Characterisation of ultrasound contrast agents for subharmonic imaging for use in quantitative dynamic contrast enhanced ultrasound

Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been proposed as a method for isolating ultrasound microbubble signals while suppressing surrounding tissue signals. In this paper, we summarize recent advances in the use of subharmonic imagingin vivo. These advances include the implementation of subharmonic imaging on linear and curvilinear arrays, intravascular probes, and three-dimensional probes for breast, renal, liver, plaque, and tumor imaging.

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Window-Modulated Compounding Nakagami Parameter Ratio Approach for Assessing Muscle Perfusion with Contrast-Enhanced Ultrasound Imaging

Sensors ◽

10.3390/s20123584 ◽

2020 ◽

Vol 20 (12) ◽

pp. 3584

Author(s):

Huang-Chen Lin ◽

Shyh-Hau Wang

Keyword(s):

Contrast Agents ◽

Ultrasound Imaging ◽

Ultrasound Contrast Agents ◽

Muscle Disease ◽

Contrast Enhanced Ultrasound ◽

Time Intensity Curve ◽

Muscle Perfusion ◽

Ultrasound Contrast ◽

Parameter Ratio ◽

Contrast Enhanced

The assessment of microvascular perfusion is essential for the diagnosis of a specific muscle disease. In comparison with the current available medical modalities, the contrast-enhanced ultrasound imaging is the simplest and fastest means for probing the tissue perfusion. Specifically, the perfusion parameters estimated from the ultrasound time-intensity curve (TIC) and statistics-based time–Nakagami parameter curve (TNC) approaches were found able to quantify the perfusion. However, due to insufficient tolerance on tissue clutters and subresolvable effects, these approaches remain short of reproducibility and robustness. Consequently, the window-modulated compounding (WMC) Nakagami parameter ratio imaging was proposed to alleviate these effects, by taking the ratio of WMC Nakagami parameters corresponding to the incidence of two different acoustic pressures from an employed transducer. The time–Nakagami parameter ratio curve (TNRC) approach was also developed to estimate perfusion parameters. Measurements for the assessment of muscle perfusion were performed from the flow phantom and animal subjects administrated with a bolus of ultrasound contrast agents. The TNRC approach demonstrated better sensitivity and tolerance of tissue clutters than those of TIC and TNC. The fusion image with the WMC Nakagami parameter ratio and B-mode images indicated that both the tissue structures and perfusion properties of ultrasound contrast agents may be better discerned.

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An EFSUMB Introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for Quantification of Tumour Perfusion

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0032-1313026 ◽

2012 ◽

Vol 33 (04) ◽

pp. 344-351 ◽

Cited By ~ 155

Author(s):

C. Dietrich ◽

M. Averkiou ◽

J.-M. Correas ◽

N. Lassau ◽

E. Leen ◽

...

Keyword(s):

Contrast Agents ◽

Image Interpretation ◽

Ultrasound Contrast Agents ◽

Ultrasound Images ◽

Contrast Enhanced Ultrasound ◽

Dynamic Contrast Enhanced ◽

Technical Requirements ◽

Contrast Enhanced ◽

Microbubble Contrast Agents ◽

Safety Considerations

AbstractDynamic Contrast Enhanced Ultrasound (DCE-US) is an imaging technique that utilizes microbubble contrast agents in diagnostic ultrasound. The EFSUMB guidelines published in 2004, updated in 2008 and 2011 focused on the use of DCE-US, including essential technical requirements, training, investigational procedures and steps, guidance on image interpretation, established and recommended clinical indications and safety considerations. However the quantification of images acquired with ultrasound contrast agents (UCAs) is not discussed in the guidelines. The purpose of this EFSUMB document is to provide some recommendations and descriptions of the quantification of ultrasound images, technical requirements for analysis of time-intensity curves (TICs), methodology for data analysis, and interpretation of the results.

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EFSUMB 2020 Proposal for a Contrast-Enhanced Ultrasound-Adapted Bosniak Cyst Categorization – Position Statement

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/a-1300-1727 ◽

2020 ◽

Author(s):

Vito Cantisani ◽

Michele Bertolotto ◽

Dirk-André Clevert ◽

Jean-Michel Correas ◽

Francesco Maria Drudi ◽

...

Keyword(s):

Contrast Agents ◽

Task Force ◽

Position Statement ◽

Ultrasound Contrast Agents ◽

Renal Lesions ◽

Ultrasound Contrast ◽

Contrast Enhanced ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography ◽

Cystic Renal Lesions

AbstractThe well-established Bosniak renal cyst classification is based on contrast-enhanced computed tomography determining the malignant potential of cystic renal lesions. Ultrasound has not been incorporated into this pathway. However, the development of ultrasound contrast agents coupled with the superior resolution of ultrasound makes it possible to redefine the imaging of cystic renal lesions. In this position statement, an EFSUMB Expert Task Force reviews, analyzes, and describes the accumulated knowledge and limitations and presents the current position on the use of ultrasound contrast agents in the evaluation of cystic renal lesions.

