A Review of the Bioactive Ingredients, Pharmacological Functions and Mechanisms of Inonotus obliquus

2020 ◽  
Vol 17 ◽  
Author(s):  
Gulinigaer Anwaier ◽  
Cong Wen ◽  
Yi-ni Caoili ◽  
Rong Qi
Keyword(s):  
Digestive System ◽  
Treatment Strategies ◽  
Research Progress ◽  
Chemical Components ◽  
Separation And Purification ◽  
Active Components ◽  
Inonotus Obliquus ◽  
Global Issues ◽  
Medicinal Fungus ◽  
Digestive System Diseases

: As a medicinal fungus, Inonotus obliquus (IO) has been widely used in the treatment of cancer and digestive system diseases. Despite the progress that has been made in the studies of IO and its active compounds, their applications in other important clinical diseases, such as cardiovascular diseases, which are major global issues with limited treatment strategies, are seldom reported. This review summarizes the separation and purification methods of chemical components of IO, the advances in their applications, and research progress on the pharmacological effects and related mechanisms of IO in disease prevention. This review will help researchers and clinicians to further understand the pharmacological functions and mechanisms of IO and its active components, which may extend their medical applications in the prevention and treatment of other diseases in addition to tumors and digestive system diseases in the near future.

Investigation of Disease Spectrum and Analysis of Risk Factor for Digestive System Diseases of Chinese Army During a Field Training on The Midland of China

2021 ◽  
Author(s):  
Guanjun Zhang ◽  
Mingyang Li ◽  
Fan Lin ◽  
Yizhe Zhang ◽  
Haohui Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Military Service ◽  
Digestive System ◽  
Treatment Strategies ◽  
Training Time ◽  
Field Training ◽  
System Disease ◽  
Disease Spectrum ◽  
Digestive Diseases ◽  
Digestive System Diseases

Abstract Objective To investigate the digestive disease spectrum of Chinese army servicemen during a field training on the midland and to analyze risk factors of diseases in order to discuss the relative prevention and treatment strategies.Methods Seven troops during a field training on the midland of China were randomly selected by using stratified cluster random sampling methods, all soldiers in that received a questionnaire survey, and then we collected all questionnaires and summarized the soldiers’ digestive system disease spectrum, and discussed risk factors for diseases.Results 3055 valid questionnaires were finally collected,896 soldiers had digestive symptoms, and of all symptoms diarrhea was the most common,whose ratio was 29.3%; 507 soldiers suffered from digestive system diseases, including gastritis, enteritis,digestive ulcer, functional bowel disease, which were more common. By the logistic regression analysis, length of military service time, identity of army officer,length of a field training time,training pressure, chilled abdomen, and defiled food were possible risk factors for digestive diseases.Conclusions During a field training, a healthy and regular diet, the thermal outfit, appropriate decompression of negative emotions and reasonable training time may effectively decrease the risk of digestive diseases, so that to reduce attrition.

scholarly journals Gelsemium elegans Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7145
Author(s):  
Hailing Lin ◽  
Hongqiang Qiu ◽  
Yu Cheng ◽  
Maobai Liu ◽  
Maohua Chen ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Research Progress ◽  
Chemical Components ◽  
High Dose ◽  
Pharmacological Effects ◽  
Active Components ◽  
Toxic Dose ◽  
Lead Compounds ◽  
Disease Condition ◽  
Toxicity Mechanisms

Gelsemium elegans Benth (GEB), also known as heartbreak grass, is a highly poisonous plant belonging to the family Loganiaceae and genus Gelsemium that has broad application prospects in medicine. This article reviews its chemical components, pharmacological effects, toxicity mechanisms, and research progress in clinical applications in recent years. Indole alkaloids are the main active components of GEB and have a variety of pharmacological and biological functions. They have anti-tumor, anti-inflammatory, analgesic, and immunomodulation properties, with the therapeutic dose being close to the toxic dose. Application of small-dose indole alkaloids fails to work effectively, while high-dose usage is prone to poisoning, aggravating the patient’s conditions. Special caution is needed, especially to observe the changes in the disease condition of the patients in clinical practice. In-depth research on the chemical components and mechanisms of GEB is essential to the development of promising lead compounds and lays the foundation for extensive clinical application and safe usage of GEB in the future.

Digestive system diseases associated with Turner's syndrome in 3 pediatric cases

2018 ◽  
Author(s):  
Lamia Gargouri ◽  
Faten Hadjkacem ◽  
Dorra Ghorbel ◽  
Faiza Safi ◽  
Manel Hsairi ◽  
...  
Keyword(s):  
Digestive System ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Digestive System Diseases

scholarly journals Mechanism of Compound Houttuynia Mixture as an Anti-COVID-19 Drug Based on Network Pharmacology and Molecular Docking

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110167
Author(s):  
Xing-Pan Wu ◽  
Tian-Shun Wang ◽  
Zi-Xin Yuan ◽  
Yan-Fang Yang ◽  
He-Zhen Wu
Keyword(s):  
Molecular Docking ◽  
Target Prediction ◽  
Interaction Network ◽  
Scientific Basis ◽  
Network Pharmacology ◽  
Chemical Components ◽  
Active Components ◽  
Discovery Studio ◽  
The Core ◽  
Pathway Annotation

