About cardiovascular effects associated with non-insulin antidiabetics: Importance of patient therapeutic education and spontaneous reporting of adverse effects

2017 ◽  
Vol 27 (4) ◽  
pp. 267-268
Author(s):  
Cristóbal Gallego Muñoz ◽  
Nieves Guerrero Navarro ◽  
Ana Candela Fajardo
Keyword(s):  
Adverse Effects ◽  
Spontaneous Reporting ◽  
Cardiovascular Effects ◽  
Therapeutic Education ◽  
Patient Therapeutic Education

scholarly journals Plaque erosion causing ST-elevation myocardial infarction after consumption of cannabis and N2O in a 27-year old man: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sarah Bär ◽  
Fabien Praz ◽  
Lorenz Räber
Keyword(s):  
Myocardial Infarction ◽  
Case Report ◽  
Adverse Effects ◽  
Cardiovascular Effects ◽  
Drug Eluting Stent ◽  
Culprit Lesion ◽  
Vascular Events ◽  
The Public ◽  
Plaque Erosion ◽  
First Case

Abstract Background The recreational drugs cannabis and nitrous oxide (N2O) are known for pro-atherogenic effects and are associated with an elevated risk of myocardial infarction. These cardiovascular effects might be underestimated by the public. Culprit-lesion composition of myocardial infarctions associated with cannabis and N2O has been unknown so far. This case report aims to raise the awareness of the adverse cardiovascular effects of cannabis and N2O and reports, for the first time, optical coherence tomography (OCT) findings of the culprit lesion. Case presentation This is a case report of a 27-year old man with anterior ST-segment-elevation myocardial infarction (STEMI) after intoxication with cannabis and N2O. Coronary angiography and OCT revealed plaque erosion with subsequent subtotal thrombotic occlusion of the left anterior descending artery that was successfully treated with 1 drug-eluting stent. The patient was symptom free at 6 months follow-up and had been able to abstain from drug consumption. Conclusions This is the first case to demonstrate the association between cannabis and N2O abuse and plaque erosion on OCT in a young man with STEMI. In contrast to smoking, whose adverse effects are well-known, the cardiovascular effects of cannabis and N2O might be underestimated. These adverse effects should gain more awareness in the public to prevent early vascular events in young adults.

Cardiovascular effects of non-cardiovascular drugs

ESC CardioMed ◽  
2018 ◽  
pp. 222-226
Author(s):  
Pauline Bosco-Levy ◽  
Julien Bezin ◽  
Francesco Salvo ◽  
Nicholas Moore
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Heart Rate ◽  
Cardiovascular Diseases ◽  
Adverse Effects ◽  
Cardiovascular Effects ◽  
Mechanisms Of Action ◽  
Cardiovascular Drugs ◽  
Vascular Bed ◽  
The Moment

Many drugs that were not designed to treat cardiovascular diseases may affect the cardiovascular system, causing adverse reactions. The objective of this chapter is to review in a systematic manner these adverse effects of non-cardiovascular drugs. The heart consists of four main entities that may be affected by non-cardiovascular drugs and lead to very different types of events: (1) the conduction tissue, that governs heart rate and rhythm, associated with arrhythmia and sudden death; (2) the endocardium and valves, associated with valvular disease and endocardial fibrosis; (3) the myocardium, which can directly or indirectly lead to heart failure; and (4) the coronary arteries, and in general the vascular bed, with myocardial ischaemia and infarction as main adverse events. These different elements may be affected by different drugs with different mechanisms of action, though some drugs may affect several components (e.g. myocardial infarction may result in heart failure). The objective of this chapter is not to provide exhaustive listings of all drugs ever associated with any of these events, which can be found online and will be obsolete the moment they are published, but an understanding of the typology of these events and their mechanism.

scholarly journals Post marketing surveillance of suspected adverse drug reactions through spontaneous reporting: current status, challenges and the future

2020 ◽  
Vol 11 ◽  
pp. 204209862093859 ◽  
Author(s):  
Muaed Alomar ◽  
Ali M Tawfiq ◽  
Nageeb Hassan ◽  
Subish Palaian
Keyword(s):  
Adverse Effects ◽  
Health Professionals ◽  
Healthcare Professionals ◽  
Spontaneous Reporting ◽  
Future Prospects ◽  
Innovative Strategies ◽  
Post Marketing Surveillance ◽  
The Future ◽  
Post Marketing ◽  
Reporting Programs

