Author's reply - factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff: A systematic review and meta-analysis

Abstract Background Few studies have focused on exploring the clinical characteristics and outcomes of COVID-19 in older patients. We conducted this systematic review and meta-analysis to have a better understanding of the clinical characteristics of older COVID-19 patients. Methods A systematic search of PubMed and Scopus was performed from December 2019 to May 3rd, 2020. Observational studies including older adults (age ≥ 60 years) with COVID-19 infection and reporting clinical characteristics or outcome were included. Primary outcome was assessing weighted pooled prevalence (WPP) of severity and outcomes. Secondary outcomes were clinical features including comorbidities and need of respiratory support. Result Forty-six studies with 13,624 older patients were included. Severe infection was seen in 51% (95% CI– 36-65%, I2–95%) patients while 22% (95% CI– 16-28%, I2–88%) were critically ill. Overall, 11% (95% CI– 5-21%, I2–98%) patients died. The common comorbidities were hypertension (48, 95% CI– 36-60% I2–92%), diabetes mellitus (22, 95% CI– 13-32%, I2–86%) and cardiovascular disease (19, 95% CI – 11-28%, I2–85%). Common symptoms were fever (83, 95% CI– 66-97%, I2–91%), cough (60, 95% CI– 50-70%, I2–71%) and dyspnoea (42, 95% CI– 19-67%, I2–94%). Overall, 84% (95% CI– 60-100%, I2–81%) required oxygen support and 21% (95% CI– 0-49%, I2–91%) required mechanical ventilation. Majority of studies had medium to high risk of bias and overall quality of evidence was low for all outcomes. Conclusion Approximately half of older patients with COVID-19 have severe infection, one in five are critically ill and one in ten die. More high-quality evidence is needed to study outcomes in this vulnerable patient population and factors affecting these outcomes.

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Factors affecting the incidence of postoperative periprosthetic fractures following primary and revision hip arthroplasty: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-020-02152-0 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Christos Bissias ◽

Angelos Kaspiris ◽

Athanasios Kalogeropoulos ◽

Konstantinos Papoutsis ◽

Nikolaos Natsioulas ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Systematic Review ◽

Meta Analysis ◽

Revision Arthroplasty ◽

Female Gender ◽

Periprosthetic Fractures ◽

Factors Affecting ◽

Potential Risk Factors ◽

Grade 3

Abstract Objectives The increasing number of hip arthroplasties (HA), due to the growing elderly population, is associated with the risk of femoral periprosthetic fractures (FPFs). The purpose of this study was to identify potential risk factors for the development of FPFs after HA. Methods A systematic review was conducted in five data bases (Medline, Embase, Cochrane, Cinahl, ICTRP) according to the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) guidelines up to May 2019, using the key words “risk factor,” “periprosthetic fracture,” and “hip replacement or arthroplasty.” Meta-analysis of the clinical outcomes of HA and subgroup analysis based on the factors that were implicated in FPFs was performed. Results Sixteen studies were included (sample size: 599,551 HA patients, 4253 FPFs, incidence 0.71%). Risk factors statistically associated with increased incidence of FPFs were female gender (+ 40%), previous revision arthroplasty surgery (× 3 times), and the presence of rheumatoid arthritis (× 2.1 times), while osteoarthritis (− 57%), cement application (− 59%), and insertion of Biomet (− 68%) or Thompson’s prosthesis (− 75%) were correlated with low prevalence of FPFs. Obesity, cardiac diseases, advanced age, bad general health (ASA grade ≥ 3), and use of Exeter or Lubinus prosthesis were not linked to the appearance of FPFs. Conclusion This meta-analysis suggested that female gender, rheumatoid arthritis, and revision arthroplasty are major risk factors for the development of FPFs after a HA. In those patients, frequent follow-ups should be planned. Further prospective studies are necessary to clarify all the risk factors contributing to the appearance of FPFs after HA.

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Factors affecting usage of crossing structures by wildlife – A systematic review and meta-analysis

The Science of The Total Environment ◽

10.1016/j.scitotenv.2021.146061 ◽

2021 ◽

Vol 777 ◽

pp. 146061

Author(s):

Dror Denneboom ◽

Avi Bar-Massada ◽

Assaf Shwartz

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Factors Affecting ◽

Crossing Structures

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The prevalence of sleep disturbances among physicians and nurses facing the COVID-19 patients: a systematic review and meta-analysis

Globalization and Health ◽

10.1186/s12992-020-00620-0 ◽

2020 ◽

Vol 16 (1) ◽

Author(s):

Nader Salari ◽

Habibolah Khazaie ◽

Amin Hosseinian-Far ◽

Hooman Ghasemi ◽

Masoud Mohammadi ◽

...

