Persistent negative symptoms in recent-onset psychosis: Relationship to treatment response and psychosocial functioning

2020 ◽  
Vol 34 ◽  
pp. 76-86 ◽  
Author(s):  
Paola Bucci ◽  
Armida Mucci ◽  
Inge Winter van Rossum ◽  
Carmen Aiello ◽  
Celso Arango ◽  
...  
Keyword(s):  
Treatment Response ◽  
Psychosocial Functioning ◽  
Negative Symptoms ◽  
Recent Onset ◽  
Persistent Negative Symptoms

scholarly journals Automatic sensory information processing abnormalities across the illness course of schizophrenia

2011 ◽  
Vol 42 (1) ◽  
pp. 85-97 ◽  
Author(s):  
C. Jahshan ◽  
K. S. Cadenhead ◽  
A. J. Rissling ◽  
K. Kirihara ◽  
D. L. Braff ◽  
...  
Keyword(s):  
At Risk ◽  
Psychosocial Functioning ◽  
Negative Symptoms ◽  
Sensory Information ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
Control Group ◽  
Chronic Patients ◽  
Sensory Discrimination ◽  
Recent Onset

BackgroundDeficits in automatic sensory discrimination, as indexed by a reduction in the mismatch negativity (MMN) and P3a event-related potential amplitudes, are well documented in chronic schizophrenia. However, MMN and P3a have not been sufficiently studied early in the course of psychotic illness. The present study aimed to investigate MMN, P3a and reorienting negativity (RON) across the course of schizophrenia.MethodMMN, P3a, and RON were assessed in 118 subjects across four groups: (1) individuals at risk for psychosis (n=26); (2) recent-onset patients (n=31); (3) chronic patients (n=33); and (4) normal controls (n=28) using a duration-deviant auditory oddball paradigm.ResultsFrontocentral deficits in MMN and P3a were present in all patient groups. The at-risk group's MMN and P3a amplitudes were intermediate to those of the control and recent-onset groups. The recent-onset and chronic patients, but not the at-risk subjects, showed significant RON amplitude reductions, relative to the control group. Associations between MMN, P3a, RON and psychosocial functioning were present in the chronic patients. In the at-risk subjects, P3a and RON deficits were significantly associated with higher levels of negative symptoms.ConclusionsAbnormalities in the automatic processes of sensory discrimination, orienting and reorienting of attention are evident in the early phases of schizophrenia and raise the possibility of progressive worsening across stages of the illness. The finding that MMN and P3a, but not RON, were reduced before psychosis onset supports the continued examination of these components as potential early biomarkers of schizophrenia.

Does Familiality Predispose to both Emergence and Persistence of Psychosis?

1996 ◽  
Vol 168 (5) ◽  
pp. 620-626 ◽  
Author(s):  
Hélène Verdoux ◽  
Jim Van Os ◽  
Pak C. Sham ◽  
Peter B. Jones ◽  
Karyna Gilvarry ◽  
...  
Keyword(s):  
Family History ◽  
Affective Disorder ◽  
Psychotic Disorder ◽  
Affective Disorders ◽  
Negative Symptoms ◽  
Psychotic Disorders ◽  
Recent Onset ◽  
History Of ◽  
Persistent Negative Symptoms

BackgroundIt has been suggested that in schizophrenia an association exists between family history of schizophrenia and poor outcome on the one hand, and family history of affective disorders and good outcome on the other.MethodWe tested for associations between four-year outcome and familial loading for psychotic disorders in a mixed sample of 150 consecutively admitted patients with functional psychosis (schizophrenia, psychotic affective disorders, other psychotic disorders) of recent onset. For each proband, a familial loading score for (i) broadly defined psychotic disorder, (ii) schizophrenia, and (iii) affective disorder was calculated using information on relatives obtained through the Family History Research Diagnostic Criteria method and direct interviews of relatives with the Schedule for Affective Disorders and Schizophrenia.ResultsIn our sample of psychotic patients, familial loading for psychotic disorder predicted persistent negative symptoms over the follow-up period (OR 1.5; 95% CI 1–2.2), especially in schizophrenia, and was also associated with more time hospitalised (P > 0.05), and more social disability at follow-up (P < 0.05). Greater familial loading for schizophrenia predicted a greater likelihood of non-recovery (OR 2.2; 95% CI 1.1–4.4) and a greater likelihood to have had persistent negative symptoms over the follow-up period (OR 1.7; 95% CI 0.9–3.1). No association was found between outcome and familial loading for affective disorder.ConclusionsWe conclude that familial loading may be a continuous risk factor for some dimensions of clinical outcome in the functional psychoses. This suggests that there is a continuum of genetic liability not only to the emergence of psychotic illness, but also the subsequent chronicity of the disorder.

