Smoke and alcohol consumption as a risk factors in the development of second primary neoplasms (SPN) in head & neck cancer (HNC) patients. A case-control study

Abstract Background This study aimed to identify the risk factors and evaluate the prognosis of unplanned reintubation caused by acute airway compromise (AAC) after general anesthesia. Methods This case-control study included surgical patients who underwent unplanned reintubation in the operating room and postanesthesia care unit after general anesthesia between January 1, 2014, and December 31, 2018. Cases due to AAC were matched 1:4 with randomly selected controls. Results A total of 123,068 patients were included, and reintubation due to AAC was performed in 36 patients (approximate incidence 0.03%). Univariable analysis revealed that male sex, age > 65, ASA physical status 3, sepsis, heart disease history, cerebral infarction history, Cormack Lehane grade, surgery type, fresh frozen plasma infusion, increased intubation duration, white blood cell count, and creatinine clearance rate were related to AAC-caused unplanned reintubation. Multivariable analysis revealed that age > 65 (OR = 7.50, 95% CI 2.47–22.81, P < 0.001), ASA physical status 3 (OR = 6.51, 95% CI 1.18–35.92, P = 0.032), head-neck surgery (OR = 4.94, 95% CI 1.33–18.36, P = 0.017) or thoracic surgery (OR = 12.56, 95% CI 2.93–53.90, P < 0.001) and a high fluid load (OR = 3.04, 95% CI 1.16–7.99, P = 0.024) were associated with AAC-caused unplanned reintubation. AAC-caused unplanned reintubation patients had longer postoperative hospital (OR = 5.26, 95% CI 1.57–8.95, P < 0.001) and intensive care unit days (OR = 3.94, 95% CI 1.69–6.18, P < 0.001). Conclusions Age > 65, ASA physical status 3, head-neck or thoracic surgery and high fluid load were found to be associated with AAC-caused unplanned reintubation.

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Risk factors for unplanned reintubation caused by acute airway compromise after general anesthesia: a case-control study

10.21203/rs.3.rs-50532/v3 ◽

2020 ◽

Author(s):

Si Chen ◽

Yuelun Zhang ◽

Lu Che ◽

Le Shen ◽

Yuguang Huang

Keyword(s):

Risk Factors ◽

General Anesthesia ◽

Case Control Study ◽

Case Control ◽

Airway Compromise ◽

Physical Status ◽

Fluid Load ◽

High Fluid ◽

Head Neck ◽

Control Study

Abstract Background: This study aimed to identify the risk factors and evaluate the prognosis of unplanned reintubation caused by acute airway compromise (AAC) after general anesthesia.Methods: This case-control study included surgical patients who underwent unplanned reintubation in the operating room and postanesthesia care unit after general anesthesia between January 1, 2014, and December 31, 2018. Cases due to AAC were matched 1:4 with randomly selected controls.Results: A total of 123,068 patients were included, and reintubation due to AAC was performed in 36 patients (approximate incidence 0.03%). Univariable analysis revealed that male sex, age >65, ASA physical status 3, sepsis, heart disease history, cerebral infarction history, Cormack Lehane grade, surgery type, fresh frozen plasma infusion, increased intubation duration, white blood cell count, and creatinine clearance rate were related to AAC-caused unplanned reintubation. Multivariable analysis revealed that age >65 (OR=7.50, 95% CI 2.47-22.81, P<0.001), ASA physical status 3 (OR=6.51, 95% CI 1.18-35.92, P=0.032), head-neck surgery (OR=4.94, 95% CI 1.33-18.36, P=0.017) or thoracic surgery (OR=12.56, 95% CI 2.93-53.90, P<0.001) and a high fluid load (OR=3.04, 95% CI 1.16-7.99, P=0.024) were associated with AAC-caused unplanned reintubation. AAC-caused unplanned reintubation patients had longer postoperative hospital (OR=5.26, 95% CI 1.57-8.95, P<0.001) and intensive care unit days (OR=3.94, 95% CI 1.69-6.18, P<0.001).Conclusions: Age>65, ASA physical status 3, head-neck or thoracic surgery and high fluid load were found to be associated with AAC-caused unplanned reintubation.

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Tobacco smoking and alcohol consumption as risk factors for thymoma – A European case-control study

Cancer Epidemiology ◽

10.1016/j.canep.2019.06.008 ◽

2019 ◽

Vol 61 ◽

pp. 133-138 ◽

Cited By ~ 3

Author(s):

Mikael Eriksson ◽

Linda Kaerlev ◽

Preben Johansen ◽

Noemia Afonso ◽

Wolfgang Ahrens ◽

...

Keyword(s):

Risk Factors ◽

Alcohol Consumption ◽

Tobacco Smoking ◽

Case Control Study ◽

Case Control ◽

Control Study

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Investigating the Synergistic Interaction of Diabetes, Tobacco Smoking, Alcohol Consumption, and Hypercholesterolemia on the Risk of Pancreatic Cancer: A Case-Control Study in Italy

BioMed Research International ◽

10.1155/2014/481019 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 11

Author(s):

Giuseppe La Torre ◽

Antonella Sferrazza ◽

Maria Rosaria Gualano ◽

Chiara de Waure ◽

Gennaro Clemente ◽

...

