Relationship between reactive oxygen species and water-soluble organic compounds: Time-resolved benzene carboxylic acids measurement in the coastal area during the KORUS-AQ campaign

2017 ◽  
Vol 231 ◽  
pp. 1-12 ◽  
Author(s):  
Min-Suk Bae ◽  
James J. Schauer ◽  
Taehyoung Lee ◽  
Ju-Hee Jeong ◽  
Yoo-Keun Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Carboxylic Acids ◽  
Organic Compounds ◽  
Coastal Area ◽  
Reactive Oxygen ◽  
Water Soluble ◽  
Oxygen Species ◽  
Time Resolved

Antioxidant Activity and Toxicity of Fullerenols with Different Number of Hydroxyl Substituents

2018 ◽  
Author(s):  
Ekaterina Kovel ◽  
Anna Sachkova ◽  
Natalia Vnukova ◽  
Grigoriy Churilov ◽  
Elena Knyazeva ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Antioxidant Activity ◽  
Biological Effects ◽  
Reactive Oxygen ◽  
Water Soluble ◽  
Oxygen Species ◽  
Allotropic Form ◽  
Oxygen Groups ◽  
Pharmaceutical Agents ◽  
Derivatives Of

Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, specific allotropic form of carbon, bioactive compounds and perspective pharmaceutical agents. We studied biological effects of a series of fullerenols. Antioxidant activity and toxicity of the fullerenols were compared using bioluminescence assays (cellular and enzymatic); a content of Reactive Oxygen Species in fullerenol solutions was determined using chemiluminescence luminol method. Two groups of fullerenols with different number of hydroxyl substituents were under investigation: (I) С60Оy(OH)x, С60,70Оy(OH)x, where х+у=24–28 and (II) С60,70Оy(OH)x, Fe0,5С60Оy(OH)x, where х+у=40–42. Toxicity of the fullerenols was evaluated using effective concentrations ЕС50. Fullerenol’ antioxidant activity was investigated in model solutions of organic toxicant of oxidative type, 1,4-benzoquinone. Detoxification coefficients were calculated to analyze and compare the antioxidant activity. Higher toxicity and lower antioxidant activity were demonstrated in the solutions of fullerenols with higher number of the oxygen substituents (х+у=40–42). The differences were concerned with fullerenol’ ability to disturb Reactive Oxygen Species balance in aqueous solutions. Toxic effect of the prospective endohedral metal-fullerenol with gadolinium atom involved, Gd@C82Oy(OH)x, where х+у=40–42, was evaluated and explained by a high number of oxygen groups

scholarly journals A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species

2010 ◽  
Vol 128 (10) ◽  
pp. 2481-2494 ◽  
Author(s):  
Rajasubramaniam Shanmugam ◽  
Praveen Kusumanchi ◽  
Hitesh Appaiah ◽  
Liang Cheng ◽  
Peter Crooks ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Tumor Growth ◽  
Reactive Oxygen ◽  
Water Soluble ◽  
Oxygen Species

scholarly journals Reactive oxygen species associated with water-soluble PM<sub>2.5</sub> in the southeastern United States: spatiotemporal trends and source apportionment

2014 ◽  
Vol 14 (23) ◽  
pp. 12915-12930 ◽  
Author(s):  
V. Verma ◽  
T. Fang ◽  
H. Guo ◽  
L. King ◽  
J. T. Bates ◽  
...  
Keyword(s):  
United States ◽  
Reactive Oxygen Species ◽  
Source Apportionment ◽  
Biomass Burning ◽  
Southeastern United States ◽  
Reactive Oxygen ◽  
Water Soluble ◽  
Ros Generation ◽  
Vehicular Emissions ◽  
Oxygen Species

Abstract. We assess the potential of the water-soluble fraction of atmospheric fine aerosols in the southeastern United States to generate reactive oxygen species (ROS) and identify major ROS-associated emission sources. ROS-generation potential of particles was quantified by the dithiothreitol (DTT) assay and involved analysis of fine particulate matter (PM) extracted from high-volume quartz filters (23 h integrated samples) collected at various sites in different environmental settings in the southeast, including three urban-Atlanta sites, in addition to a rural site. Paired sampling was conducted with one fixed site in Atlanta (Jefferson Street), representative of the urban environment, with the others rotating among different sites, for ~250 days between June 2012 and September 2013 (N=483). A simple linear regression between the DTT activity and aerosol chemical components revealed strong associations between PM ROS-generation potential and secondary organic aerosol (WSOC – water-soluble organic carbon) in summer, and biomass burning markers in winter. Redox-active metals were also somewhat correlated with the DTT activity, but mostly at urban and roadside sites. Positive matrix factorization (PMF) was applied to apportion the relative contribution of various sources to the ROS-generation potential of water-soluble PM2.5 in urban Atlanta. PMF showed that vehicular emissions contribute uniformly throughout the year (12–25%), while secondary oxidation processes dominated the DTT activity in summer (46%) and biomass burning in winter (47%). Road dust was significant only during drier periods (~12% in summer and fall). Source apportionment by chemical mass balance (CMB) was reasonably consistent with PMF, but with higher contribution from vehicular emissions (32%). Given the spatially large data set of PM sampled over an extended period, the study reconciles the results from previous work that showed only region- or season-specific aerosol components or sources contributing to PM ROS activity, possibly due to smaller sample sizes. The ubiquitous nature of the major sources of PM-associated ROS suggests widespread population exposures to aerosol components that have the ability to catalyze the production of oxidants in vivo.

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