Application value of conventional ultrasound and real-time shear wave elastography in patients with type 2 diabetic polyneuropathy

Abstract Background and aims Painful polyneuropathy (PPN) is a disabling complication of diabetes. This study aims to determine its prevalence and relationship with Quality of Life (QoL) in a nationwide prospective cohort of incident recently diagnosed Danish type 2 diabetic patients. Methods We sent a detailed questionnaire on neuropathy, pain and QoL to 6726 patients prospectively enrolled from general practitioners and hospital specialist outpatient clinics into the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients who reported pain in both feet and a score ≥3 on the Douleur Neuropathique (DN4) questionnaire were considered to have possible PPN. QoL and pain intensity were measured on a numeric rating scale (NRS, 0–10). The Michigan Neuropathy Screening Instrument (MNSI) was used to assess neuropathy. Results A total of 5371 (79.8%) returned a complete questionnaire. 848 (15.8%) recently diagnosed type 2 diabetic patients reported pain in both feet. Of the 619 patients with pain who completed the DN4 questionnaire, 404 (65.2%) had a DN4 score ≥ 3, corresponding to a prevalence in the total population of possible PPN of 10.3%. Mean pain intensity was 5.2 (SD 2.2) and 89% had a MNSI score ≥ 3. Patients with possible PPN had a substantially lower QoL score than those without PPN (median QoL score 6 versus 8 (p < 0.001)), also when correcting for MNSI score. Conclusions Ten percent of newly diagnosed type 2 diabetic patients in Denmark had possible PPN. Patients with PPN had lower QoL than patients without PPN.

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Letter: Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients (Diabetes Metab J 2011;35:390-6)

Diabetes & Metabolism Journal ◽

10.4093/dmj.2011.35.5.558 ◽

2011 ◽

Vol 35 (5) ◽

pp. 558 ◽

Cited By ~ 1

Author(s):

Sun-Hye Ko ◽

Seung-Hyun Ko

Keyword(s):

Diabetic Polyneuropathy ◽

Cardiovascular Complications ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Feasibility of transient elastography versus real-time two-dimensional shear wave elastography in difficult-to-scan patients

Scandinavian Journal of Gastroenterology ◽

10.1080/00365521.2016.1193217 ◽

2016 ◽

Vol 51 (11) ◽

pp. 1354-1359 ◽

Cited By ~ 8

Author(s):

Benjamin Staugaard ◽

Peer Brehm Christensen ◽

Belinda Mössner ◽

Janne Fuglsang Hansen ◽

Bjørn Stæhr Madsen ◽

...

Keyword(s):

Real Time ◽

Shear Wave ◽

Transient Elastography ◽

Shear Wave Elastography ◽

Two Dimensional

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Which factors influence liver stiffness measured by real-time two dimensional shear wave elastography in patients on maintenance hemodialysis?

Croatian Medical Journal ◽

10.3325/cmj.2021.62.34 ◽

2021 ◽

Vol 62 (1) ◽

pp. 34-43

Author(s):

Danijela Zjačić Puljiz ◽

Ivana Kristina Delić Jukić ◽

Marko Puljiz ◽

Lučana Vicelić Čutura ◽

Iva Jerčić Martinić-Cezar ◽

...

Keyword(s):

Real Time ◽

Shear Wave ◽

Liver Stiffness ◽

Shear Wave Elastography ◽

Maintenance Hemodialysis ◽

Two Dimensional

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Diagnosis of experimental stetohepatosis using ultrasound shear wave elastography

Current Issues in Pharmacy and Medical Sciences ◽

10.12923/j.2084-980x/26.1/a.24 ◽

2015 ◽

Vol 26 (1) ◽

pp. 109-113

Keyword(s):

Insulin Resistance ◽

Shear Wave ◽

Shear Wave Elastography ◽

Mixed Diet ◽

Sweetened Condensed Milk ◽

Non Invasive ◽

Condensed Milk ◽

First Time ◽

Diagnosis Technique

According to available literature data, NAFLD may play crucial role in the pathogenesis of type 2 diabetes and other conditions connected with insulin resistance. In order to study the essence of the NAFLD, we have created an experimental model of the steatohepatosis. The mixed diet for 8 weeks consisting of standard food (47%), sweetened condensed milk (44%), vegetable oil (8%) and vegetable starch (1%) develops non-alcoholic steatohepatosis in the animals undergoing the experiment. The morphological signs of the non-alcoholic steatohepatosis comprised as follows in the hepatocytes of the rats undergoing the experiment: presence of fine-drop fattiness (fine-drop steatosis) and accumulation of fat vacuoles shifting the nucleus towards the cell peripheral. Substantial increase in the liver pulp of the animals undergoing the experiment defined using the ultrasound shear wave elastography technique is indicative of the presence of the non-alcoholic steatohepatosis. The ultrasound shear wave elastography technique can be used as a non-invasive diagnosis marker of the non-alcoholic steatohepatosis. The said diagnosis technique has been recommended for the first time.

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The impact of body position and exercise on the measurement of liver Young’s modulus by real-time shear wave elastography

Technology and Health Care ◽

10.3233/thc-213218 ◽

2021 ◽

pp. 1-10

Author(s):

Xia Jiang ◽

Li Li ◽

Hong-Yuan Xue

Keyword(s):

Healthy Volunteers ◽

Real Time ◽

Young’S Modulus ◽

Shear Wave ◽

Supine Position ◽

Young's Modulus ◽

Body Position ◽

Shear Wave Elastography ◽

Lateral Position ◽

Left Lateral Position

BACKGROUND: In the past ten years, liver biopsies have been used as a method to accurately diagnose the stage of fibrosis. OBJECTIVE: This study aimed to evaluate whether body position and exercise affect the measurement of liver Young’s modulus of healthy volunteers by real-time shear wave elastography (RT-SWE). Methods: RT-SWE was used to measure liver Young’s modulus in the supine and left lateral positions of 70 healthy volunteers at rest and measure the liver Young’s modulus in the lying position before exercise, and at zero, five, and ten minutes of rest after exercise. RESULTS: The liver Young’s modulus in the left lateral position was significantly higher than in the supine position (P< 0.05), and the measured value in the supine position was more stable than the left lateral position. The liver Young’s modulus measured at zero minutes after exercise was significantly higher than that measured before exercise (P< 0.05). The liver Young’s modulus measured at five minutes after exercise was significantly higher than that measured at zero minutes after exercise (P<0.05) and was not statistically different from the measured value before exercise (P> 0.05). The liver Young’s modulus measured at ten minutes after exercise was significantly higher from that measured at zero minutes after exercise (P< 0.05) and was not statistically different from the measured value at five minutes after exercise (P> 0.05). CONCLUSION: Body position and exercise have a significant impact on the measurement of liver Young’s modulus. It is recommended that the examinees take a supine position during the measurement, and measurement should be conducted at least ten minutes after exercise.

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