Persistent DNA methylation changes in zebrafish following graphene quantum dots exposure in surface chemistry-dependent manner

In this study, the antibacterial behavior of differing sized graphene quantum dots (GQDs) was studied. The gram negative bacteria, Escherichia coli (E. coli), were used as the bacteria mode. Different sized GQDs with tunable fluorescent colors were acquired by a gel-filtration method. The size, surface chemistry, and photoluminescence properties of GQDs were characterized, respectively. The viability of GQDs treated bacteria was determined by the standard plate counting method. Moreover, the reactive oxidative species (ROS) level was detected by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) method. The integrality of the bacteria membrane was observed under the scanning electron microscopy (SEM). The experimental results indicated that GQDs demonstrated size-dependent and surface chemistry-dependent antibacterial behaviors. This research provided insightful guidelines in the selection of suitable GQDs for their potential bioapplications.

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One-pot synthesis of sulfur-doped graphene quantum dots as a novel fluorescent probe for highly selective and sensitive detection of lead(ii)

RSC Advances ◽

10.1039/c6ra10836a ◽

2016 ◽

Vol 6 (74) ◽

pp. 69977-69983 ◽

Cited By ~ 45

Author(s):

Shiyue Bian ◽

Chao Shen ◽

Hong Hua ◽

Lin Zhou ◽

Hailin Zhu ◽

...

Keyword(s):

Crystal Structure ◽

Quantum Dots ◽

Surface Chemistry ◽

Graphene Quantum Dots ◽

Sensitive Detection ◽

Monolayer Graphene ◽

One Pot ◽

Doped Graphene ◽

One Step ◽

The One

A facile strategy was developed for the one-step synthesis of S-GQDs with a monolayer-graphene crystal structure. The change of surface chemistry by S-doping resulted in selective and sensitive detection of Pb2+.

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Enhanced selectivity of microfluidic gas sensors by modifying microchannel geometry and surface chemistry with graphene quantum dots

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2021.130050 ◽

2021 ◽

pp. 130050

Author(s):

Mahan Ghazi ◽

Sajjad Janfaza ◽

Hamed Tahmooressi ◽

Adithya Ravishankara ◽

Emily Earl ◽

...

Keyword(s):

Quantum Dots ◽

Surface Chemistry ◽

Gas Sensors ◽

Graphene Quantum Dots ◽

Enhanced Selectivity

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A fluorometric study on the effect of DNA methylation on DNA interaction with graphene quantum dots

Methods and Applications in Fluorescence ◽

10.1088/2050-6120/aaff95 ◽

2019 ◽

Vol 7 (2) ◽

pp. 025001 ◽

Cited By ~ 7

Author(s):

Samaneh Rafiei ◽

Mehdi Dadmehr ◽

Morteza Hosseini ◽

Hanie Ahmadzade Kermani ◽

Mohammad Reza Ganjali

Keyword(s):

Dna Methylation ◽

Quantum Dots ◽

Graphene Quantum Dots ◽

Dna Interaction ◽

Fluorometric Study

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Graphene Quantum Dots’ Surface Chemistry Modulates the Sensitivity of Glioblastoma Cells to Chemotherapeutics

International Journal of Molecular Sciences ◽

10.3390/ijms21176301 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6301 ◽

Cited By ~ 2

Author(s):

Giordano Perini ◽

Valentina Palmieri ◽

Gabriele Ciasca ◽

Marcello D’Ascenzo ◽

Jacopo Gervasoni ◽

...

Keyword(s):

Quantum Dots ◽

Surface Chemistry ◽

Cortical Neurons ◽

Therapeutic Strategy ◽

Graphene Quantum Dots ◽

Chemotherapeutic Drugs ◽

Chemotherapeutic Drug ◽

Glioblastoma Cells ◽

Therapy Efficacy ◽

Surface Chemistries

Recent evidence has shown that graphene quantum dots (GQDs) are capable of crossing the blood–brain barrier, the barrier that reduces cancer therapy efficacy. Here, we tested three alternative GQDs’ surface chemistries on two neural lineages (glioblastoma cells and mouse cortical neurons). We showed that surface chemistry modulates GQDs’ biocompatibility. When used in combination with the chemotherapeutic drug doxorubicin, GDQs exerted a synergistic effect on tumor cells, but not on neurons. This appears to be mediated by the modification of membrane permeability induced by the surface of GQDs. Our findings highlight that GQDs can be adopted as a suitable delivery and therapeutic strategy for the treatment of glioblastoma, by both directly destabilizing the cell membrane and indirectly increasing the efficacy of chemotherapeutic drugs.

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Investigating the bioavailability of graphene quantum dots in lung tissues via Fourier transform infrared spectroscopy

Interface Focus ◽

10.1098/rsfs.2017.0054 ◽

2018 ◽

Vol 8 (3) ◽

pp. 20170054 ◽

Cited By ~ 10

Author(s):

Tanveer A. Tabish ◽

Liangxu Lin ◽

Muhammad Ali ◽

Farhat Jabeen ◽

Muhammad Ali ◽

...

Keyword(s):

Quantum Dots ◽

Fourier Transform ◽

Infrared Spectroscopy ◽

Fourier Transform Infrared Spectroscopy ◽

Graphene Quantum Dots ◽

Fourier Transform Infrared ◽

Living Organism ◽

Dependent Manner ◽

Complex Process ◽

High Doses

Biomolecular fractions affect the fate and behaviour of quantum dots (QDs) in living systems but how the interactions between biomolecules and QDs affect the bioavailability of QDs is a major knowledge gap in risk assessment analysis. The transport of QDs after release into a living organism is a complex process. The majority accumulate in the lungs where they can directly affect the inhalation process and lung architecture. Here, we investigate the bioavailability of graphene quantum dots (GQDs) to the lungs of rats by measuring the alterations in macromolecular fractions via Fourier transform infrared spectroscopy (FTIR). GQDs were intravenously injected into the rats in a dose-dependent manner (low (5 mg kg −1 ) and high (15 mg kg −1 ) doses of GQDs per body weight of rat) for 7 days. The lung tissues were isolated, processed and haematoxylin–eosin stained for histological analysis to identify cell death. Key biochemical differences were identified by spectral signatures: pronounced changes in cholesterol were found in two cases of low and high doses; a change in phosphorylation profile of substrate proteins in the tissues was observed in low dose at 24 h. This is the first time biomolecules have been measured in biological tissue using FTIR to investigate the biocompatibility of foreign material. We found that highly accurate toxicological changes can be investigated with FTIR measurements of tissue sections. As a result, FTIR could form the basis of a non-invasive pre-diagnostic tool for predicting the toxicity of GQDs.

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