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Intraoperative Contrast-Enhanced Ultrasound for Brain Tumor Surgery

Neurosurgery ◽

10.1227/neu.0000000000000301 ◽

2014 ◽

Vol 74 (5) ◽

pp. 542-552 ◽

Cited By ~ 93

Author(s):

Francesco Prada ◽

Alessandro Perin ◽

Alberto Martegani ◽

Luca Aiani ◽

Luigi Solbiati ◽

...

Keyword(s):

Brain Tumor ◽

Real Time ◽

Large Scale ◽

Brain Lesion ◽

Ultrasound Contrast Agent ◽

Ultrasound Contrast Agents ◽

Brain Lesions ◽

Contrast Enhanced Ultrasound ◽

Ultrasound Contrast ◽

Contrast Enhanced

Abstract BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a dynamic and continuous modality that offers a real-time, direct view of vascularization patterns and tissue resistance for many organs. Thanks to newer ultrasound contrast agents, CEUS has become a well-established, live-imaging technique in many contexts, but it has never been used extensively for brain imaging. The use of intraoperative CEUS (iCEUS) imaging in neurosurgery is limited. OBJECTIVE: To provide the first dynamic and continuous iCEUS evaluation of a variety of brain lesions. METHODS: We evaluated 71 patients undergoing iCEUS imaging in an off-label setting while being operated on for different brain lesions; iCEUS imaging was obtained before resecting each lesion, after intravenous injection of ultrasound contrast agent. A semiquantitative, offline interobserver analysis was performed to visualize each brain lesion and to characterize its perfusion features, correlated with histopathology. RESULTS: In all cases, the brain lesion was visualized intraoperatively with iCEUS. The afferent and efferent blood vessels were identified, allowing evaluation of the time and features of the arterial and venous phases and facilitating the surgical strategy. iCEUS also proved to be useful in highlighting the lesion compared with standard B-mode imaging and showing its perfusion patterns. No adverse effects were observed. CONCLUSION: Our study is the first large-scale implementation of iCEUS in neurosurgery as a dynamic and continuous real-time imaging tool for brain surgery and provides the first iCEUS characterization of different brain neoplasms. The ability of CEUS to highlight and characterize brain tumor will possibly provide the neurosurgeon with important information anytime during a surgical procedure.

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7 Ultrasound Contrast Agents and Contrast-Enhanced Ultrasonography

Endoscopic Ultrasound ◽

10.1055/b-0034-52437 ◽

2006 ◽

Keyword(s):

Contrast Agents ◽

Ultrasound Contrast Agents ◽

Ultrasound Contrast ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography

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Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2020 – WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/a-1177-0530 ◽

2020 ◽

Vol 41 (05) ◽

pp. 562-585 ◽

Cited By ~ 6

Author(s):

Christoph F. Dietrich ◽

Christian Pállson Nolsøe ◽

Richard G. Barr ◽

Annalisa Berzigotti ◽

Peter N Burns ◽

...

Keyword(s):

Contrast Agents ◽

Good Clinical Practice ◽

The United States ◽

International Perspective ◽

Ultrasound Contrast Agents ◽

European Federation ◽

Contrast Enhanced Ultrasound ◽

Contrast Enhanced ◽

United States Food ◽

Recent Developments

AbstractThe present, updated document describes the fourth iteration of recommendations for the hepatic use of contrast enhanced ultrasound (CEUS), first initiated in 2004 by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB). The previous updated editions of the guidelines reflected changes in the available contrast agents and updated the guidelines not only for hepatic but also for non-hepatic applications.The 2012 guideline requires updating as previously the differences of the contrast agents were not precisely described and the differences in contrast phases as well as handling were not clearly indicated. In addition, more evidence has been published for all contrast agents. The update also reflects the most recent developments in contrast agents, including the United States Food and Drug Administration (FDA) approval as well as the extensive Asian experience, to produce a truly international perspective.These guidelines and recommendations provide general advice on the use of ultrasound contrast agents (UCA) and are intended to create standard protocols for the use and administration of UCA in liver applications on an international basis to improve the management of patients.