Background: To highlight the importance of spontaneous reporting programs in post marketing surveillance of medicines. Authors also aimed at providing various dimensions of spontaneous programs, including the strengths and weakness, and providing an insight on the future prospects of pharmacovigilance systems. Methods: Various literature related to post marketing surveillance and spontaneous reporting programs were reviewed and the relevant ones highlighting the strengths and weaknesses are summarized. A balance of information on strengths and weaknesses is listed. The health professionals’ awareness regarding existing spontaneous reporting programs is highlighted. Future prospects of pharmacovigilance are discussed. Results: Though beneficial, spontaneous reporting programs encounter several limitations and difficulties in diagnosing adverse drug reaction. Under-reporting and bias are major challenges. Online signal detection tools and innovative methods are needed to strengthen the spontaneous reporting programs. We provide the various issues to be considered while depending on spontaneous reporting programs as a method of post marketing surveillance. Conclusion: To strengthen the spontaneous reporting programs as an effective post marketing surveillance method, more awareness among health professionals and innovative strategies is needed. Integrating pharmacogenetic data can be a potential aspect of future pharmacovigilance. Plain language summary Monitoring adverse effects of marketed medicines through reporting by healthcare professionals and its challenges and way forward Introduction: This article highlights the importance of safety monitoring of medicines after they are launched in the market, mainly through reporting by healthcare professionals. We also highlight the strengths and weaknesses, and provide an insight on the future prospects of pharmacovigilance systems. Methods: Various literature related to the topic were reviewed and the relevant ones highlighting the strengths and weaknesses are summarized. A balance of information on strengths and weaknesses is listed. Health professionals’ awareness regarding existing programs on reporting safety of medicines is highlighted. Results: Though beneficial, reporting of adverse effects by healthcare professionals who deal with patient lacks clarity in diagnosing the adverse effects. Under-reporting and bias are the major challenges. Online software is needed to strengthen reporting by healthcare professionals. We list the various issues to be considered while depending on healthcare professionals’ reporting of adverse effects as a method of post marketing surveillance. Conclusion: To strengthen medicine safety monitoring and reporting by healthcare professionals, more awareness among health professionals and innovative strategies are needed. Integrating the genetic data of patients can be beneficial in predicting adverse effects, therefore avoiding them and enhancing safe prescribing and dispensing by healthcare professionals.

Gaucher disease: Lived experience of patients in the context of a French national patient therapeutic education program

2015 ◽  
Vol 114 (2) ◽  
pp. S28-S29
Author(s):  
Fabrice Camou ◽  
Arnaud Alessandrin ◽  
Eva Toussaint ◽  
Fabienne Eyquard ◽  
Martine Bonnouvrier ◽  
...  
Keyword(s):  
Lived Experience ◽  
Education Program ◽  
Gaucher Disease ◽  
Therapeutic Education ◽  
National Patient ◽  
Patient Therapeutic Education

scholarly journals Adverse Cardiovascular Effects of Anti-COVID-19 Drugs

2021 ◽  
Vol 12 ◽  
Author(s):  
Dongling Liu ◽  
Xiang Zeng ◽  
Zufeng Ding ◽  
Fenghua Lv ◽  
Jawahar L. Mehta ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adverse Effects ◽  
Myocardial Injury ◽  
Cardiovascular Effects ◽  
Cardiovascular Complications ◽  
Therapeutic Interventions ◽  
Risk Of Death ◽  
Cardiovascular Comorbidities ◽  
Global Pandemic ◽  
Acute Myocardial Injury

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 infection is the cause of the ongoing global pandemic. Mortality from COVID-19 infection is particularly high in patients with cardiovascular diseases. In addition, COVID-19 patients with preexisting cardiovascular comorbidities have a higher risk of death. Main cardiovascular complications of COVID-19 are myocardial infarction, myocarditis, acute myocardial injury, arrhythmias, heart failure, stroke, and venous thromboembolism. Therapeutic interventions in terms of drugs for COVID-19 have many cardiac adverse effects. Here, we review the relative therapeutic efficacy and adverse effects of anti-COVID-19 drugs.

scholarly journals Illicit drugs and their impact on cardiovascular pathology

2015 ◽  
Vol 53 (3) ◽  
pp. 218-225 ◽  
Author(s):  
Elisabeta Bădilă ◽  
Mihaela Hostiuc ◽  
Emma Weiss ◽  
Daniela Bartoş
Keyword(s):  
Adverse Effects ◽  
Emergency Departments ◽  
Illicit Drugs ◽  
Cardiovascular Effects ◽  
Therapeutic Management ◽  
Cardiovascular Pathology ◽  
The Past

Abstract The use of illicit drugs has dramatically increased during the past years. Consequently, the number of presentations at the emergency departments due to the adverse effects of the illicit drugs has also increased. This review discusses the cardiovascular effects of cocaine, opiates and opioids, cannabinoids, amphetamines, methamphetamines and hallucinogens as we consider that it is essential for a clinician to be aware of them and understand their mechanisms in order to optimize the therapeutic management.

scholarly journals A patient therapeutic education for hypertensive patients: The Italian agency of drugs (AIFA) final report

2013 ◽  
Vol 16 (3) ◽  
pp. A291
Author(s):  
D. Scala ◽  
M. D'Avino ◽  
E. Menditto ◽  
G. Caruso ◽  
L. De Luca ◽  
...  
Keyword(s):  
Therapeutic Education ◽  
Final Report ◽  
Hypertensive Patients ◽  
Patient Therapeutic Education
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