scholarly journals Long-term neuropsychological and behavioral outcome of mild and moderate hypoxic ischemic encephalopathy

2022 ◽  
pp. 105541
Author(s):  
Stephen Halpin ◽  
Chris McCusker ◽  
Leanna Fogarty ◽  
Jennie White ◽  
Emilie Cavalière ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Behavioral Outcome ◽  
Ischemic Encephalopathy

Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy

2015 ◽  
Vol 19 (3) ◽  
pp. 354-359 ◽  
Author(s):  
Petra E.M. van Schie ◽  
Josephine Schijns ◽  
Jules G. Becher ◽  
Frederik Barkhof ◽  
Mirjam M. van Weissenbruch ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Behavioral Outcome ◽  
Ischemic Encephalopathy

Long-Term Neuropsychological and Behavioral Outcome of Mild and Moderate Hypoxic Ischemic Encephalopathy

2021 ◽  
Author(s):  
Stephen Halpin ◽  
Christopher G. McCusker ◽  
Leanna Fogarty ◽  
Jennifer E. White ◽  
Emilie Cavaliere ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Behavioral Outcome ◽  
Ischemic Encephalopathy

scholarly journals The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy

2021 ◽  
Vol 22 (9) ◽  
pp. 4822
Author(s):  
Viktória Kovács ◽  
Gábor Remzső ◽  
Tímea Körmöczi ◽  
Róbert Berkecz ◽  
Valéria Tóth-Szűki ◽  
...  
Keyword(s):  
Neuronal Activity ◽  
Kynurenic Acid ◽  
Neuronal Damage ◽  
Brain Regions ◽  
Hypoxic Ischemic Encephalopathy ◽  
Hippocampal Field ◽  
Power Spectral ◽  
Density Values ◽  
Ischemic Encephalopathy

Hypoxic–ischemic encephalopathy (HIE) remains to be a major cause of long-term neurodevelopmental deficits in term neonates. Hypothermia offers partial neuroprotection warranting research for additional therapies. Kynurenic acid (KYNA), an endogenous product of tryptophan metabolism, was previously shown to be beneficial in rat HIE models. We sought to determine if the KYNA analog SZR72 would afford neuroprotection in piglets. After severe asphyxia (pHa = 6.83 ± 0.02, ΔBE = −17.6 ± 1.2 mmol/L, mean ± SEM), anesthetized piglets were assigned to vehicle-treated (VEH), SZR72-treated (SZR72), or hypothermia-treated (HT) groups (n = 6, 6, 6; Tcore = 38.5, 38.5, 33.5 °C, respectively). Compared to VEH, serum KYNA levels were elevated, recovery of EEG was faster, and EEG power spectral density values were higher at 24 h in the SZR72 group. However, instantaneous entropy indicating EEG signal complexity, depression of the visual evoked potential (VEP), and the significant neuronal damage observed in the neocortex, the putamen, and the CA1 hippocampal field were similar in these groups. In the caudate nucleus and the CA3 hippocampal field, neuronal damage was even more severe in the SZR72 group. The HT group showed the best preservation of EEG complexity, VEP, and neuronal integrity in all examined brain regions. In summary, SZR72 appears to enhance neuronal activity after asphyxia but does not ameliorate early neuronal damage in this HIE model.

scholarly journals Long Term Outcome after Therapeutic Hypothermia in Neonatal Hypoxic-ischemic Encephalopathy

2016 ◽  
Vol 24 (4) ◽  
pp. 246-250 ◽  
Author(s):  
김지훈 ◽  
문청준 ◽  
성인경 ◽  
윤영아 ◽  
빈중현 ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Hypoxic Ischemic Encephalopathy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Ischemic Encephalopathy

scholarly journals Neurodevelopmental outcome of babies with hypoxic ischemic encephalopathy

2017 ◽  
Vol 5 (7) ◽  
pp. 3197
Author(s):  
Sirajuddin Nazeer ◽  
Senthilkumar K. ◽  
Thangavel A. ◽  
Uma Maheswari M.
Keyword(s):  
Neurological Outcome ◽  
Neurodevelopmental Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Mri Brain ◽  
Early Markers ◽  
Cdc Grading ◽  
Ischemic Encephalopathy

Background: The aim of the study was to find out the neurodevelopmental outcome of babies with hypoxic ischemic encephalopathy at 6 months of age and to predict early markers of abnormal neurological outcome in those babies.Methods: 50 babies admitted with hypoxic ischemic encephalopathy were enrolled in this prospective study and followed up at 3 and 6 months of age at Mahatma Gandhi Memorial Government Hospital, Trichy. The neurological outcome of the babies was assessed by CDC grading of motor milestones, Trivandrum development screening chart, Amiel Tison angles head circumference and weight measured. USG cranium was done for all the babies and MRI brain was done in babies with abnormal neuro sonogram and abnormal outcome. Vision and hearing were tested clinically.Results: The incidence of abnormal neurological outcome was 14%. The early markers predicting abnormal neurological sequele are identified.Conclusions: Early identification of abnormal neuro behaviour helps in starting early intervention to improve the long term outcome.

scholarly journals Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy

2019 ◽  
Vol 35 (3) ◽  
pp. 477-483 ◽  
Author(s):  
Francesco Cavallin ◽  
Giulia Rubin ◽  
Enrico Vidal ◽  
Elisa Cainelli ◽  
Luca Bonadies ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Prognostic Role ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Ischemic Encephalopathy

scholarly journals Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy

2019 ◽  
Vol 362 ◽  
pp. 77-81 ◽  
Author(s):  
Melinda Barkhuizen ◽  
Ralph van Mechelen ◽  
Marijne Vermeer ◽  
Peter Chedraui ◽  
Dean Paes ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neurodevelopmental Outcomes ◽  
Multipotent Adult Progenitor Cells ◽  
Ischemic Encephalopathy
Sign in / Sign up

Export Citation Format

Share Document