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Book Reviews

Acta Radiologica ◽

10.1080/02841859809172180 ◽

1998 ◽

Vol 39 (2) ◽

pp. 208-210

Keyword(s):

New York ◽

Differential Diagnosis ◽

Contrast Agents ◽

Acute Abdomen ◽

Ultrasound Contrast Agents ◽

Clinical Imaging ◽

Ultrasound Contrast ◽

Contrast Enhanced ◽

Contrast Enhanced Mri

Manual of Radiology. Acute Problems and Essential Procedures.: Edited by J. Eng. 351 pages. Lippincott-Raven 1997. ISBN 0-397-51768-8. Price, softbound: USD 34.50. Reviewed by Rickard Nyman Contrast Sonography in Gynaecology. Edited by F. Degerhardt. 96 pages, 99 illustrations, 5 coloured graphs, 17 tables. Thieme Verlag 1996. ISBN 0-86577-704-7. Price: DEM 148. Reviewed by Paul Nilsson Clinical Imaging, an Atlas of Differential Diagnosis. 3rd edn. Edited by R. L. Eisenberg. 1246 pages, Lippincott-Raven 1997. ISBN 0-397-51679-7. Price, hardbound: USD 206. Reviewed by Rickard Nyman Basic Radiology. Edited by M. Y. M. Chen et al. McGraw-Hill 1996. ISBN 0-07-011148-0. Price: GBP 34.50. Reviewed by Sven Nilsson. Contrast-Enhanced MRI of the Breast, 2nd den. by S. H. Heywang-Kobrunner and R. Beck. 229 pages. Springer-Verlag 1996. ISBN 3-540-58975-9. Price, hardcover: DEM 148. Reviewed by Per Skaane Radiology of Trauma. Edited by M. Heller and A. Fink. Springer-Verlag 1997. ISBN 3-540-5932-1. Price: DEM 298. Reviewed by Rickard Nyman CT and Sonography of the Acute Abdomen, 2nd edn. by R. Brooke Jeffrey Jr and Philip W. Ralls. Lippincott-Raven, New York 1996. ISBN 0-7817-0287-9. Price: USD 144. Reviewed by Anders Elvin Ultrasound Contrast Agents. Edited by B. Goldberg. Martin Dunitz Publishers, London 1996. ISBN 1-85317-283-9. Hardcover. Reviewed by Pave1 Pinkava and Anders Elvin

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How to perform Contrast-Enhanced Ultrasound (CEUS)

Ultrasound International Open ◽

10.1055/s-0043-123931 ◽

2018 ◽

Vol 04 (01) ◽

pp. E2-E15 ◽

Cited By ~ 70

Author(s):

Christoph Dietrich ◽

Michalakis Averkiou ◽

Michael Nielsen ◽

Richard Barr ◽

Peter Burns ◽

...

Keyword(s):

Decision Making ◽

Personal Experience ◽

Clinical Decision Making ◽

Clinical Decision ◽

Ultrasound Contrast Agents ◽

Contrast Enhanced Ultrasound ◽

Technical Parameters ◽

Ultrasound Contrast ◽

Published Evidence ◽

Contrast Enhanced

Abstract“How to perform contrast-enhanced ultrasound (CEUS)” provides general advice on the use of ultrasound contrast agents (UCAs) for clinical decision-making and reviews technical parameters for optimal CEUS performance. CEUS techniques vary between centers, therefore, experts from EFSUMB, WFUMB and from the CEUS LI-RADS working group created a discussion forum to standardize the CEUS examination technique according to published evidence and best personal experience. The goal is to standardise the use and administration of UCAs to facilitate correct diagnoses and ultimately to improve the management and outcomes of patients.

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Эхокардиография с контрастным усилением для оценки сократимости левого желудочка у больного с блокадой левой ножки пучка Гиса

Ultrasound & Functional Diagnostics ◽

10.24835/1607-0771-2017-6-59-65 ◽

2017 ◽

pp. 59-65

Keyword(s):

Contrast Agents ◽

Left Bundle Branch Block ◽

Wall Motion ◽

Regional Wall Motion ◽

Ultrasound Contrast Agents ◽

Bundle Branch Block ◽

Regional Wall ◽

Ultrasound Contrast ◽

Contrast Enhanced ◽

Contrast Enhanced Echocardiography

Представлен клинический случай использования эхокардиографии с контрастным усилением в визуализации левого желудочка с целью исключения нарушений локальной сократимости у пациента с впервые возникшей полной блокадой левой ножки пучка Гиса. При рутинном двумерном эхокардиографическом исследовании на основе сниженной амплитуды движения стенки в средних перегородочных сегментах были заподозрены нарушения локальной сократимости левого желудочка. Эхокардиография с контрастным усилением позволила отчетливо визуализировать эндокардиальную и эпикардиальную поверхности миокарда и на основании анализа систолического утолщения миокарда исключить наличие нарушений локальной сократимости левого желудочка. Ключевые слова: эхокардиография, эхокардиография с контрастным усилением, внутривенные ультразвуковые контрастные препараты, блокада левой ножки пучка Гиса, нарушения локальной сократимости, echocardiography, contrast-enhanced echocardiography, intravenous ultrasound contrast agents, left bundle branch block, regional wall motion abnormality

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