scholarly journals General psychopathology links burden of recent life events and psychotic symptoms in a network approach

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Linda T. Betz ◽  
◽  
Nora Penzel ◽  
Lana Kambeitz-Ilankovic ◽  
Marlene Rosen ◽  
...  
Keyword(s):  
Life Events ◽  
Childhood Trauma ◽  
Negative Symptoms ◽  
Psychotic Symptoms ◽  
Network Approach ◽  
General Psychopathology ◽  
Recent Onset ◽  
Syndrome Scale ◽  
Before And After ◽  
The Individual

AbstractRecent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.

scholarly journals Linking persistent negative symptoms to amygdala–hippocampus structure in first-episode psychosis

2017 ◽  
Vol 7 (8) ◽  
pp. e1195-e1195 ◽  
Author(s):  
C Makowski ◽  
M Bodnar ◽  
J J Shenker ◽  
A K Malla ◽  
R Joober ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

scholarly journals Mobile-Assisted Cognitive Behavioral Therapy for Negative Symptoms: Open Single-Arm Trial With Schizophrenia Patients

10.2196/24406 ◽  
2020 ◽  
Vol 7 (12) ◽  
pp. e24406
Author(s):  
Eric Granholm ◽  
Jason Holden ◽  
Kristen Dwyer ◽  
Tanya Mikhael ◽  
Peter Link ◽  
...  
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Negative Symptoms ◽  
Behavioral Therapy ◽  
Therapy Group ◽  
Controlled Trial ◽  
Psychosocial Interventions ◽  
Cognitive Behavioral ◽  
Unmet Treatment Need ◽  
Attitude Model ◽  
Persistent Negative Symptoms

Background Negative symptoms are an important unmet treatment need for schizophrenia. This study is a preliminary, open, single-arm trial of a novel hybrid intervention called mobile-assisted cognitive behavioral therapy for negative symptoms (mCBTn). Objective The primary aim was to test whether mCBTn was feasible and could reduce severity of the target mechanism, defeatist performance attitudes, which are associated with experiential negative symptoms and poor functioning in schizophrenia. Methods Participants with schizophrenia or schizoaffective disorder (N=31) who met prospective criteria for persistent negative symptoms were enrolled. The blended intervention combines weekly in-person group therapy with a smartphone app called CBT2go. The app extended therapy group skills, including recovery goal setting, thought challenging, scheduling of pleasurable activities and social interactions, and pleasure-savoring interventions to modify defeatist attitudes and improve experiential negative symptoms. Results Retention was excellent (87% at 18 weeks), and severity of defeatist attitudes and experiential negative symptoms declined significantly in the mCBTn intervention with large effect sizes. Conclusions The findings suggest that mCBTn is a feasible and potentially effective treatment for experiential negative symptoms, if confirmed in a larger randomized controlled trial. The findings also provide support for the defeatist attitude model of experiential negative symptoms and suggest that blended technology-supported interventions such as mCBTn can strengthen and shorten intensive psychosocial interventions for schizophrenia. Trial Registration ClinicalTrials.gov NCT03179696; https://clinicaltrials.gov/ct2/show/NCT03179696