Keyword(s):

Risk Factors ◽

Pancreatic Cancer ◽

Alcohol Consumption ◽

Case Control Study ◽

Smoking Status ◽

Conditional Logistic Regression ◽

Case Control ◽

Synergistic Interaction ◽

Independent Risk Factors ◽

Control Study

The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors. A case-control study (80 patients and 392 controls) was conducted at the Teaching Hospital “Agostino Gemelli” in Rome. A conditional logistic regression was used for the statistical analysis and results were presented as odds ratio (OR) and 95% confidence intervals (95% CI). We also investigated the possible interactions between risk factors and calculated the synergism index (SI). The multivariate analysis revealed that hypercholesterolemia and alcohol consumption resulted in important risk factors for pancreatic cancer even after the adjustment for all variables (OR: 5.05, 95% CI: 2.94–8.66; OR: 2.25, 95% CI: 1.30–3.89, resp.). Interestingly, important synergistic interactions between risk factors were found, especially between ever smoking status and alcohol consumptions (SI = 17.61) as well as alcohol consumption and diabetes (SI = 17.77). In conclusion, the study confirms that hypercholesterolemia and alcohol consumption represent significant and independent risk factors for pancreatic cancer. Moreover, there is evidence of synergistic interaction between diabetes and lifestyle factors (drinking alcohol and eating fatty foods).

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Tobacco smoking and alcohol consumption as risk factors for glioma: a case-control study in Melbourne, Australia.

Journal of Epidemiology & Community Health ◽

10.1136/jech.50.4.442 ◽

1996 ◽

Vol 50 (4) ◽

pp. 442-446 ◽

Cited By ~ 27

Author(s):

S F Hurley ◽

J J McNeil ◽

G A Donnan ◽

A Forbes ◽

M Salzberg ◽

...

Keyword(s):

Risk Factors ◽

Alcohol Consumption ◽

Tobacco Smoking ◽

Case Control Study ◽

Case Control ◽

Control Study

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Alcohol Consumption and Micronutrient Intake as Risk Factors for Liver Cirrhosis: A Case-Control Study

Annals of Epidemiology ◽

10.1016/s1047-2797(97)00193-2 ◽

1998 ◽

Vol 8 (3) ◽

pp. 154-159 ◽

Cited By ~ 23

Author(s):

Giovanni Corrao ◽

Pierfederico Torchio ◽

Antonella Zambon ◽

Amleto D'Amicis ◽

Anna Raffaella Lepore ◽

...

Keyword(s):

Risk Factors ◽

Liver Cirrhosis ◽

Alcohol Consumption ◽

Case Control Study ◽

Case Control ◽

Micronutrient Intake ◽

Control Study

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Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren’s Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study

Journal of Immunology Research ◽

10.1155/2019/9060842 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Hadas Ben-Eli ◽

Doron J. Aframian ◽

Eldad Ben-Chetrit ◽

Dror Mevorach ◽

Geffen Kleinstern ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Alcohol Consumption ◽

B Cell ◽

Dry Eye ◽

Case Control Study ◽

Case Control ◽

Non Hodgkin Lymphoma ◽

History Of ◽

Control Study

Objectives. To assess whether there are shared exposures associated with Sjogren’s syndrome (SS), dry eye syndrome (DES), and B-cell non-Hodgkin lymphoma (B-NHL), in order to determine whether they are etiologically related. Methods. In a clinic-based case-control study, 702 participants (91 SS, 120 DES, 211 (age and sex frequency-matched) controls, and 280 B-NHL cases) were recruited and interviewed regarding exposures, medical history, and family history. Results. Female predominance was noted in SS (ratio 9.2 : 1). Eye dryness was severest in SS compared to DES and controls (P<0.001). Compared to controls, alcohol consumption was inversely associated with NHL, DES, and SS (odds ratio OR=0.47, 95% confidence interval (CI): 0.31-0.71; OR=0.54, 95% CI: 0.33-0.88; and OR=0.26, 95% CI: 0.14-0.49, respectively), while a previous history of infection requiring hospitalization was positively associated with all three conditions: NHL (OR=1.92; 95% CI: 1.23-2.99), DES (OR=3.29; 95% CI: 1.97-5.47), and SS (OR=4.74; 95% CI: 2.66-8.44). NHL patients were more likely to report first-degree relatives with hematologic cancer, while having first-degree relatives with an autoimmune disease (AID) was associated with SS (OR=5.25; 95% CI: 2.59-10.63) and DES (OR=3.55; 95% CI: 1.83-6.91) compared to controls. Conclusions. Some exposures are associated with all three conditions (such as an inverse association with alcohol consumption and a positive association with serious past infection), while a family history of AID appears to be shared by DES and SS, but not NHL subjects. Shared risk factors for all three conditions indicate possible mutual etiological pathways.

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