Langerhans cell histiocytosis as differential diagnosis of a mediastinal tumor

On HRCT scans, lung cysts are characterized by rounded areas of low attenuation in the lung parenchyma and a well-defined interface with the normal adjacent lung. The most common cystic lung diseases are lymphangioleiomyomatosis, Langerhans cell histiocytosis, and lymphocytic interstitial pneumonia. In a retrospective analysis of the HRCT findings in 50 patients diagnosed with chronic paracoccidioidomycosis, we found lung cysts in 5 cases (10%), indicating that patients with paracoccidioidomycosis can present with lung cysts on HRCT scans. Therefore, paracoccidioidomycosis should be included in the differential diagnosis of cystic lung diseases.

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Erdheim—Chester Disease

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347540300700206 ◽

2003 ◽

Vol 7 (2) ◽

pp. 129-132

Author(s):

Susan E. Lenahan ◽

Klaus F. Helm ◽

Kenneth D. Hopper

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Morbidity And Mortality ◽

Significant Morbidity ◽

Erdheim Chester Disease ◽

Pathologic Findings ◽

Erdheim Chester ◽

Chester Disease

Background: Erdheim–Chester disease is a rare non-Langerhans' cell histiocytosis. Objective: This case report is presented to familiarize clinicians with Erdheim–Chester disease and its differential diagnosis. Results and Conclusion: Erdheim–Chester disease presents with unique clinical and pathologic findings. Its xanthoma-like lesions can cause significant morbidity and mortality.

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Including Langerhans cell histiocytosis in the differential diagnosis of skin tumors with osteoclast-like multinucleated giant cells

Journal of Cutaneous Pathology ◽

10.1111/cup.12954 ◽

2017 ◽

Vol 44 (7) ◽

pp. 659-661

Author(s):

Tina Ho ◽

Jennifer Oliver-Krasinski ◽

Pierre Russo ◽

Jesse Taylor ◽

Jenna Streicher ◽

...

Keyword(s):

Differential Diagnosis ◽

Langerhans Cell Histiocytosis ◽

Giant Cells ◽

Langerhans Cell ◽

Skin Tumors ◽

Multinucleated Giant Cells

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Problems in Differential Diagnosis of Non-Langerhans Cell Histiocytosis with Pituitary Involvement: Case Report and Review of Literature

Endocrine Pathology ◽

10.1385/ep:13:4:361 ◽

2002 ◽

Vol 13 (4) ◽

pp. 361-368 ◽

Cited By ~ 15

Author(s):

Rene Mahnel ◽

Khing Hiong Tan ◽

Rudolf Fahlbusch ◽

Benedikt Volk ◽

Dieter Lüdecke ◽

...

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Review Of Literature

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Gastrointestinal Tract Involvement of Langerhans Cell Histiocytosis: Concerning Point of Diagnosis

Journal of Health Science and Medical Research ◽

10.31584/jhsmr.2020753 ◽

2020 ◽

Author(s):

Shevachut Chavananon ◽

Pornpun Sripornsawan ◽

Thirachit Chotsampancharoen

Keyword(s):

Differential Diagnosis ◽

Amino Acid ◽

Gastrointestinal Tract ◽

Antibiotic Treatment ◽

Langerhans Cell Histiocytosis ◽

Multimodality Treatment ◽

Skin Lesions ◽

Langerhans Cell ◽

Bloody Diarrhea ◽

Tract Involvement

An 8-month-old girl presented with chronic mucous bloody diarrhea for 3 months. She was diagnosed as infective gastroenteritis and did not improve after antibiotic treatment. Three months subsequently, she was diagnosed with allergic gastroenteritis after developing generalized skin rash and was treated with amino acid-based formula but the symptoms of diarrhea deteriorated. The results of a biopsy of the gastrointestinal tract and skin lesions confirmed the diagnosis of Langerhans cell histiocytosis. Although Langerhans cell histiocytosis is uncommon with gastrointestinal tract involvement, Langerhans cell histiocytosis should be listed in the differential diagnosis for patients who present with chronic mucous bloody diarrhea that is unresponsive to multimodality treatment.

