P.0048 Prevalence of co-morbidities in autistic children and adolescents in five european countries and the united states: a systematic literature review

Abstract Background Because of progress in antiretroviral therapy (ART), fewer people with HIV experience virologic failure with multiclass resistance. We sought to estimate the prevalence of multiclass resistance since the introduction of INSTI-based regimens using a systematic literature review. Methods A systematic literature search using PubMed, Embase, and the Cochrane Library was conducted of articles published since 2008, the year when INSTI-based regimens for treatment-experienced people with HIV became widely used. Bibliographies of existing literature reviews, websites of European and International organizations reporting data on HIV and AIDS, and abstracts presented from 2016–2018 at conferences were searched to identify additional relevant studies. Using predefined criteria, two reviewers independently reviewed studies reporting multiclass (three-class or greater) resistance in persons with HIV infection who are treatment experienced and were either perinatally infected or infected as adults. Studies from Western Europe, Australia, Canada and the United States (US) using any type of resistance definitions and resistance tests were included. Results A total of 441 unique articles were identified, 343 were excluded during level 1 screening and 98 articles were included for full-text review. A total of 34 articles (11 US studies, 3 from Canada, 1 from Australia, and 19 from Western European countries.) met the inclusion criteria and were included in data extraction analysis. Over the past decade, a modest decrease in the prevalence of three-class (NNRTI, NRTI, PI) resistance was observed in studies from the United States and Canada, ranging from 8.3% in 2009 to 6.7% in 2014 (Figure 1). Western European countries and Australia showed similar trends. The prevalence of 4-class resistance (including INSTIs) with virologic failure in the current treatment era is low, less than 2% (Figure 2). Conclusion The prevalence of multiclass resistance has decreased over the past decade, with three-class resistance continuing to decline and four-class resistance rare. Although the population with treatment failure and no viable options for a suppressive regimen is currently small, this group of people with HIV are in urgent need of novel treatment options. Disclosures All authors: No reported disclosures.

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Asian American Older Adults and Social Isolation: A Systematic Literature Review

Innovation in Aging ◽

10.1093/geroni/igaa057.1051 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 328-328

Author(s):

Simona Kwon ◽

Deborah Min ◽

Stella Chong

Keyword(s):

United States ◽

Older Adults ◽

Literature Review ◽

Social Isolation ◽

Asian Americans ◽

Systematic Literature Review ◽

Asian American ◽

Minority Group ◽

The United States ◽

Eligibility Criteria

Abstract Asian Americans are the fastest growing racial and ethnic minority group in the United States, whose population is aging considerably. Previous studies indicate that social isolation and loneliness disproportionately affects older adults and predicts greater physical, mental, and cognitive decline. A systematic literature review using PRISMA guidelines was conducted to address this emerging need to understand the scope of research focused on social isolation and loneliness among the disparity population of older Asian Americans. Four interdisciplinary databases were searched: PubMed, CINAHL, PsycINFO, and AgeLine; search terms included variations on social isolation, loneliness, Asian Americans, and older adults. Articles were reviewed based on six eligibility criteria: (1) research topic relevance, (2) study participants aged >60 years, (3) Asian immigrants as main participants, (4) conducted in the United States, (5) published between 1995-2019, and (6) printed in the English language. The search yielded 799 articles across the four databases and 61 duplicate articles were removed. Abstracts were screened for the 738 remaining studies, 107 of which underwent full-text review. A total of 56 articles met the eligibility criteria. Synthesis of our review indicates that existing research focuses heavily on Chinese and Korean American immigrant communities, despite the heterogeneity of the diverse Asian American population. Studies were largely observational and employed community-based sampling. Critical literature gaps exist surrounding social isolation and loneliness in Asian American older adults, including the lack of studies on South Asian populations. Future studies should prioritize health promotion intervention research and focus on diverse understudied Asian subgroups.

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mHealth Technology Use and Implications in Historically Underserved and Minority Populations in the United States: Systematic Literature Review

JMIR mhealth and uhealth ◽

10.2196/mhealth.8383 ◽

2018 ◽

Vol 6 (6) ◽

pp. e128 ◽

Cited By ~ 66

Author(s):

Charkarra Anderson-Lewis ◽

Gabrielle Darville ◽

Rebeccah Eve Mercado ◽

Savannah Howell ◽

Samantha Di Maggio

Keyword(s):

United States ◽

Literature Review ◽

Systematic Literature Review ◽

Technology Use ◽

The United States ◽

Minority Populations ◽

Mhealth Technology

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The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review

ClinicoEconomics and Outcomes Research ◽

10.2147/ceor.s259338 ◽

2020 ◽

Vol Volume 12 ◽

pp. 481-497

Author(s):

Leona Bessonova ◽

Kristine Ogden ◽

Michael J Doane ◽

Amy K O'Sullivan ◽

Mauricio Tohen

Keyword(s):

United States ◽

Bipolar Disorder ◽

Literature Review ◽

Systematic Literature Review ◽

Economic Burden ◽

The United States

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Prevalence of Fistulizing Crohn’s Disease in the United States: Estimate From a Systematic Literature Review Attempt and Population-Based Database Analysis

