Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in japanese healthy volunteers

2007 ◽  
Vol 22 (7) ◽  
pp. 462-465 ◽  
Author(s):  
Genki ishii ◽  
Akihito Suzuki ◽  
Shingo Oshino ◽  
Hiroaki Shiraishi ◽  
Yoshihiko Matsumoto ◽  
...  
Keyword(s):  
Personality Traits ◽  
Healthy Volunteers ◽  
Healthy Subjects ◽  
Temperament And Character Inventory ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Pcr Rflp ◽  
Character Inventory ◽  
The Relationship

AbstractCatechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. It has been suggested that catecholaminergic neurotransmission is involved in characterization of personality. Previous studies on the association between the COMT Val158Met polymorphism and personality traits in healthy subjects have produced inconsistent results. Therefore, the relationship between this polymorphism and personality was re-examined in 478 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character inventory (TCI), and the COMT genotypes were determined by a PCR-RFLP method. in total, there were no significant differences among the Val/Val, Val/Met, and Met/Met genotypes in seven TCI dimension scores. Similarly, no significant relationship was found between the COMT genotypes and the TCI dimensions when males and females were analyzed separately. The present study thus suggests that the COMT Val158Met polymorphism is not associated with personality traits in Japanese healthy subjects.

Association study between glucocorticoid receptor polymorphisms and personality traits in healthy subjects

2011 ◽  
Vol 26 (S2) ◽  
pp. 809-809
Author(s):  
Y. Matsumoto ◽  
A. Suzuki ◽  
N. Shibuya ◽  
R. Sadahiro ◽  
M. Kamata ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Personality Traits ◽  
Hpa Axis ◽  
Healthy Subjects ◽  
Feedback System ◽  
Dimension Score ◽  
Character Inventory ◽  
Glucocorticoid Receptor Polymorphisms ◽  
Important Regulator

AimsPrevious studies have shown that the function of hypothalamic-pituitary-adrenal (HPA) axis is involved in the characterization of personality traits. Glucocorticoid receptor (GR) is the most important regulator of the HPA axis negative feedback system, and several polymorphisms of the GR gene are associated with altered glucocorticoid sensitivity. In the present study, we examined the associations between the GR polymorphisms and personality traits in healthy subjects.MethodsSubjects were 880 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character Inventory (TCI). Two polymorphisms of the GR gene, i.e., G/C SNP in the intron 2 (BcII polymorphism, rs41423247) and A/G SNP in the exon 9β (9β polymorphism, rs6198), were detected by a real-time PCR and cycling probe technology for SNP typing.ResultsThe genotype distributions were G/G = 614, G/C = 240, and C/C = 26 for the BcII polymorphism, and A/A = 879 and A/G = 1 for the 9β polymorphism, respectively. There were no significant associations between the BcII genotype groups in any TCI dimension score.ConclusionThe present study suggests that these two GR polymorphisms (BcII and 9β polymorphism) are not involved in the characterization of personality traits in healthy subjects.

Relationship Between Leukocyte Telomere Length and Personality Traits in Healthy Subjects

2015 ◽  
Vol 30 (2) ◽  
pp. 291-295 ◽  
Author(s):  
R. Sadahiro ◽  
A. Suzuki ◽  
M. Enokido ◽  
Y. Matsumoto ◽  
N. Shibuya ◽  
...  
Keyword(s):  
Personality Traits ◽  
Telomere Length ◽  
Dna Sequences ◽  
Healthy Subjects ◽  
Single Copy ◽  
Stepwise Multiple Regression ◽  
Leukocyte Telomere Length ◽  
Neo Personality Inventory ◽  
Character Inventory ◽  
The Relationship

