scholarly journals SAT-469 EFFECT OF RITUXIMAB ON GROWTH AND BODY MASS INDEX IN CHILDHOOD STEROID DEPENDENT NEPHROTIC SYNDROME: A RETROSPECTIVE MULTI-CENTER REVIEW

2020 ◽  
Vol 5 (3) ◽  
pp. S196
Author(s):  
R. Sinha ◽  
A. Mukherjee ◽  
S. Banerjee ◽  
S. Pradhan
Keyword(s):  
Body Mass Index ◽  
Nephrotic Syndrome ◽  
Body Mass ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

MO1021HYPERTENSION IN CHILDHOOD MINIMAL CHANGE DISEASE: IGNORED, MISSED OR UNDER-DIAGNOSED?

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Sourabh Sharma ◽  
Neha Sharma
Keyword(s):  
Body Mass Index ◽  
Nephrotic Syndrome ◽  
Family History ◽  
Body Mass ◽  
Minimal Change Disease ◽  
Angiotensin Receptor Blockers ◽  
Tertiary Care ◽  
Minimal Change ◽  
Primary Nephrotic Syndrome ◽  
Steroid Dependent

Abstract Background and Aims Minimal change disease (MCD) is most common form of primary nephrotic syndrome (76.6% as per ISKDC) in children aged 1 to 10 years. As per current literature, blood pressure (BP) is usually normal in childhood MCD while in adults, 50% MCD cases are hypertensive. We hypothesized that hypertension is prevalent in childhood MCD also and most of cases are missed or under-diagnosed due to lack of BP monitoring, inappropriate BP cuff size (larger cuff will inaccurately show lower BP; cuff should cover 75% to 80% of arm circumference between antecubital fossa and axilla) or lack of knowledge about childhood hypertension criteria (systolic or diastolic BP> 95th percentile for age on ≥2 clinical visits at least 1 week apart). Method This cross-sectional study was performed from March 2018 to December 2020 at a tertiary care centre in India. Newly diagnosed and relapses of primary nephrotic syndrome (presumed MCD) in children aged 1 to 10 years were included in the study. All cases were subjected to careful BP monitoring and charting using appropriate BP cuff, while child is calm and relaxed, in quiet room with comfortable temperature and empty bladder. Three measurements were taken at 1 minute interals and taking average of last 2 measurements. Percentile charts for age and height were followed. Results fifty four cases of childhood MCD were studied. Thirty six cases (66.67%) were male. Mean age was 5.48 years (SD ±2.31). Thirty two cases (59.26%) were found to be hypertensive. Fourteen cases (43.75%) were relapses. Seven cases (21.87%) were steroid resistant nephrotic syndrome while three cases were steroid dependent. Five cases were already on calcineurin inhibitors when diagnosed of hypertension. There was family history of hypertension in 9 cases diagnosed of hypertension (p value 0.77). There was no correlation between occurrence of hypertension and degree of proteinuria, hypoalbuminemia or body mass index. All hypertensives were managed with angiotensin receptor blockers and regularly followed-up. Conclusion Results of our study are contrary to traditional belief that hypertension is not common in childhood MCD. Significant number of cases are hypertensive. Correct BP measurement and interpretation is necessary in each childhood MCD case. Its occurrence is not correlated with family history or degree of proteinuria, hypoalbuminemia or body mass index.

A case of a 7-year-old boy with steroid-dependent nephrotic syndrome who developed severe neutropenia three months after the administration of rituximab

2009 ◽  
Vol 22 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Ryugo Hiramoto ◽  
Shinsuke Matsumoto ◽  
Hironobu Eguchi ◽  
Yoshitaka Miyoshi ◽  
Isao Komori ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Severe Neutropenia ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Short-term efficacy of rituximab versus tacrolimus in steroid-dependent nephrotic syndrome

