scholarly journals Fine particulate matter air pollution and blood pressure: The modifying role of psychosocial stress

2014 ◽  
Vol 133 ◽  
pp. 195-203 ◽  
Author(s):  
Margaret T. Hicken ◽  
J. Timothy Dvonch ◽  
Amy J. Schulz ◽  
Graciela Mentz ◽  
Paul Max
2014 ◽  
Vol 2014 (1) ◽  
pp. 2177
Author(s):  
Margaret Hicken* ◽  
J. Timothy Dvonch ◽  
Amy J. Schulz ◽  
Graciela Mentz ◽  
Paul Max

Hypertension ◽  
2021 ◽  
Vol 77 (3) ◽  
pp. 813-822
Author(s):  
Sadeer G. Al-Kindi ◽  
Robert D. Brook ◽  
Udayan Bhatt ◽  
Michael Brauer ◽  
William C. Cushman ◽  
...  

Fine particulate matter <2.5 µm (PM 2.5 ) air pollution is implicated in global mortality, especially from cardiovascular causes. A large body of evidence suggests a link between PM 2.5 and elevation in blood pressure (BP), with the latter implicated as a potential mediator of cardiovascular events. We sought to determine if the outcomes of intensive BP lowering (systolic BP <120 mm Hg) on cardiovascular events are modified by PM 2.5 exposure in the SPRINT (Systolic BP Intervention Trial). We linked annual PM 2.5 exposure estimates derived from an integrated model to subjects participating in SPRINT. We evaluated the effect of intensive BP lowering by PM 2.5 exposure on the primary outcome in SPRINT using cox-proportional hazard models. A total of 9286 participants were linked to PM 2.5 levels (mean age 68±9 years). Intensive BP-lowering decreased risk of the primary outcome more among patients exposed to higher PM 2.5 ( P interaction =0.047). The estimate for lowering of primary outcome was numerically lower in the highest than in the lower quintiles. The benefits of intensive BP-lowering were larger among patients chronically exposed to PM 2.5 levels above US National Ambient Air Quality Standards of 12 µg/m 3 (hazard ratio, 0.47 [95% CI, 0.29–0.74]) compared with those living in cleaner locations (hazard ratio, 0.81 [95% CI, 0.68–0.97]), P interaction =0.037. This exploratory nonprespecified post hoc analysis of SPRINT suggests that the benefits of intensive BP lowering on the primary outcome was greater in patients exposed to higher PM 2.5 , suggesting that the magnitude of benefit may depend upon the magnitude of antecedent PM 2.5 exposure.


2021 ◽  
Author(s):  
Bahabaike Jiangtulu ◽  
Changxin Lan ◽  
Junxi Chen ◽  
Bin Wang ◽  
Tao Xue

Abstract Background: Long-term exposure to fine particulate matter (PM2.5 or FPM) may cause adverse effects on cardiovascular diseases. However, evidence that whether improved air quality can decrease blood pressure (BP) in humans is still needed from a large population study. Methods: Our study aimed to investigate the association of population ambient PM2.5 exposure with the blood pressure (BP) changes in China with implementing the Action Plan on Air Pollution Prevention and Control. A total of14,080 participants who had at least two valid visits were adopted from the China Health and Retirement Longitudinal Survey (CHARLS) during 2011–2015. Their long-term PM2.5 exposure was assessed at the geographical level of a regular 0.1° × 0.1° grid over China. A mixed-effects regression model was used to assess their associations. The robustness and homogeneity of the association were tested via sensitivity analyses. Results: The results revealed that each reduction of 10 µg/m3 in the 1 year-mean PM2.5 concentration (FPM1Y) was associated with a decrease of 1.24 (95% confidence interval [CI]: 0.84–1.64) mmHg of systolic BP (SBP) and 0.50 (95% CI: 0.25–0.75) mmHg of diastolic BP (DBP), respectively. A robust association was observed between the long-term reduction of PM2.5 and decreased BP in the middle-aged and elderly population in China. These findings were further confirmed by a non-linear regression model. Conclusions: We concluded that air pollution control for PM2.5 can obviously promote vascular health. Our study provided robust scientific support for making the air pollution control policies.


Author(s):  
Cavin K. Ward‐Caviness, ◽  
Mahdieh Danesh Yazdi, ◽  
Joshua Moyer, ◽  
Anne M. Weaver, ◽  
Wayne E. Cascio, ◽  
...  

Background Long‐term air pollution exposure is a significant risk factor for inpatient hospital admissions in the general population. However, we lack information on whether long‐term air pollution exposure is a risk factor for hospital readmissions, particularly in individuals with elevated readmission rates. Methods and Results We determined the number of readmissions and total hospital visits (outpatient visits+emergency room visits+inpatient admissions) for 20 920 individuals with heart failure. We used quasi‐Poisson regression models to associate annual average fine particulate matter at the date of heart failure diagnosis with the number of hospital visits and 30‐day readmissions. We used inverse probability weights to balance the distribution of confounders and adjust for the competing risk of death. Models were adjusted for age, race, sex, smoking status, urbanicity, year of diagnosis, short‐term fine particulate matter exposure, comorbid disease, and socioeconomic status. A 1‐µg/m 3 increase in fine particulate matter was associated with a 9.31% increase (95% CI, 7.85%–10.8%) in total hospital visits, a 4.35% increase (95% CI, 1.12%–7.68%) in inpatient admissions, and a 14.2% increase (95% CI, 8.41%–20.2%) in 30‐day readmissions. Associations were robust to different modeling approaches. Conclusions These results highlight the potential for air pollution to play a role in hospital use, particularly hospital visits and readmissions. Given the elevated frequency of hospitalizations and readmissions among patients with heart failure, these results also represent an important insight into modifiable environmental risk factors that may improve outcomes and reduce hospital use among patients with heart failure.


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