Inflammatory Bowel Diseases ◽

10.1093/ibd/izz056 ◽

2019 ◽

Vol 25 (11) ◽

pp. 1773-1779 ◽

Cited By ~ 8

Author(s):

David A Schwartz ◽

Ignacio Tagarro ◽

Mary Carmen Díez ◽

William J Sandborn

Keyword(s):

United States ◽

Health Care ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Literature Review ◽

Systematic Literature Review ◽

The United States ◽

Population Based ◽

Number Of Patients ◽

Reported Data

Abstract Background Fistulas may arise as a relevant complication of Crohn’s disease (CD). Despite their clinical significance and the substantial burden imposed on patients, limited data are available on the epidemiology of fistulizing CD in the United States. Methods A systematic literature review was conducted to identify data published between 1970 and 2017 on the epidemiology of fistulas in patients with CD, with the aim to estimate the number of prevalent cases in the United States. Retrieved titles and abstracts were screened by 2 independent researchers for inclusion criteria (US population-based studies reporting data on the epidemiology of fistulizing CD). To validate the literature-based estimate, data from a US claims database (Truven Health MarketScan database) were analyzed. This database has broad geographic coverage, with health care data for >60 million patients during the period of the analysis. Results The literature search retrieved 7 articles for full-text review, and only 1 met the criteria for inclusion. This study described the cumulative incidence of fistulas in a CD population from Minnesota over 20 years. From the reported data, the estimated number of prevalent cases with fistulizing CD in the United States was ~76,600 in 2017 (~52,900 anal, ~7400 rectovaginal, ~2300 enterocutaneous, and ~14,100 internal). Analysis from the US health care database resulted in an estimated number of ~75,700 patients, confirming the robustness of the original estimate from the literature. Conclusions Based on 2 separate analyses, the estimated number of patients with fistulizing CD in the United States is ~77,000 patients.

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The economic burden of overactive bladder in the United States: A systematic literature review

Neurourology and Urodynamics ◽

10.1002/nau.23477 ◽

2018 ◽

Vol 37 (4) ◽

pp. 1241-1249 ◽

Cited By ~ 16

Author(s):

Lauren C. Powell ◽

Shelagh M. Szabo ◽

David Walker ◽

Katherine Gooch

Keyword(s):

United States ◽

Overactive Bladder ◽

Literature Review ◽

Systematic Literature Review ◽

Economic Burden ◽

The United States

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1200. Healthcare Claims-Based Lyme Disease Case-Finding Algorithms in the United States: A Systematic Literature Review

Open Forum Infectious Diseases ◽

10.1093/ofid/ofab466.1392 ◽

2021 ◽

Vol 8 (Supplement_1) ◽

pp. S691-S692

Author(s):

Young Hee Nam ◽

Sarah J Willis ◽

Aaron Mendelsohn ◽

Susan Forrow ◽

Jeffrey Brown ◽

...

Keyword(s):

United States ◽

Lyme Disease ◽

Literature Review ◽

Systematic Literature Review ◽

Claims Data ◽

The United States ◽

Case Finding ◽

Diagnosis Codes ◽

Disease Case ◽

The Us

Abstract Background Lyme disease (LD) is the fifth most common notifiable disease in the US with 30,000-40,000 LD cases reported annually via public health surveillance. Recent healthcare claims-based studies utilizing case-finding algorithms estimate national LD cases are >10-fold higher than reported by surveillance. The reliability of claims-based data depends on the accuracy of the case-finding algorithms using the information available in the claims primarily generated for the administrative purposes. To assess the true burden of LD, it is imperative to use validated well-performing LD case-finding algorithms (“LD algorithms”). We conducted a systematic literature review to identify LD algorithms based upon healthcare claims data in the US and their respective performance. Methods We searched PubMed and Embase for articles published in English from January 1, 2000 through the most recent date as of February 20, 2021. We selected articles including all of the following search terms: (1) “Lyme disease”; (2) “claim*” or “administrative* data”; and (3) “United States” or “the US*”. We then reviewed the titles, abstracts, and full texts to identify articles describing LD algorithms developed for claims data. Figure 1 shows the flow diagram following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results We found 15 articles meeting the inclusion criteria. Of these, 7 study algorithms used only LD diagnosis codes (ICD-9, 088.81; ICD-10, A69.2 or A69.2x), 4 studies additionally used antibiotic dispensing records, and 4 studies additionally used serologic test order codes (CPT 86617, 86618). Three studies used different algorithms for inpatient and outpatient settings. Only one study (in Tennessee, a low-incidence state for LD) provided validation results for their algorithm, which only used a LD diagnosis code (ICD-9, 088.81), with reported sensitivity=50% and positive predictive value=5%. Conclusion Validation data on the LD algorithms developed for healthcare claims data are limited, and suggest algorithms using only LD diagnosis codes may not perform well. Further validation of high-performance claims-based LD algorithms is critical to inform the true burden of LD overall and within subgroups. Disclosures Bradford D. Gessner, MD, MPH, Pfizer Inc. (Employee) James Stark, PhD, Pfizer Inc. (Employee) Sarah Pugh, PhD, Pfizer Inc. (Employee)

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