Childhood adversity as a risk factor for the early onset and chronicity of depression and anxiety disorders

2008 ◽  
Vol 23 ◽  
pp. S32
Author(s):  
J. Angst ◽  
A. Gamma ◽  
V. Ajdacic-Gross ◽  
W. Roessler
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Early Onset ◽  
Childhood Adversity ◽  
Depression And Anxiety

scholarly journals Association of headache with childhood adversity and mental disorder: cross-national study

2009 ◽  
Vol 194 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Sing Lee ◽  
Adley Tsang ◽  
Michael Von Korff ◽  
Ron de Graaf ◽  
Corina Benjet ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Early Onset ◽  
Childhood Adversity ◽  
Self Report ◽  
National Study ◽  
Adult Onset ◽  
Community Studies ◽  
Cross Sectional ◽  
Cross National Study ◽  
Joint Associations

BackgroundCommunity studies about the association of headache with both childhood family adversities and depression/anxiety disorders are limited.AimsTo assess the independent and joint associations of childhood family adversities and early-onset depression and anxiety disorders with risks of adult-onset headache.MethodData were pooled from cross-sectional community surveys conducted in ten Latin and North American, European and Asian countries (n=18 303) by using standardised instruments. Headache and a range of childhood family adversities were assessed by self-report.ResultsThe number of childhood family adversities was associated with adult-onset headache after adjusting for gender, age, country and early-onset depression/anxiety disorder status (for one adversity, hazard ratio (HR)=1.22–1.6; for two adversities, HR=1.19–1.67; for three or more adversities, HR=1.37–1.95). Early and current onset of depression/anxiety disorders were independently associated (HR=1.42–1.89) with adult-onset headache after controlling for number of childhood family adversities.ConclusionsThe findings call for a broad developmental perspective concerning risk factors for development of headache.

Childhood Adversity, Early-Onset Depressive/Anxiety Disorders, and Adult-Onset Asthma

2008 ◽  
Vol 70 (9) ◽  
pp. 1035-1043 ◽  
Author(s):  
Kate M. Scott ◽  
Michael Von Korff ◽  
Jordi Alonso ