digestive System ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Circular Rna ◽  
Research Progress ◽  
Circular Rnas ◽  
Biological Functions ◽  
Ribonucleic Acids ◽  
Mirna Sponges ◽  
And Biological Markers

Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer.

Difficulties in assessing alexithymia in motor and non-motor functional gastrointestinal disorders

2011 ◽  
Vol 26 (S2) ◽  
pp. 394-394
Author(s):  
A. Rodríguez-Urrutia ◽  
M.D. Braquehais ◽  
A. Accarino ◽  
M.J. Bel ◽  
M. Quesada ◽  
...  
Keyword(s):  
Psychosocial Factors ◽  
Digestive System ◽  
Functional Gastrointestinal Disorders ◽  
Research Unit ◽  
Gastrointestinal Disorders ◽  
System Research ◽  
Toronto Alexithymia Scale ◽  
The Mean ◽  
Diagnostic Condition ◽  
Tas 20

IntroductionAlexithymia is said to be an important feature of functional gastrointestinal disorders (FGD). Most studies focus on the presence of alexithymia in patients suffering non-motor FGD (NMFGD) but few studies have analyzed its occurrence in motor FGD (MFGD) patients.Objectives- To describe the presence of alexithymia, measured with the Toronto Alexithymia Scale (TAS-20), in a sample of FGD inpatients.- To analyze the differences in alexithymia, measured with the TAS-20, between MFGD and NMFGD inpatients.Material and method46 inpatients admitted to the Vall d’Hebron Digestive System Research Unit to study the existence of FGD were evaluated from January 2008 to July 2010. All patients completed the Toronto Alexithymia Scale (TAS-20).ResultsThe mean age of the sample was 41.02 ± 16.86 years, 89.1% were women and 10.9% were men. With regard to their diagnostic condition, 31 met criteria of NMFGD, 13 of MFGD, and 2 did not met criteria of both disorders. The mean TAS-20 total score was: 46.24 ± 13.60. MFGD patients obtained a mean score of 45.45 ± 12.53, and patients with NMFGD had a mean score of 45.75 ± 12.53. No statistically significant differences were found between both subtypes with regard to alexithymia.ConclusionsAlexithymia, measured with the TAS-20, may not be present in FGD. Discordances of our results with previous findings in FGD may be due to complex psychosocial factors and to psychometric difficulties in assessing alexithymia in this group of patients.

scholarly journals Research Progress on Inducible Nitric Oxide Synthase in the Pathogenesis of Pancreatic Malignancy

2021 ◽  
Vol 5 (4) ◽  
pp. 27-29
Author(s):  
Huimin Xiong ◽  
Ruiyao Wang ◽  
Chao Zhang
Keyword(s):  
Nitric Oxide ◽  
Pancreatic Cancer ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Digestive System ◽  
Malignant Tumors ◽  
Research Progress ◽  
Pancreatic Malignancy ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Pancreatic cancer is a common tumor of the digestive system. At present, the pathogenesis is still unclear, but current research on inducible nitric oxide synthase in relation to the pathogenesis of pancreatic malignant tumors is particularly extensive. Therefore, this article focuses on the research progress on inducible nitric oxide synthase in the pathogenesis of pancreatic cancer.

The Role of PGC-1α in Digestive System Malignant Tumours

2020 ◽  
Vol 20 (3) ◽  
pp. 276-285
Author(s):  
Qiushuang Zhang ◽  
Wei Chen ◽  
Chao Xie ◽  
Xiaoshuo Dai ◽  
Junfen Ma ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Digestive System ◽  
Research Progress ◽  
Malignant Tumours ◽  
Mitochondrial Energy Metabolism ◽  
Pancreatic Cancer Cells ◽  
Incidence And Mortality ◽  
Pancreatic Cancer Stem Cells

Background: Cancer is increasingly becoming the leading cause of death in many countries, and malignant tumours of the digestive system account for majority of cancer incidence and mortality cases. Metabolism has been identified as a core hallmark of cancer. Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α) is a pivotal regulator of mitochondrial energy metabolism. Accumulating evidence reveals that PGC-1α is essential in cancer development. Objective: We summarize the latest research progress of PGC-1α in common digestive system malignant tumours. Some related modulators and pathways are analyzed as well. Methods: We conducted a literature review on the development of PGC-1α in common digestive system malignant tumours. Results: In colorectal cancer, PGC-1α appears to provide growth advantages by different pathways, although it has also been reported to have opposite effects. The previous studies of PGC-1α on liver cancer also demonstrated different effects by sundry pathways. Concerning gastric cancer, PGC-1α promotes cell proliferation, apoptosis in vitro and tumour growth in vivo. AMPK/SIRT1/PGC-1α is related to the inhibition of apoptosis in pancreatic cancer cells. Pancreatic cancer stem cells are strongly dependent on mitochondrial oxidative phosphorylation. PGC-1α is required to maintain the stemness property of pancreatic cancer stem cells. Conclusion: We explore diverse mechanisms that explain the dichotomous functions of PGC-1α on tumorigenesis, and discuss the latest research concerning digestive system malignant tumours. This review would provide better comprehension of the field and a basis for further studies associated with PGC-1α in digestive system cancers.

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