P.0282 Evidence for steroid hormone associations with key brain markers of information filtering in healthy women

2021 ◽  
Vol 53 ◽  
pp. S203-S204
Author(s):  
I. Ivek ◽  
C. Borgsted ◽  
S.T. Pedersen ◽  
A.B. Pinborg ◽  
B. Oranje ◽  
...  
Keyword(s):  
Steroid Hormone ◽  
Information Filtering ◽  
Healthy Women

scholarly journals Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An exploratory metabolomics study

2021 ◽  
Vol 17 ◽  
pp. 174480692110418
Author(s):  
Jennifer S Labus ◽  
Emeran A Mayer ◽  
Kjersti Aagaard ◽  
Jean Stains ◽  
Katarzyna Broniowska ◽  
...  
Keyword(s):  
Steroid Hormone ◽  
Sensitivity Analyses ◽  
Plasma Metabolites ◽  
Vaginal Fluid ◽  
Provoked Vestibulodynia ◽  
Steroid Hormone Biosynthesis ◽  
Healthy Women ◽  
Muscle Tenderness ◽  
Hormone Biosynthesis ◽  
The Impact

Provoked vestibulodynia (PVD) is a chronic vulvar pain disorder characterized by hypersensitivity and severe pain with pressure localized to the vulvar vestibule. Knowledge regarding pathophysiological mechanisms contributing to the etiology and production of symptoms in PVD remains incomplete but is considered multifactorial. Using a cross-sectional observational study design, data from untargeted metabolomic profiling of vaginal fluid and plasma in women with PVD and healthy women was combined with pain testing and brain imaging in women with PVD to test the hypotheses that women with PVD compared to healthy women show differences in vaginal and plasma metabolites involved in steroid hormone biosynthesis. Steroid hormone metabolites showing group differences were correlated with vulvar vestibular pain and vaginal muscle tenderness and functional connectivity of brain regions involved in pain processing in women with PVD to provide insight into the functional mechanisms linked to the identified alterations. Sensitivity analyses were also performed to determine the impact of hormonal contraceptive use on the study findings. Women with PVD compared to healthy controls had significant reductions primarily in vaginal fluid concentrations of androgenic, pregnenolone and progestin metabolites involved in steroidogenesis, suggesting localized rather than systemic effects in vagina and vulvar vestibule. The observed reductions in androgenic metabolite levels showed large effect size associations with increased vulvar vestibular pain and vulvar muscle tenderness and decreases in androgenic and progestin metabolites were associated with decreased connectivity strength in primary sensorimotor cortices. Women with PVD showed symptom-associated reductions in vaginal fluid concentrations of metabolites involved in the biosynthesis of steroid hormones previously shown to affect the integrity of vulvar and vaginal tissue and nociceptive processing. Deficiency of certain steroids may be an important mechanism contributing to the pathophysiology of symptoms in PVD may provide potential diagnostic markers that could lead to new targets for therapeutic intervention.

Calcium Reduces Fractures in Healthy Women

2005 ◽  
Vol 38 (2) ◽  
pp. 34
Author(s):  
TIMOTHY F. KIRN
Keyword(s):  
Healthy Women

Menstrual Cycle Modulation of Benzodiazepines Effects in Healthy Women

2009 ◽  
Author(s):  
Shanna Babalonis ◽  
Joshua A. Lile ◽  
Catherine A. Martin ◽  
Thomas H. Kelly
Keyword(s):  
Menstrual Cycle ◽  
Healthy Women

Differences in gene expression of eutopic endometrium from healthy women and endometriosis patients

2016 ◽  
Vol 76 (10) ◽  
Author(s):  
I Beyer ◽  
R van Rensburg ◽  
S Boeddecker ◽  
JS Kruessel ◽  
T Fehm ◽  
...  
Keyword(s):  
Gene Expression ◽  
Eutopic Endometrium ◽  
Healthy Women

STEROID HORMONE METABOLISM IN RESPONSIVE TISSUES IN VITRO

1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S279-S294 ◽  
Author(s):  
Paul Robel
Keyword(s):  
Steroid Hormone ◽  
Physiological Activity ◽  
Physiological State ◽  
Target Cells ◽  
Target Tissue ◽  
Hormone Metabolism ◽  
Metabolizing Enzymes ◽  
Relationship Of

ABSTRACT Of the information available on steroid hormone metabolism in responsive tissues, only that relating hormone metabolism to physiological activity is reviewed, i. e. metabolite activity in isolated in vitro systems, binding of metabolites to target tissue receptors, specific steroid hormone metabolizing enzymes and relationship of hormone metabolism to target organ physiological state. Further, evidence is presented in the androgen field, demonstrating 5α-reduced metabolites, formed inside the target cells, as active compounds. This has led to a consideration of testosterone as a »prehormone«. The possibility that similar events take place in tissues responding to progesterone is discussed. Finally, the role of hormone metabolism in the regulation of hormone availability and/or renewal in target cells is discussed. In this context, reference is made to the potential role of plasma binding proteins and cytosol receptors.

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