AbstractBackground:It has been shown that certain personality traits are related to mortality and disease morbidity, but the biological mechanism linking them remains unclear. Telomeres are tandem repeat DNA sequences located at the ends of chromosomes, and shorter telomere length is a predictor of mortality and late-life disease morbidity. Thus, it is possible that personality traits influence telomere length. In the present study, we examined the relationship of leukocyte telomere length with personality traits in healthy subjects.Subjects and methods:The subjects were 209 unrelated healthy Japanese who were recruited from medical students at 4th–5th grade. Assessment of personality traits was performed by the Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI). Leukocyte relative telomere length was determined by a quantitative real-time PCR method for a ratio of telomere/single copy gene.Results:In the stepwise multiple regression analysis, shorter telomere length was related to lower scores of neuroticism (P < 0.01) and conscientiousness (P < 0.05) of the NEO-PI-R, and lower scores of harm avoidance (P < 0.05) and reward dependence (P < 0.05) of the TCI.Conclusions:The present study suggests that leukocyte telomere length is associated with some personality traits, and this association may be implicated in the relationship between personality traits and mortality.

Temperament and character inventory (TCI) personality profile in metamphetamine abusers: a controlled study

2004 ◽  
Vol 19 (4) ◽  
pp. 193-195 ◽  
Author(s):  
Ladislav Hosák ◽  
Marek Preiss ◽  
Martin Halíř ◽  
Eva Čermáková ◽  
Ladislav Csémy
Keyword(s):  
Healthy Volunteers ◽  
Harm Avoidance ◽  
Controlled Study ◽  
Personality Questionnaire ◽  
Novelty Seeking ◽  
Personality Profile ◽  
Temperament And Character Inventory ◽  
Prevention And Treatment ◽  
Character Inventory ◽  
Self Transcendence

AbstractWe applied the temperament and character inventory (TCI) personality questionnaire in 41 inpatients dependent on metamphetamine, and 35 controls. Novelty seeking, harm avoidance and self-transcendence were significantly higher, and persistence, self-directedness and cooperativeness were significantly lower in the patients than in the healthy volunteers. The detected differences may be important for prevention and treatment.

scholarly journals Personality traits and treatment outcome in obsessive-compulsive disorder

2008 ◽  
Vol 30 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Felipe Corchs ◽  
Fábio Corregiari ◽  
Ygor Arzeno Ferrão ◽  
Tania Takakura ◽  
Maria Eugênia Mathis ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Personality Traits ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Behavioral Therapy ◽  
Temperament And Character Inventory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Scale Scores ◽  
Character Inventory ◽  
Poor Treatment

OBJECTIVE: Comorbidity with personality disorders in obsessive-compulsive patients has been widely reported. About 40% of obsessive-compulsive patients do not respond to first line treatments. Nevertheless, there are no direct comparisons of personality traits between treatment-responsive and non-responsive patients. This study investigates differences in personality traits based on Cloninger's Temperament and Character Inventory scores between two groups of obsessive-compulsive patients classified according to treatment outcome: responders and non-responders. METHOD: Forty-four responsive and forty-five non-responsive obsessive-compulsive patients were selected. Subjects were considered treatment-responsive (responder group) if, after having received treatment with any conventional therapy, they had presented at least a 40% decrease in the initial Yale-Brown Obsessive Compulsive Scale score, had rated "better" or "much better" on the Clinical Global Impressions scale; and had maintained improvement for at least one year. Non-responders were patients who did not achieve at least a 25% reduction in Yale-Brown Obsessive Compulsive Scale scores and had less than minimal improvement on the Clinical Global Impressions scale after having received treatment with at least three selective serotonin reuptake inhibitors (including clomipramine), and at least 20 hours of cognitive behavioral therapy. Personality traits were assessed using Temperament and Character Inventory. RESULTS: Non-responders scored lower in self-directedness and showed a trend to score higher in persistence than responders did. CONCLUSION: This study suggests that personality traits, especially self-directedness, are associated with poor treatment response in obsessive-compulsive patients.

