Electroanalysis of Candida albicans biofilms: a suitable real-time tool for antifungal testing

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Kayode Olaifa ◽  
Jasmina Nikodinovic-Runic ◽  
Biljana Glišić ◽  
Francesco Boschetto ◽  
Elia Marin ◽  
...  
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Emílio José T. Rodríguez Acosta ◽  
Luciana de Rezende Pinto ◽  
Márcia Graeff ◽  
Denise Madalena P. Spolidorio ◽  
...  

2018 ◽  
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2019 ◽  
Vol 27 ◽  
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Author(s):  
Beatriz H.D. Panariello ◽  
Marlise I. Klein ◽  
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Ana Cláudia Pavarina

2012 ◽  
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2002 ◽  
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Kacy VandeWalle ◽  
Gordon Ramage ◽  
Thomas F. Patterson ◽  
Brian L. Wickes ◽  
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ABSTRACT Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Caspofungin displayed potent in vitro activity against sessile C. albicans cells within biofilms, with MICs at which 50% of the sessile cells were inhibited well within the drug's therapeutic range. Scanning electron microscopy and confocal scanning laser microscopy were used to visualize the effects of caspofungin on preformed C. albicans biofilms, and the results indicated that caspofungin affected the cellular morphology and the metabolic status of cells within the biofilms. The coating of biomaterials with caspofungin had an inhibitory effect on subsequent biofilm development by C. albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections.


2012 ◽  
Vol 31 (9) ◽  
pp. 2237-2245 ◽  
Author(s):  
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J. L. Benton ◽  
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J. L. Rouse ◽  
...  

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181199 ◽  
Author(s):  
Guilherme Rodrigues Teodoro ◽  
Aline Vidal Lacerda Gontijo ◽  
Aline Chiodi Borges ◽  
Márcia Hiromi Tanaka ◽  
Gabriela de Morais Gouvêa Lima ◽  
...  

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