Objective To explore the anti-COVID-19 active components and mechanism of Compound Houttuynia mixture by using network pharmacology and molecular docking. Methods First, the main chemical components of Compound Houttuynia mixture were obtained by using the TCMSP database and referring to relevant chemical composition literature. The components were screened for OB ≥30% and DL ≥0.18 as the threshold values. Then Swiss Target Prediction database was used to predict the target of the active components and map the targets of COVID-19 obtained through GeneCards database to obtain the gene pool of the potential target of COVID-19 resistance of the active components of Compound Houttuynia mixture. Next, DAVID database was used for GO enrichment and KEGG pathway annotation of targets function. Cytoscape 3.8.0 software was used to construct a “components-targets-pathways” network. Then String database was used to construct a “protein-protein interaction” network. Finally, the core targets, SARS-COV-2 3 Cl, ACE2 and the core active components of Compound Houttuyna Mixture were imported into the Discovery Studio 2016 Client database for molecular docking verification. Results Eighty-two active compounds, including Xylostosidine, Arctiin, ZINC12153652 and ZINC338038, were screened from Compound Houttuyniae mixture. The key targets involved 128 targets, including MAPK1, MAPK3, MAPK8, MAPK14, TP53, TNF, and IL6. The HIF-1 signaling, VEGF signaling, TNF signaling and another 127 signaling pathways associated with COVID-19 were affected ( P < 0.05). From the results of molecular docking, the binding ability between the selected active components and the core targets was strong. Conclusion Through the combination of network pharmacology and molecular docking technology, this study revealed that the therapeutic effect of Compound Houttuynia mixture on COVID-19 was realized through multiple components, multiple targets and multiple pathways, which provided a certain scientific basis of the clinical application of Compound Houttuynia mixture.

FAPI PET/CT research progress in digestive system tumours

2021 ◽  
Author(s):  
Dengsai Peng ◽  
Jing He ◽  
Hanxiang Liu ◽  
Jianpeng Cao ◽  
Yingwei Wang ◽  
...  
Keyword(s):  
Digestive System ◽  
Research Progress ◽  
Pet Ct

Structure Identification and Evaluation of Chemical Components from the Flos Sophorae Immaturus for Inhibitory Effects against HepG2

2021 ◽  
Vol 19 (4) ◽  
pp. 452-457
Author(s):  
Zhaohui Xue ◽  
Weichen Song ◽  
Xin Gao ◽  
Wancong Yu ◽  
Xiaonan Hou ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Scientific Basis ◽  
Added Value ◽  
Structure Identification ◽  
Chemical Components ◽  
Active Components ◽  
Sophora Japonica ◽  
Beneficial Effects ◽  
Cell Proliferation Inhibition ◽  
Inhibition Potency

Flos Sophorae Immaturus, dried buds of Sophora japonica, exhibits multiple pharmacologic activities including anti-inflammatory, antiaging, and antiallergy effects as well as adjunct to standard of care cancer therapy. However, active components responsible for beneficial effects in cancer are not known. In this study, Flos Sophorae Immaturus was obtained by ethanol extraction, and eight components were purified, identified, and tested for HepG2 cell proliferation inhibition potency. The compounds identified to be the most effective inhibitors were campherol > isorhamnetin > quercetin. These data provide theoretical and scientific basis for the further development, utilization, and the promotion of added value of Flos Sophorae Immaturus.

Research Progress of Essential Oil as a New Complementary Therapy in the Treatment of Depression

2021 ◽  
Vol 21 ◽  
Author(s):  
Xinli Liang ◽  
Xinli Wang ◽  
Guowei Zhao ◽  
Xiaoying Huang ◽  
Xiqiang Xu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Mental Disease ◽  
Complementary Therapy ◽  
Scientific Basis ◽  
Research Progress ◽  
Chemical Components ◽  
Physical And Mental Health ◽  
Plant Essential Oils ◽  
Treatment Of Depression

: Depression is a mood disorder or affective disorder disease with depression as the main symptom. It has become a kind of mental disease that cannot be ignored in the world that seriously endangers human physical and mental health. Antidepressants commonly used in clinics generally have some defects including slow action, unremarkable effects and large side-effects. Therefore, there has a huge developing space for the research of new and effective therapeutic drugs to supplement or replace traditional drugs. Essential oil has obvious advantages in the treatment of depression and other emotional diseases, its aromatic odor can directly stimulate the olfactory nerves, and the lipophilic small- molecular compounds can cross the blood-brain barrier easily, to play its regulatory role of releasing of neurotransmitters and hormones related to depression, or adjusting the expression of brain-derived neurotrophic factor and proinflammatory cytokines. The pathogenesis of depression and the problems in traditional medication was illustrated, the research on the antidepressant effects and mechanism of essential oils in recent years was summarized and the antidepressant chemical components in plant essential oils were reviewed in this article. It could provide scientific basis for essential oil to be a new choice for relieving depression and treating depression.

scholarly journals Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

2013 ◽  
Vol 16 (4) ◽  
pp. 530 ◽  
Author(s):  
Hitesh B Vaidya ◽  
Abeer A Ahmed ◽  
Ramesh K Goyal ◽  
Sukhinder K Cheema
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Glycogen Phosphorylase ◽  
Docking Studies ◽  
Chemical Components ◽  
Active Components ◽  
Active Chemical ◽  
Treatment Of Diabetes ◽  
Secoiridoid Glycosides ◽  
Common Target

Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess similarities in their active chemical components, e.g. iridoid and secoiridoid glycosides. Methods. In this study, we have compared the structure of various iridoid and secoiridoid glycosides to design a novel pharmacophore. We further developed a structure-activity relationship for the inhibition of glycogen phosphorylase-a. Conclusion. By using docking studies, we are proposing, for the first time, that inhibition of glycogen phosphorylase-a activity is a common target for iridoids and secoiridoids to elicit anti-diabetic effects. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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