An in vitro study on hexavalent chromium [Cr(VI)] remediation using iron oxide nanoparticles based beads

2020 ◽  
Vol 14 ◽  
pp. 100333
Author(s):  
S Sathya ◽  
V Ragul ◽  
Vishnu Priya Veeraraghavan ◽  
Lalita Singh ◽  
M I Niyas Ahamed
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hexavalent Chromium ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oxide Nanoparticles

scholarly journals Comparative In Vitro Study on Magnetic Iron Oxide Nanoparticles for MRI Tracking of Adipose Tissue-Derived Progenitor Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108055 ◽  
Author(s):  
Annika Kasten ◽  
Cordula Grüttner ◽  
Jens-Peter Kühn ◽  
Rainer Bader ◽  
Juliane Pasold ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Iron Oxide ◽  
Progenitor Cells ◽  
Iron Oxide Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

scholarly journals Doxorubicin-Conjugated Iron Oxide Nanoparticles Synthesized by Laser Pyrolysis: In Vitro Study on Human Breast Cancer Cells

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2799
Author(s):  
Iulia Ioana Lungu ◽  
Simona Nistorescu ◽  
Mădălina Andreea Badea ◽  
Andreea-Mihaela Petre ◽  
Ana-Maria Udrea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
In Vitro Study ◽  
Oxide Nanoparticles ◽  
Laser Pyrolysis ◽  
Biological Studies

Even today, breast cancer remains a global public problem, with a high mortality rate among women. Nanoparticle (NP) based systems are developed to enhance drug delivery, reducing the toxic effect of medicine molecules. By using iron oxide nanoparticles for cancer treatment, several advantages were highlighted: the ability to target specific locations derived from their magnetic properties and reduced side effects. The aim of this study was to examine on breast cancer cell line the anticancer potential of γ-Fe2O3 NPs loaded with doxorubicin (DOX) and stabilized with carboxymethylcellulose sodium (CMCNa). The γ-Fe2O3 NPs were synthesized by laser pyrolysis technique and their nanometric size and crystallinity were confirmed by X-ray diffraction and transmission electron microscopy. The loading efficiency was estimated by using absorption and fluorescence spectroscopy. The DOX conjugated//CMCNa coated γ-Fe2O3 NPs proved through the biological studies to have a good anticancer effect through the inhibition of tumoral cell proliferation, disruption of the cellular membrane, induction of cell death and reduced effects on normal breast cells. Our data showed that DOX cytotoxicity increases significantly when conjugated with ɣ-Fe2O3 and ɣ-Fe2O3_CMCNa, a 50% reduction of cancer cell viability was obtained with a concentration around 0.1 µg/mL.

scholarly journals Low Blue Dose Photodynamic Therapy with Porphyrin-Iron Oxide Nanoparticles Complexes: In Vitro Study on Human Melanoma Cells

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2130
Author(s):  
Simona Nistorescu ◽  
Ana-Maria Udrea ◽  
Madalina Andreea Badea ◽  
Iulia Lungu ◽  
Mihai Boni ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Iron Oxide ◽  
Singlet Oxygen ◽  
Iron Oxide Nanoparticles ◽  
Light Exposure ◽  
In Vitro Study ◽  
Melanoma Cells ◽  
Oxide Nanoparticles ◽  
Biological Tests

The purpose of this study was to investigate the effectiveness in photodynamic therapy of iron oxide nanoparticles (γ-Fe2O3 NPs), synthesized by laser pyrolysis technique, functionalized with 5,10,15,20-(Tetra-4-sulfonatophenyl) porphyrin tetraammonium (TPPS) on human cutaneous melanoma cells, after only 1 min blue light exposure. The efficiency of porphyrin loading on the iron oxide nanocarriers was estimated by using absorption and FTIR spectroscopy. The singlet oxygen yield was determined via transient characteristics of singlet oxygen phosphorescence at 1270 nm both for porphyrin functionalized nanoparticles and rose bengal used as standard. The irradiation was performed with a LED (405 nm, 1 mW/cm2) for 1 min after melanoma cells were treated with TPPS functionalized iron oxide nanoparticles (γ-Fe2O3 NPs_TPPS) and incubated for 24 h. Biological tests revealed a high anticancer effect of γ-Fe2O3 NPs_TPPS complexes indi-cated by the inhibition of tumor cell proliferation, reduction of cell adhesion, and induction of cell death through ROS generated by TPPS under light exposure. The biological assays were combined with the pharmacokinetic prediction of the porphyrin.

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