Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

2019 ◽  
Vol 161 ◽  
pp. 445-455 ◽  
Author(s):  
Xinyu Li ◽  
Chengzhe Wu ◽  
Xin Lin ◽  
Xuerong Cai ◽  
Linyi Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer

2017 ◽  
Vol 61 (1) ◽  
Author(s):  
Jessica R. Gutierrez-Cano ◽  
Pradip D. Nahide ◽  
Velayudham Ramadoss ◽  
Yuvraj Satkar ◽  
Rafael Ortiz-Alvarado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cultured Cells ◽  
Biological Evaluation ◽  
Doxorubicin Treatment ◽  
P Glycoprotein ◽  
Molecular Action ◽  
Mortality Effect ◽  
Kinase Phosphorylation ◽  
Synthesis And Biological Evaluation ◽  
Cultured Tumor Cells

<p>A series of new 3,4-diarylmaleimides were synthesized in an optimized and efficient lineal sequence of three steps, starting from commercial maleimide. The biological evaluation of these compounds as enhancers (activity modulators) in the co-administration with doxorubicin treatment in breast cancer cells directly obtained from a patient, were essayed. The cancerous tissue BT026-512N was provided by the National Institute of Cancerology (INCAN) of México. This tissue was obtained by biopsy from a patient diagnosed with stage IIB ductal breast cancer. The results obtained in the assays, show decreased cell viability on the cultured cells for all of the maleimides synthesized in combinatorial administration with doxorubicin. The highest mortality effect was determined for maleimides <strong>9</strong> and <strong>29</strong> increased in close to three times the effect compared with treatment using only doxorubicin. Based on previous functionalized maleimides core reports and Molinspiration chemoinformatic analysis, these results could possibly point out to the Pg-p glycoprotein as bio-molecular action target of maleimides by kinase phosphorylation-inhibition, although more experimental data is necessary.</p>

Synthesis and biological evaluation of resveratrol derivatives with anti‐breast cancer activity

2020 ◽  
Vol 353 (7) ◽  
pp. 2000044 ◽  
Author(s):  
Mei‐Fang Yang ◽  
Xu Yao ◽  
Li‐Mei Chen ◽  
Jin‐Ying Gu ◽  
Ze‐Hua Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Evaluation ◽  
Resveratrol Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Cancer Activity

The Synthesis and Biological Evaluation of Anithiactin A/Thiasporine C and Analogues

2015 ◽  
Vol 68 (12) ◽  
pp. 1829 ◽  
Author(s):  
Richard A. Lamb ◽  
Michael P. Badart ◽  
Brooke E. Swaney ◽  
Sinan Gai ◽  
Sarah K. Baird ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Cell Lines ◽  
Breast Cancer Cell ◽  
Phenyl Group ◽  
Biological Evaluation ◽  
Breast Cancer Cell Lines ◽  
High Concentration ◽  
Structural Requirements ◽  
Synthesis And Biological Evaluation

The synthesis of anithiactin A has been achieved in four steps. Several closely related analogues were synthesised and their biological activity against colon and breast cancer cell lines evaluated. Anithiactin A was found not to be cytotoxic even at a high concentration (100 μM); however, two 4-substituted phenyl thiazoles were found to be moderately cytotoxic at 10 μM. Based on these results, 4-substitution on the phenyl group appears to be critical for cytotoxicity. However, the exact electronic and structural requirements are unclear.

scholarly journals Design, synthesis, and biological evaluation of new 6,N2-diaryl-1,3,5-triazine-2,4-diamines as anticancer agents selectively targeting triple negative breast cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (43) ◽  
pp. 25517-25528
Author(s):  
Ahmad Junaid ◽  
Felicia Phei Lin Lim ◽  
Edward R. T. Tiekink ◽  
Anton V. Dolzhenko
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Anticancer Agents ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
3D Qsar ◽  
Qsar Model ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

New highly potent and selective 6,N2-diaryl-1,3,5-triazine-2,4-diamines were designed and prepared using the 3D-QSAR model developed earlier.

Design, synthesis and biological evaluation of 2-(phenoxymethyl)-5-phenyl-1,3,4-oxadiazole derivatives as anti-breast cancer agents

2019 ◽  
Vol 168 ◽  
pp. 1-10 ◽  
Author(s):  
K. Lakshmithendral ◽  
K. Saravanan ◽  
R. Elancheran ◽  
K. Archana ◽  
N. Manikandan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Oxadiazole Derivatives ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells

2017 ◽  
Vol 139 ◽  
pp. 305-324 ◽  
Author(s):  
Anver Basha Shaik ◽  
Garikapati Koteswara Rao ◽  
G. Bharath Kumar ◽  
Nibeditha Patel ◽  
Vangala Santhosh Reddy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Evaluation ◽  
Mtor Pathway ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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