SU138SHARING OF GENETIC RISK FACTORS BETWEEN DIFFERENT PROXY MEASURES OF ALCOHOL USE DISORDERS AND RISK OF MENTAL HEALTH DISORDERS

Objective The study aims to investigate the risk factors of bad psychosomatic health among students in quarantine during the first wave of the COVID-19 pandemic. Method:The survey was conducted on-line, on a sample of 1,978 respondents in Poland. The study was carried out by the end of the summer semester. The questionnaire was designed in a way which allows for the observation of main risk factors which have impact on the students’ mental health. The variance analysis and the hierarchical regression analysis were used to determine the predictors of mental health. Results:The results indicate that average and high levels of psychosomatic disorders were observed among 61% of respondents. The hierarchical regression analysis has revealed that the main factors influencing the level of mental health disorders were educational burnout, satisfaction with life, strategies for coping with stress and gender. As indicated by the respondents, mental health disorders increase in tandem with educational burnout, the application of emotion-focused coping strategies and the lack of satisfaction with one’s life. Moreover, it was observed that female respondents scored higher on the scale of disorders in comparison to males. Conclusions:The results of research indicate that distance education and negative coping strategies are the main risk factors of mental health disorders among students during the pandemic.

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Alcohol and mental health: Co-occurring alcohol use and mental health disorders

The Handbook of Alcohol Use ◽

10.1016/b978-0-12-816720-5.00023-2 ◽

2021 ◽

pp. 81-106

Author(s):

Raffaella Margherita Milani ◽

Luisa Perrino

Keyword(s):

Mental Health ◽

Alcohol Use ◽

Mental Health Disorders ◽

Health Disorders

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Chromatin architecture in addiction circuitry elucidates biological mechanisms underlying cigarette smoking and alcohol use traits.

10.1101/2021.03.18.436046 ◽

2021 ◽

Author(s):

Nancy Y.A Sey ◽

Benxia Hu ◽

Marina Iskhakova ◽

Huaigu Sun ◽

Neda Shokrian ◽

...

Keyword(s):

Risk Factors ◽

Alcohol Use ◽

Cigarette Smoking ◽

Genetic Risk ◽

Target Genes ◽

Association Studies ◽

Critical Role ◽

Genetic Risk Factors ◽

Genome Wide Association Studies ◽

Risk Genes

Cigarette smoking and alcohol use are among the most prevalent substances used worldwide and account for a substantial proportion of preventable morbidity and mortality, underscoring the public health significance of understanding their etiology. Genome-wide association studies (GWAS) have successfully identified genetic variants associated with cigarette smoking and alcohol use traits. However, the vast majority of risk variants reside in non-coding regions of the genome, and their target genes and neurobiological mechanisms are unknown. Chromosomal conformation mappings can address this knowledge gap by charting the interaction profiles of risk-associated regulatory variants with target genes. To investigate the functional impact of common variants associated with cigarette smoking and alcohol use traits, we applied Hi-C coupled MAGMA (H-MAGMA) built upon cortical and midbrain dopaminergic neuronal Hi-C datasets to GWAS summary statistics of nicotine dependence, cigarettes per day, problematic alcohol use, and drinks per week. The identified risk genes mapped to key pathways associated with cigarette smoking and alcohol use traits, including drug metabolic processes and neuronal apoptosis. Risk genes were highly expressed in cortical glutamatergic, midbrain dopaminergic, GABAergic, and serotonergic neurons, suggesting them as relevant cell types in understanding the mechanisms by which genetic risk factors influence cigarette smoking and alcohol use. Lastly, we identified pleiotropic genes between cigarette smoking and alcohol use traits under the assumption that they may reveal substance-agnostic, shared neurobiological mechanisms of addiction. The number of pleiotropic genes was ~26-fold higher in dopaminergic neurons than in cortical neurons, emphasizing the critical role of ascending dopaminergic pathways in mediating general addiction phenotypes. Collectively, brain region- and neuronal subtype-specific 3D genome architecture refines neurobiological hypotheses for smoking, alcohol, and general addiction phenotypes by linking genetic risk factors to their target genes.

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Predeployment Sleep Duration and Insomnia Symptoms as Risk Factors for New-Onset Mental Health Disorders Following Military Deployment

SLEEP ◽

10.5665/sleep.2798 ◽

2013 ◽

Vol 36 (7) ◽

pp. 1009-1018 ◽

Cited By ~ 135

Author(s):

Philip Gehrman ◽

Amber D. Seelig ◽

Isabel G. Jacobson ◽

Edward J. Boyko ◽

Tomoko I. Hooper ◽

...

