Objective of this study was to determine the effect Kigelia africana fruit extract has on blood glucose levels ofdiabetes mice and its phytochemical profile. Mice were induced with diabetes using Alloxan monohydrate90mg/kg. Blood glucose was checked before induction and 72 hours after induction to confirm diabetes. Treatmentinvolved using oral administration of Kigelia fruit extract 1000mg/kg, Kigelia fruit extract 500mg/kg,Glibenclamide 0.25 mg/kg, Kigelia fruit extract 500mg/kg and Glibenclamide 0.25mg/kg and Normal Saline. Theresults showed a greater reduction in blood glucose of mice after treatment with Kigelia extract 1000mg/kgcompared to Kigelia 500mg/kg [(5.3 +/- 0.5mmol/l) vs (6.3+/- 0.6mmol/l), (p= 0.005)]. Further, Glibenclamide0.25mg/kg showed less reduction in blood glucose than Kigelia 1000mg/kg [(7.4+/-0.9mmol/l) vs (5.3 +/- 0.5), (p=0.00)]. The mean blood glucose levels were lower in mice that received Kigelia extract than those that receivedboth Kigelia extract and Glibenclamide [(5.3 +/- 0.5mmol/l) vs (7.8 +/- 0.6 mmol/l), (p=0.00)]. The fruit extracttested positive for Tannins, Saponins, Flavanoids, Alkaloids, Glycosides and Steroids. Findings of this studyindicate that Kigelia africana fruit extract causes reduction in blood glucose of diabetes induced mice and givesbetter results when used alone than in concomitant use with Glibenclamide. The study also indicates that the fruitextract has alkaloids, saponins, steroids, glycosides, tannins and flavonoids.
Insight into multilayered alginate/chitosan microparticles for oral administration of large cranberry fruit extract