2011 ◽  
Vol 27 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Aditi Sinha ◽  
Arvind Bagga ◽  
Ashima Gulati ◽  
Pankaj Hari
Keyword(s):  
Nephrotic Syndrome ◽  
Short Term ◽  
Term Efficacy ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Mycophenolate sodium for children with frequently relapsing or steroid dependent nephrotic syndrome

2017 ◽  
Vol 54 (10) ◽  
pp. 885-886
Author(s):  
Kanika Kapoor ◽  
Abhijeet Saha ◽  
Manpreet Kaur ◽  
Nand Kishore Dubey ◽  
Ashish Datt Upadhyay
Keyword(s):  
Nephrotic Syndrome ◽  
Mycophenolate Sodium ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

scholarly journals The Efficacy and Safety of Rituximab for Childhood Steroid-Dependent Nephrotic Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Sidi Liu ◽  
Chuying Gui ◽  
Zhenzhen Lu ◽  
Huijie Li ◽  
Zhike Fu ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Randomized Clinical Trials ◽  
Remission Rate ◽  
Cochrane Library ◽  
Control Group ◽  
Efficacy And Safety ◽  
Steroid Dependent ◽  
Alternative Treatment Option ◽  
Control Study ◽  
Steroid Dependent Nephrotic Syndrome

Objectives: Rituximab (RTX), a possible alternative treatment option, is recognized as a new therapeutic hope for the treatment of steroid-dependent nephrotic syndrome (SDNS) in children. However, the efficacy and safety of RTX in the treatment of childhood SDNS are still controversial. The objective of this study was to evaluate the efficacy and safety of RTX treatment in children with SDNS.Study Design: Six randomized controlled trials (RCTs) and one retrospective comparative control study data from studies, performed before January 2021 were collected, from PubMed, Cochrane Library, Embase, and Web of Science. The studies evaluating the efficacy and safety of RTX in childhood SDNS were included.Results: Six RCTs and one retrospective comparative control study were included in our analysis. Compared with the control group, the RTX treatment group achieved a higher complete remission rate (OR = 5.21; 95% CI, 3.18–8.54; p < 0.00001), and we found significant differences between the two groups on serum albumin level (MD = 0.88; 95% CI, 0.43–1.33; p = 0.0001) and estimated glomerular filtration rate (MD = 6.43; 95% CI, 2.68–10.19; p = 0.0008). However, RTX treatment did not significantly lower serum creatinine levels nor did it significantly reduce the occurrence of proteinuria. In addition, we found no advantages with RTX on treatment safety.Conclusions: RTX has shown satisfactory characteristics in terms of efficacy and may be a promising treatment method for SDNS in children. However, the long-term effects have not been fully evaluated and should be further studied through randomized clinical trials.

scholarly journals A case report on usage of rituximab on complicated steroid-dependent nephrotic syndrome

2020 ◽  
Vol 10 (1) ◽  
pp. 130
Author(s):  
Shravan Jayachandran ◽  
S. Suwitha ◽  
A. Priya ◽  
K. Arun Chander
Keyword(s):  
Nephrotic Syndrome ◽  
Treatment Duration ◽  
Supportive Treatment ◽  
Childhood Disease ◽  
Steroid Dependent ◽  
The Status ◽  
Resistance Patterns ◽  
History Of ◽  
The Common ◽  
Steroid Dependent Nephrotic Syndrome

Nephrotic syndrome (NS) is one of the common yet challenging childhood disease. Treating NS with immunosuppressants like corticosteroids is typically effective. However, there are significant evidences which displayed resistance patterns to the former drugs. Here in this case, a male patient came to the nephrology department with the history of steroid dependant nephrotic syndrome with complaint of its infrequent relapse. The condition was complicated since, the patient was on multiple steroids even after which there were recurrent episodes of syndrome. Considering the status, Mycophenolate mofetil was added as a supportive treatment for the management of the disease along with steroids, still the outcome was unremarkable. Hence, rituximab was ordered (four cycles). The outcome this time was appreciable, rituximab administration produced a positive result. No events were recorded during the treatment duration. 

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