Magnetic iron oxide nanoparticles mediated gene therapy for breast cancer — An In Vitro study

2006 ◽  
Vol 26 (6) ◽  
pp. 728-730 ◽  
Author(s):  
Weizhong Wei ◽  
Chunfang Xu ◽  
Hua Wu
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

scholarly journals Comparative In Vitro Study on Magnetic Iron Oxide Nanoparticles for MRI Tracking of Adipose Tissue-Derived Progenitor Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108055 ◽  
Author(s):  
Annika Kasten ◽  
Cordula Grüttner ◽  
Jens-Peter Kühn ◽  
Rainer Bader ◽  
Juliane Pasold ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Iron Oxide ◽  
Progenitor Cells ◽  
Iron Oxide Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

LHRH-conjugated Magnetic Iron Oxide Nanoparticles for Detection of Breast Cancer Metastases

2006 ◽  
Vol 99 (2) ◽  
pp. 163-176 ◽  
Author(s):  
Carola Leuschner ◽  
Challa SSR Kumar ◽  
William Hansel ◽  
Wole Soboyejo ◽  
Jikou Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Breast Cancer Metastases ◽  
Cancer Metastases

scholarly journals Doxorubicin-Conjugated Iron Oxide Nanoparticles Synthesized by Laser Pyrolysis: In Vitro Study on Human Breast Cancer Cells

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2799
Author(s):  
Iulia Ioana Lungu ◽  
Simona Nistorescu ◽  
Mădălina Andreea Badea ◽  
Andreea-Mihaela Petre ◽  
Ana-Maria Udrea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
In Vitro Study ◽  
Oxide Nanoparticles ◽  
Laser Pyrolysis ◽  
Biological Studies

Even today, breast cancer remains a global public problem, with a high mortality rate among women. Nanoparticle (NP) based systems are developed to enhance drug delivery, reducing the toxic effect of medicine molecules. By using iron oxide nanoparticles for cancer treatment, several advantages were highlighted: the ability to target specific locations derived from their magnetic properties and reduced side effects. The aim of this study was to examine on breast cancer cell line the anticancer potential of γ-Fe2O3 NPs loaded with doxorubicin (DOX) and stabilized with carboxymethylcellulose sodium (CMCNa). The γ-Fe2O3 NPs were synthesized by laser pyrolysis technique and their nanometric size and crystallinity were confirmed by X-ray diffraction and transmission electron microscopy. The loading efficiency was estimated by using absorption and fluorescence spectroscopy. The DOX conjugated//CMCNa coated γ-Fe2O3 NPs proved through the biological studies to have a good anticancer effect through the inhibition of tumoral cell proliferation, disruption of the cellular membrane, induction of cell death and reduced effects on normal breast cells. Our data showed that DOX cytotoxicity increases significantly when conjugated with ɣ-Fe2O3 and ɣ-Fe2O3_CMCNa, a 50% reduction of cancer cell viability was obtained with a concentration around 0.1 µg/mL.

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