Keyword(s):

Systematic Review ◽

Sample Size ◽

Medical Staff ◽

Sleep Disturbances ◽

Meta Analysis ◽

Workplace Stress ◽

Cross Sectional ◽

Significance Level ◽

Nurses And Physicians ◽

As Stress

Abstract Background In all epidemics, healthcare staff are at the centre of risks and damages caused by pathogens. Today, nurses and physicians are faced with unprecedented work pressures in the face of the COVID-19 pandemic, resulting in several psychological disorders such as stress, anxiety and sleep disturbances. The aim of this study is to investigate the prevalence of sleep disturbances in hospital nurses and physicians facing the COVID-19 patients. Method A systematic review and metanalysis was conducted in accordance with the PRISMA criteria. The PubMed, Scopus, Science direct, Web of science, CINHAL, Medline, and Google Scholar databases were searched with no lower time-limt and until 24 June 2020. The heterogeneity of the studies was measured using I2 test and the publication bias was assessed by the Egger’s test at the significance level of 0.05. Results The I2 test was used to evaluate the heterogeneity of the selected studies, based on the results of I2 test, the prevalence of sleep disturbances in nurses and physicians is I2: 97.4% and I2: 97.3% respectively. After following the systematic review processes, 7 cross-sectional studies were selected for meta-analysis. Six studies with the sample size of 3745 nurses were examined in and the prevalence of sleep disturbances was approximated to be 34.8% (95% CI: 24.8-46.4%). The prevalence of sleep disturbances in physicians was also measured in 5 studies with the sample size of 2123 physicians. According to the results, the prevalence of sleep disturbances in physicians caring for the COVID-19 patients was reported to be 41.6% (95% CI: 27.7-57%). Conclusion Healthcare workers, as the front line of the fight against COVID-19, are more vulnerable to the harmful effects of this disease than other groups in society. Increasing workplace stress increases sleep disturbances in the medical staff, especially nurses and physicians. In other words, increased stress due to the exposure to COVID-19 increases the prevalence of sleep disturbances in nurses and physicians. Therefore, it is important for health policymakers to provide solutions and interventions to reduce the workplace stress and pressures on medical staff.

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Positional factors affecting the bond failure rates in orthodontic treatment: A systematic review and meta-analysis

Orthodontic Waves ◽

10.1016/j.odw.2019.06.001 ◽

2019 ◽

Vol 78 (3) ◽

pp. 93-101

Author(s):

Ömer Hatipoğlu ◽

Abdurahman Küçükönder ◽

Ekrem Oral

Keyword(s):

Systematic Review ◽

Orthodontic Treatment ◽

Meta Analysis ◽

Failure Rates ◽

Bond Failure ◽

Factors Affecting

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Preoperative Patient Factors Affecting Length of Stay following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis

The Journal of Arthroplasty ◽

10.1016/j.arth.2019.04.048 ◽

2019 ◽

Vol 34 (9) ◽

pp. 2124-2165.e1 ◽

Cited By ~ 9

Author(s):

Ajay Shah ◽

Muzammil Memon ◽

Jeffrey Kay ◽

Thomas J. Wood ◽

Daniel M. Tushinski ◽

...

Keyword(s):

Systematic Review ◽

Total Knee Arthroplasty ◽

Length Of Stay ◽

Knee Arthroplasty ◽

Meta Analysis ◽

Patient Factors ◽

Factors Affecting ◽

Total Knee ◽

Preoperative Patient

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Low-dose or no aspirin administration in acute-phase Kawasaki disease: a meta-analysis and systematic review

Archives of Disease in Childhood ◽

10.1136/archdischild-2019-318245 ◽

2020 ◽

pp. archdischild-2019-318245

Author(s):

Ming-Hsiu Chiang ◽

Hsingjin Eugene Liu ◽

Jinn-Li Wang

Keyword(s):

Systematic Review ◽

Kawasaki Disease ◽

Acute Phase ◽

Low Dose ◽

Meta Analysis ◽

Length Of Hospital Stay ◽

High Dose ◽

Cochrane Central Register ◽

Factors Affecting ◽

Standard Mean Difference

ObjectiveTo compare the efficacy of low-dose or no aspirin with conventional high-dose aspirin for the initial treatment in the acute-phase of Kawasaki disease (KD).DesignA meta-analysis and systematic review of randomised control trials and cohort studies.MethodsAll available articles that compared different dosage of aspirin in the acute-phase of KD published until 20 September 2019 were included from the databases of PubMed, Embase and Cochrane Central Register of Controlled Trials Central without language restrictions. Extracted data from eligible studies were reviewed by two authors independently and analysed by using RStudio software.ResultsNine cohorts with a total of 12 182 children were enrolled. We found that low-dose (3–5 mg/kg/day) or no aspirin in the acute-phase KD was associated with reducing the risk of coronary artery lesions (CALs, OR=0.81, 95% CI 0.69 to 0.95). No differences were observed in intravenous immunoglobulin resistance, length of hospital stay and fever days after admission (OR=1.35, 95% CI 0.91 to 1.98; standard mean difference (SMD)=0.17, 95% CI −1.07 to 1.4; SMD=0.3, 95% CI −1.51 to 2.11) in the low-dose/no aspirin subgroup compared with the high-dose (≥30 mg/kg/day) aspirin subgroup. We did not identify any potential factors affecting the homogeneity of CAL risk as well as clinical important effects in all included studies.ConclusionsPrescribing low-dose or no aspirin in the acute-phase of KD might be associated with a decreased incidence of CAL. However, additional well-designed prospective trials are required to support the theory.

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