scholarly journals Effect of ultrasound on the extraction of ellagic acid and hydrolysis of ellagitannins from pomegranate husk

2021 ◽  
pp. 102063
Author(s):  
Diana B. Muñiz-Márquez ◽  
Jorge E. Wong-Paz ◽  
Pedro Aguilar-Zárate ◽  
Leonardo Sepúlveda ◽  
Juan Buenrostro-Figueroa ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Pomegranate Husk ◽  
Hydrolysis Of

Optimization of Ellagic Acid Purification from Pomegranate Husk by Antisolvent Recrystallization

2018 ◽  
Vol 41 (6) ◽  
pp. 1188-1198 ◽  
Author(s):  
Li Wang ◽  
Bolin Lian ◽  
Weiwei Wu ◽  
Yiping Deng ◽  
Yanjie Liu ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Pomegranate Husk

Solid state fermentation of pomegranate husk: Recovery of ellagic acid by SEC and identification of ellagitannins by HPLC/ESI/MS

2018 ◽  
Vol 22 ◽  
pp. 99-104 ◽  
Author(s):  
Leonardo Sepúlveda ◽  
Jorge E. Wong-Paz ◽  
Juan Buenrostro-Figueroa ◽  
Juan A. Ascacio-Valdés ◽  
Antonio Aguilera-Carbó ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Fermentation ◽  
Ellagic Acid ◽  
Esi Ms ◽  
Pomegranate Husk

scholarly journals High or Low Temperature Extraction, Which Is More Conducive to Triphala Aginst Chronic Pharyngitis?

2021 ◽  
Author(s):  
fei Ran ◽  
xue Han ◽  
xuan Deng ◽  
Zhenfeng Wu ◽  
Hanzhou Huang ◽  
...  
Keyword(s):  
High Temperature ◽  
Low Temperature ◽  
Gallic Acid ◽  
Ellagic Acid ◽  
Radical Scavenging ◽  
Network Pharmacology ◽  
Active Ingredients ◽  
Epicatechin Gallate ◽  
Chebulic Acid ◽  
Hydrolysis Of

Abstract BackgroundTriphala is a world famous herbal formula, its therapeutic effect on chronic pharyngitis has been confirmed in the majority of patients in China. However, the effects of current industrial extraction methods on its anti chronic pharyngitis components and activities are still unclear Methods:The network pharmacology was used to analyze the material basis, targets and pathways of Triphala for chronic pharyngitis. HPLC were used to compare the fingerprint profile and content of components between the two extracts. The antioxidant and anti chronic pharyngitis activities of the two extracts were compared by DPPH assay and ammonia induced chronic pharyngitis model in rats. Results:The network pharmacology results showed that the active ingredients of Triphala for chronic pharyngitis are epigallocat echin 3 gallate catechin , epicatechin , epicatechin gallate , g allocatechin , quercetin luteolin leucodelphinidin and other flavonoids, phenolic acids such as gallic acid and ellagic acid, alkaloids such as ellipticine , cheilanthifoline, and hydrolyzed tannins such as corilagin and chebulic acid . The high temperature reflux extract and the low temperature decompressing inner ebullition extract have extremely significant differences in the fingerprint profile. Among them, the content of 8 active ingredients of gallic acid, ellagic acid, chebulic acid , catechin, epicatechin, corilagin, quercetin, and epicatechin gallate in the reflux extract is 1.1 to 5.3 times as much as decompressing inner ebullition extract. The free radical scavenging ability of reflux extract is significantly stronger than that of decompression extract (p<0.01), and it has a repairing effect on pharyngeal mucosal damage (reducing keratinization or hyperplasia of mucosal epithelium, reducing inflammatory cell infiltration and bleeding), and reducing IL 1β (P 0.05), IL 6 (p 0.05), TNF α overexpression ability is stronger than the decompressing inner ebullition extract. Conclusions:gallic acid, ellagic acid, chebulic acid , catechin, epicatechin, corilagin and epicatechin gallate are the basic aglycones or oligomers of tannin. and high temperature reflux extraction can significantly promote temperature reflux extraction can significantly promote tthe occurrence of the he occurrence of the hydrolysis of tannins significantly increases the content of hydrolysis of tannins significantly increases the content of these components, and the these components, and the antianti--chronic pharyngitis activity is enhanced. chronic pharyngitis activity is enhanced. It is suggested that high temperature It is suggested that high temperature reflux extraction should be used in the treatment of chronic phreflux extraction should be used in the treatment of chronic pharyngitis.aryngitis.

scholarly journals Optimization of Gallic Acid Production from Terminalia Chebula byAspergillus niger