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Langerhans cell histiocytosis of a metatarsal bone in an adult female

BMJ Case Reports ◽

10.1136/bcr-2019-231343 ◽

2019 ◽

Vol 12 (10) ◽

pp. e231343 ◽

Cited By ~ 1

Author(s):

Abhishek Vaish ◽

Raju Vaishya ◽

Lokesh Kumar Singh ◽

Vikas Kashyap

Keyword(s):

Differential Diagnosis ◽

Langerhans Cell Histiocytosis ◽

Case Reports ◽

Metatarsal Bone ◽

Langerhans Cell ◽

Malignant Tumours ◽

Foot Bones ◽

Lytic Lesions ◽

Small Bones ◽

Spontaneous Onset

Langerhans cell histiocytosis (LCH) commonly occurs in children. It mimics infection and many benign and malignant tumours. This disease mainly involves the spine, skull and long bones, and its incidence is sporadic in the small bones of the foot and hand. We could not find any case reports with the involvement of a metatarsal bone, and hence, awareness about its possibility is essential to suspect it as a differential diagnosis of lytic lesions in the foot bones and therefore treat it judiciously. We have reported a case of a 35-year-old woman with spontaneous onset of pain over her right foot for the last year. An extensive curettage was performed, where the histology confirmed the features of LCH. Awareness about this entity and its differential diagnosis may help to clinch and early diagnosis and to treat effectively.

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Isolated tumorous Langerhans cell histiocytosis of the brainstem: a diagnostic and therapeutic challenge

Journal of Neurosurgery Pediatrics ◽

10.3171/2013.6.peds13132 ◽

2013 ◽

Vol 12 (3) ◽

pp. 258-261 ◽

Cited By ~ 6

Author(s):

Amey Savardekar ◽

Manjul Tripathi ◽

Deepak Bansal ◽

Kim Vaiphei ◽

Sunil K. Gupta

Keyword(s):

Differential Diagnosis ◽

Diabetes Insipidus ◽

Rapid Growth ◽

Langerhans Cell Histiocytosis ◽

Histopathological Examination ◽

S100 Protein ◽

Langerhans Cell ◽

Rare Entity ◽

Diagnostic Features ◽

Chemotherapeutic Regimen

Langerhans cell histiocytosis (LCH) of the CNS is a rare entity, known to involve primarily the hypothalamicpituitary region, with the clinical hallmark of diabetes insipidus. There have been a few reports of CNS LCH involving the brainstem as intraparenchymal enhancing lesions, but this has never been the presenting complaint of LCH. The authors report on a 7-year-old boy who presented with right cerebellopontine syndrome, in whom a well-defined, solid, enhancing lesion in the brainstem was diagnosed. Clinicoradiological differential diagnosis included glioma and tuberculosis. Biopsy revealed atypical histiocytes positive for CD68, CD1a, and S100 protein; these are the diagnostic features of LCH on histopathological examination. The rapid growth of the lesion was controlled with a chemotherapeutic regimen of cladribine.

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Diagnosis and Intralesional Corticotherapy in Oral Ulcers Occurring as the Sole Manifestation of Langerhans Cell Histiocytosis. A Case Report

The Open Dentistry Journal ◽

10.2174/1874210601610010330 ◽

2016 ◽

Vol 10 (1) ◽

pp. 330-337 ◽

Cited By ~ 1

Author(s):

Liane Gambirazi ◽

Tatiana Libório ◽

Fábio Nunes ◽

Norberto Sugaya ◽

Dante Migliari

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Lymph Nodes ◽

Oral Mucosa ◽

Therapeutic Approach ◽

Langerhans Cell Histiocytosis ◽

Immunohistochemical Analysis ◽

Langerhans Cell ◽

Oral Ulcers

This article reports a case of oral mucosa lesions as the sole manifestation in Langerhans cell histiocytosis (LCH). This is a very uncommon manifestation of LCH since this disease preferably affects the bones with frequent involvement of the jaws. LCH may also involve other organs, particularly the lungs, liver, lymph nodes, and skin. The highlights of this report are the differential diagnosis, immunohistochemical analysis and, mostly, the therapeutic approach.

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