scholarly journals Influence of vitamin K2 on lipid precursors of inflammation and fatty acids pathway activities in HepG2 cells

2021 ◽  
Vol 100 (7-8) ◽  
pp. 151188
Author(s):  
Adrian Kołakowski ◽  
Piotr Franciszek Kurzyna ◽  
Wiktor Bzdęga ◽  
Hubert Żywno ◽  
Ewa Harasim-Symbor ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Hepg2 Cells ◽  
Vitamin K2

Vitamin K2 inhibits the proliferation of HepG2 cells by up-regulating the transcription of p21 gene

2007 ◽  
Vol 37 (5) ◽  
pp. 360-365 ◽  
Author(s):  
Weidong Liu ◽  
Hideji Nakamura ◽  
Teruhisa Yamamoto ◽  
Naoto Ikeda ◽  
Masaki Saito ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Vitamin K2

Vitamin K2 colonic and ileal in vivo absorption: bile, fatty acids, and pH effects on transport.

1977 ◽  
Vol 233 (2) ◽  
pp. E124 ◽  
Author(s):  
D Hollander ◽  
E Rim ◽  
P E Ruble
Keyword(s):  
Fatty Acids ◽  
Bile Salt ◽  
Vitamin K ◽  
Salt Concentration ◽  
Absorption Rate ◽  
Vitamin K2 ◽  
Dietary Vitamin ◽  
Hydrogen Ion Concentration ◽  
Bile Salt Concentration

Colonic and ileal absorption of vitamin K2 ([2-methyl-3H]menaquinone-9) was investigated in the conscious rat. When the absorption rate was plotted against the perfusate concentration, a linear relationship was found between these two parameters in the ileum and colon. The absorption rate of menaquinone by the ileum was increased as the bile salt concentration, degree of unsaturation of the added long-chain fatty acids, hydrogen ion concentration, and perfusate flow rates were increased. Colonic menaquinone absorption decreased as the bile salt concentration was increased. Menaquinone colonic absoprtion increased as the pH decreased, but no change was noted as the perfusion rate was increased. The present experimental observations in vivo, coupled with prior observations in vitro, indicate that absorption of menaquinone by the ileum and colon occurs by a passive diffusion process that is modified by variations in the perfusate bile salt concentration, the presence of unsaturated fatty acids, and the perfusate pH. The present observations indicate that the mammalian colon and terminal ileum can provide a constant source of vitamin K to aid hemostasis despite episodic lack of dietary vitamin K.

Odd-Chain Fatty Acids Predict Insulin Sensitivity in People with T2DM and Protect HepG2 Cells from Palmitate-Induced Insulin Resistance Via PPARα

2016 ◽  
Vol 100 ◽  
pp. S174
Author(s):  
Ogwu John Ikwuobe ◽  
Karan Rana ◽  
James Brown ◽  
Chathyan Pararasa ◽  
Kiran Shabir ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Hepg2 Cells ◽  
Odd Chain Fatty Acids ◽  
Chain Fatty Acids

scholarly journals Free Fatty Acids Impair FGF21 Action in HepG2 Cells

2015 ◽  
Vol 37 (5) ◽  
pp. 1767-1778 ◽  
Author(s):  
Mohamed Asrih ◽  
Christophe Montessuit ◽  
Jacques Philippe ◽  
François R. Jornayvaz
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Lipid Metabolism ◽  
Free Fatty Acids ◽  
Hepg2 Cells ◽  
Lipid Lowering ◽  
Fibroblast Growth Factor 21 ◽  
Beneficial Effects ◽  
Positive Effects

Background/Aims: Fibroblast growth factor 21 (FGF21) is a key mediator of glucose and lipid metabolism. However, the beneficial effects of exogenous FGF21 administration are attenuated in obese animals and humans with elevated levels of circulating free fatty acids (FFA). Methods: We investigated in vitro how FFA impact FGF21 effects on hepatic lipid metabolism. Results: In the absence of FFA, FGF21 reduced lipogenesis and increased lipid oxidation in HepG2 cells. Inhibition of lipogenesis was associated with a down regulation of SREBP-1c, FAS and SCD1. The lipid-lowering effect was associated with AMPK and ACC phosphorylation, and up regulation of CPT-1α expression. Further, FGF21 treatment reduced TNFα gene expression, suggesting a beneficial action of FGF21 on inflammation. In contrast, the addition of FFA abolished the positive effects of FGF21 on lipid metabolism. Conclusion: In the absence of FFA, FGF21 improves lipid metabolism in HepG2 cells and reduces the inflammatory cytokine TNFα. However, under high levels of FFA, FGF21 action on lipid metabolism and TNFα gene expression is impaired. Therefore, FFA impair FGF21 action in HepG2 cells potentially through TNFα.

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