2007 ◽  
Vol 4 (2) ◽  
pp. 287-293 ◽  
Author(s):  
N. Lokeswari ◽  
K. Jaya Raju
Keyword(s):  
Aspergillus Niger ◽  
Gallic Acid ◽  
Ellagic Acid ◽  
Condensed Tannin ◽  
Extraction Procedure ◽  
Terminalia Chebula ◽  
Optimal Conditions ◽  
Plant Phenolics ◽  
Simple Extraction ◽  
Hydrolysis Of

A method for producing gallic acid by microbiological hydrolysis of the tannins of myrobalan seed powder is described in the present work. Hydrolysis of gallotannins of the substrate to gallic acid byAspergillus nigerMTCC 282 was studied. A simple extraction procedure is used. Fungal mycelia pre-induced with 5 g/L gallotannin was used as inoculums. Optimal conditions of production were determined using various parameters including gallotannin concentration, nutritional source and metal ions are determined. Gallotannin is hydrolyzed with acid, and gallic acid in the hydrolyses is then assayed using rhodanine. This method is very specific: no interferences from other plant phenolics, including ellagic acid and condensed tannin, have been observed. The yield of gallic acid with respect to gallotannins present in the substrate is estimated. Yields of gallic acid are about 74% with respect to gallotannin concentration, which suggests that this method is exploitable industrially for the manufacturing trimethoprim drug.

scholarly journals Ellagitannins and Oligomeric Proanthocyanidins of Three Polygonaceous Plants

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 337
Author(s):  
Yun-Qiu Li ◽  
Masako Kitaoka ◽  
Juri Takayoshi ◽  
Ya-Feng Wang ◽  
Yosuke Matsuo ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Acid Hydrolysis ◽  
Ellagic Acid ◽  
Hydrolyzable Tannin ◽  
Hydrolyzable Tannins ◽  
Oligomeric Proanthocyanidins ◽  
Spectroscopic Examination ◽  
Hydrolysis Of ◽  
Nuclear Magnetic

The aim of this study was to characterize hydrolyzable tannins in Polygonaceous plants, as only a few plants have previously been reported to contain ellagitannins. From Persicaria chinensis, a new hydrolyzable tannin called persicarianin was isolated and characterized to be 3-O-galloyl-4,6-(S)-dehydrohexahydroxydiphenoyl-d-glucose. Interestingly, acid hydrolysis of this compound afforded ellagic acid, despite the absence of a hexahydroxydiphenoyl group. From the rhizome of Polygonum runcinatum var. sinense, a large amount of granatin A, along with minor ellagitannins, helioscpoinin A, davicratinic acids B and C, and a new ellagitannin called polygonanin A, were isolated. Based on 2D nuclear magnetic resonance (NMR) spectroscopic examination, the structure of polygonanin A was determined to be 1,6-(S)-hexahydroxydiphenoyl-2,4-hydroxychebuloyl-β-d-glucopyranose. These are the second and third hydrolyzable tannins isolated from Polygonaceous plants. In addition, oligomeric proanthocyanidins of Persicaria capitatum and P. chinensis were characterized by thiol degradation. These results suggested that some Polygonaceous plants are the source of hydrolyzable tannins not only proanthocyanidins.

scholarly journals Ellagic Acid as a Tool to Limit the Diabetes Burden: Updated Evidence

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1226
Author(s):  
Antonio J. Amor ◽  
Carmen Gómez-Guerrero ◽  
Emilio Ortega ◽  
Aleix Sala-Vila ◽  
Iolanda Lázaro
Keyword(s):  
Clinical Research ◽  
Diabetic Complications ◽  
Ellagic Acid ◽  
Vascular Complications ◽  
Pomegranate Juice ◽  
Glucose Lowering ◽  
Diabetic Vascular Complications ◽  
Anti Inflammatory ◽  
Hydrolysis Of

Oxidative stress contributes not only to the pathogenesis of type 2 diabetes (T2D) but also to diabetic vascular complications. It follows that antioxidants might contribute to limiting the diabetes burden. In this review we focus on ellagic acid (EA), a compound that can be obtained upon intestinal hydrolysis of dietary ellagitannins, a family of polyphenols naturally found in several fruits and seeds. There is increasing research on cardiometabolic effects of ellagitannins, EA, and urolithins (EA metabolites). We updated research conducted on these compounds and (I) glucose metabolism; (II) inflammation, oxidation, and glycation; and (III) diabetic complications. We included studies testing EA in isolation, extracts or preparations enriched in EA, or EA-rich foods (mostly pomegranate juice). Animal research on the topic, entirely conducted in murine models, mostly reported glucose-lowering, antioxidant, anti-inflammatory, and anti-glycation effects, along with prevention of micro- and macrovascular diabetic complications. Clinical research is incipient and mostly involved non-randomized and low-powered studies, which confirmed the antioxidant and anti-inflammatory properties of EA-rich foods, but without conclusive results on glucose control. Overall, EA-related compounds might be potential agents to limit the diabetes burden, but well-designed human randomized controlled trials are needed to fill the existing gap between experimental and clinical research.

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