scholarly journals T123. PERSISTENT NEGATIVE SYMPTOMS IN FIRST EPISODE PSYCHOSIS: PREVALENCE, PREDICTORS AND PROGNOSIS

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S163-S163 ◽  
Author(s):  
Stephen Austin ◽  
Carsten Hjorthøj ◽  
Ole Mors ◽  
Rikke Gry Secher ◽  
Pia Jeppesen ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Persistent Negative Symptoms

scholarly journals Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis

2019 ◽  
Vol 45 (6) ◽  
pp. 1279-1290 ◽  
Author(s):  
Minji Bang ◽  
Jee In Kang ◽  
Se Joo Kim ◽  
Jin Young Park ◽  
Kyung Ran Kim ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Receptor Gene ◽  
Network Connectivity ◽  
Inverse Correlation ◽  
Brain Network ◽  
Oxytocin Receptor ◽  
Epigenetic Alterations ◽  
Oxytocin Receptor Gene ◽  
Recent Onset ◽  
Brain Network Connectivity

Abstract Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in the oxytocin receptor gene (OXTR) may be a key mechanism involved in social-emotional disturbances of schizophrenia. Here, we investigated OXTR methylation and its association with clinical and brain network connectivity phenotypes of negative symptoms, particularly anhedonia-asociality, in individuals with recent-onset schizophrenia (ROS) and at ultrahigh risk (UHR) for psychosis. Sixty-four ROS (39 women), 46 UHR (19 women), and 98 healthy individuals (52 women) participated in this study. OXTR methylation was quantified using the pyrosequencing method. A subset of participants (16 ROS, 23 UHR, and 33 healthy controls [HCs]) underwent a 5.5-minute resting-state functional magnetic resonance imaging to determine the relationship between OXTR methylation and the striatal-amygdala network functional connectivity (FC) underlying anhedonia-asociality. Both men and women with ROS and UHR showed significantly decreased OXTR methylation compared to HCs. In women with ROS and UHR, decreased OXTR methylation showed a significant correlation with increased anhedonia-asociality. FC of the striatal-amygdala network, positively associated with the severity of anhedonia-asociality, showed an inverse correlation with OXTR methylation. This study suggests that epigenetic alterations of OXTR, which can be detected before the development of full-blown psychosis, confer susceptibility to schizophrenia and play a crucial role in the manifestation of anhedonia-asociality, particularly in women.

scholarly journals The Impact of Posttraumatic Stress Disorder on Clinical Presentation and Psychosocial Treatment Response in Youth with Functional Abdominal Pain Disorders: An Exploratory Study

Children ◽  
2020 ◽  
Vol 7 (6) ◽  
pp. 56
Author(s):  
Sarah Nelson ◽  
Natoshia Cunningham
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Abdominal Pain ◽  
Posttraumatic Stress ◽  
Treatment Response ◽  
Psychosocial Functioning ◽  
Stress Disorder ◽  
Pain Treatment ◽  
Psychosocial Treatment ◽  
Functional Abdominal Pain ◽  
The Impact

Youth with functional abdominal pain disorders (FAPDs) may report high rates of trauma and/or posttraumatic stress disorder (PTSD), which could impact both physical and psychosocial functioning, in addition to psychosocial treatment response. The current study aimed to examine the rates of PTSD in a sample of 89 youth with FAPDs and examine the association between PTSD with physical and psychosocial functioning. The impact of PTSD on psychosocial treatment response in a subsample of youth with FAPDs was also explored. Participants were youth with FAPDs (ages 9–14) enrolled in a larger study examining the effect of a short-term pain and anxiety focused cognitive behavioral therapy (CBT) treatment (Aim to Decrease Anxiety and Pain Treatment (ADAPT)) for youth with FAPDs. Youth were administered a semi-structured diagnostic interview by a trained clinician to confirm the presence of psychological diagnoses, including PTSD. Measures of physical and psychosocial functioning were also completed. Results revealed a high rate of PTSD in youth with FAPDs with 12.4% meeting diagnostic criteria for the disorder. PTSD was associated with several indicators of increased psychosocial impairment and one indicator of physical impairment. Exploratory analyses revealed comorbid PTSD may impact response to a brief CBT intervention targeting pain and anxiety, but more rigorous controlled studies are needed.

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