P300 event-related brain potential and personality in depression

2000 ◽  
Vol 15 (6) ◽  
pp. 370-377 ◽  
Author(s):  
M. Hansenne ◽  
W. Pitchot ◽  
E. Pinto ◽  
J Reggers ◽  
P. Papart ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Normal Subjects ◽  
P300 Amplitude ◽  
Temperament And Character Inventory ◽  
Brain Potential ◽  
Depressed Patients ◽  
Character Inventory ◽  
Positive Correlations ◽  
Psychotic Features ◽  
The Relationship

summaryP300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect, suicidal behavior and psychotic features significantly influence P300 amplitude. However, no data are available on the possible influences of the personality of depressed patients on P300. Since personality is related to P300 in normal subjects, the aim of the present study is to investigate the relationship between ERPs (P200, N200, and P300) and the Temperament and Character Inventory (TCI) in 54 depressed patients. The main results of the study concern the absence of major correlations between personality dimensions as assessed by the TCI and ERP parameters among depressed patients. Only weak partial positive correlations relate N200 latency with harm avoidance, and P300 amplitude (Pz) with the self-directedness dimension. N200 amplitude is also negatively correlated to persistence. However, the preliminary nature of the presented results with respect to the weak statistical significance should be underlined.

Interrogating the Relationship Between Schizotypy, the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism, and Neuronal Oscillatory Activity

2018 ◽  
Vol 29 (7) ◽  
pp. 3048-3058 ◽  
Author(s):  
Genevieve Z Steiner ◽  
Francesca M Fernandez ◽  
Madilyn Coles ◽  
Diana Karamacoska ◽  
Emma Barkus ◽  
...  
Keyword(s):  
Oscillatory Activity ◽  
Comt Genotype ◽  
Schizotypal Personality ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Increased Risk ◽  
Eyes Open ◽  
Neurophysiological Mechanisms ◽  
Beta 2 ◽  
The Relationship

Abstract The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. Schizotypy is associated with an increased risk of psychosis, with some studies implicating similar neurobiological mechanisms to schizophrenia. The present study sought to interrogate the link between the COMT Val158Met polymorphism and schizotypy using electroencephalogram (EEG) to identify neurophysiological mechanisms underpinning psychosis risk. Neurotypical (N = 91) adults were genotyped for the COMT Val158Met polymorphism, completed the Schizotypal Personality Questionnaire (SPQ), and had eyes open resting-state EEG recorded for 4 min. SPQ suspiciousness subscale scores were higher for individuals homozygous for Val/Val and Met/Met versus Val/Met genotypes. Delta, theta, alpha-2, beta-1, and beta-2 amplitudes were lower for Val/Val than Met/Met individuals. Lower theta amplitudes were correlated with higher total SPQ scores (P = 0.050), and multiple regression revealed that higher delta, and lower theta and beta-2 amplitudes (but not COMT genotype) best predicted total SPQ scores (P = 0.014). This study demonstrates the importance of COMT genotype in determining trait suspiciousness and EEG oscillatory activity. It also highlights relationships between dopaminergic alterations, EEG and schizotypy that are dissimilar to those observed in schizophrenia.

scholarly journals Temperament and Eating Attitudes in an Adolescent Community Sample: A Brief Report

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Enrica Marzola ◽  
Secondo Fassino ◽  
Federico Amianto ◽  
Giovanni Abbate-Daga
Keyword(s):  
High School Students ◽  
Community Sample ◽  
Eating Attitudes ◽  
Harm Avoidance ◽  
Novelty Seeking ◽  
Temperament And Character Inventory ◽  
School Students ◽  
Food Frequency ◽  
Character Inventory ◽  
The Relationship

Objective. Temperament traits like high harm avoidance (HA) have been proposed as putative risk factors for the development of eating disorders (EDs). We aimed at studying the relationship between temperament and eating attitudes on a large community sample of adolescents. Method. We recruited 992 high school students aged 14–18. In addition to measuring body mass index (BMI), participants were asked to complete the temperament and character inventory and the food frequency questionnaire. Results. Sixty-two percent of the sample reported overeating, 22.8% reported normal eating, and 15.2% reported under eating. Under and normal eaters had higher BMI than that of over eaters. Harm avoidance was found to be significantly higher in those participants with lower eating intakes whilst novelty seeking was found to be higher in over eaters. Conclusion. An interesting association between temperament (high HA) and food approach (under eating) emerged. Longitudinal studies are needed to evaluate whether these traits represent a risk factor for the development of EDs.

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