Keyword(s):

Mental Health ◽

Risk Factors ◽

Sleep Duration ◽

Mental Health Disorders ◽

Military Deployment ◽

Health Disorders ◽

Insomnia Symptoms ◽

New Onset

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313 The Prevalence and Risk Factors of Mental Health Disorders in a Danish General Population Study of Children 5-7-Years of Age

Pediatric Research ◽

10.1203/00006450-201011001-00313 ◽

2010 ◽

Vol 68 ◽

pp. 161-161

Author(s):

H Elberling ◽

A Linneberg ◽

A M Skovgaard

Keyword(s):

Mental Health ◽

Risk Factors ◽

General Population ◽

Population Study ◽

Mental Health Disorders ◽

General Population Study ◽

Health Disorders

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Identifying a Need for Mental Health Services Posthospitalization in Adolescent Trauma Patients

Proceedings of IMPRS ◽

10.18060/24631 ◽

2020 ◽

Vol 3 ◽

Author(s):

Alexandra Hochstetler ◽

Ashley Vetor ◽

Jodi Raymond ◽

Hannah Bozell ◽

Teresa Bell

Keyword(s):

Mental Health ◽

Substance Use ◽

Alcohol Use ◽

Mental Health Disorders ◽

Pain Severity ◽

Pain Interference ◽

Prescription Opioid ◽

Opioid Use ◽

Health Disorders ◽

Prescription Opioid Use

Background: Nearly 150,000 children were hospitalized due to an injury in 2018. Hospitalized patients are often prescribed opioids and as a result, one in eight adolescents will continue using opioids twelve months after hospitalization. Predictors of sustained opioid use and future misuse posthospitalization have yet to be studied in adolescents. One of these predictors may be mental health disorders following hospitalization. It is known mental health disorders can lead to substance use disorders if not addressed properly. In this study we examined the associations between injury severity, mental health, and substance use among adolescents. Methods: Patients between 12 to 18 years old admitted for trauma were surveyed upon enrollment, and subsequently at 1, 3, 6, and 12 months posthospitalization. These surveys measured anxiety, depression, posttraumatic stress, prescription and non-prescription drug use, pain severity and pain interference. Results: At enrollment and one-month posthospitalization, higher pain interference was associated with anxiety (p=.003), depression (p<.001), and PTSD (p=.004). Increased pain severity was also associated with higher PTSD (p=.003) However, at three months, pain severity and interference were only associated with PTSD (p=.005, p=.009). Frequent alcohol use and higher PTSD were found to be statistically significant at six and twelve months (p=.02). Regular prescription opioid use was related to higher anxiety (p=.048) and depression (p=.048) only at enrollment and higher PTSD only at one month (p=.034). Prescription opioid use was not associated with pain severity and interference at enrollment but was found significant at one month (p=.016, p=.36). Conclusion: Adolescents who reported higher pain severity and interference also more commonly had mental health disorders such as PTSD, anxiety, and depression. Higher PTSD scores and frequent alcohol use were also related post-injury. Screening for mental health after hospitalization should be further investigated in identifying adolescents who may be at risk for future opioid use disorders.

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"Importance of Mental Health" (Preprint)

10.2196/preprints.23561 ◽

2020 ◽

Author(s):

Salman Muhammad Soomar

Keyword(s):

Mental Health ◽

Risk Factors ◽

Well Being ◽

Mental Health Disorders ◽

Personality Factors ◽

Health Issues ◽

Health It ◽

Handling Stress ◽

Mental Health Issues ◽

Health Disorders

UNSTRUCTURED Health is the state of overall well-being which includes physical, mental, and social wellbeing. Good health is a resource for living everyday life. It is central for functioning properly, handling stress, living a longer and more active life. Physical well-being includes a healthful lifestyle to decrease the risk of disease. Mental health is equally important as physical health, it is integral and important component of health, it provides strength and enhance a person’s ability to complete regular tasks . Differences in socioeconomic and other living conditions can lead to health inequities which can impact on a person’s health especially mental health though this is not the case in every situation, however the risk to an individual’s mental health determine how the person is going to suffer with mental health issues as these risk factors are not only bounded to poor socio-economic class . Violence, rapid social change, stressful work conditions, gender discrimination, social exclusion, physically ill health, sexual abuse, and persistent socio-economic pressures are recognized as risk factors for poor mental health. Moreover, there are some personality factors and genetic factors that also make people vulnerable to mental health disorders . Mental health issues alone add a lot in the global burden of disease however it is associated with other diseases and conditions as well. Mental health disorders in different forms and intensities a large number of people in their lifetime which not only impact on their health but it causes economic burden on the person and family as well . Despite a greater population is affected from mental health illness, the estimates produced through research regarding are still underestimated the reasons may be overlapping between psychiatric and neurological disorder and keeping suicide behaviors associated with self-harm a separate category other than mental illness . The major reason of underestimation can be less no reporting for these illness due to stigma associated with it. Stigma is the negative attitude towards the illness which creates discrimination and is the main obstacle in seeking help and care .

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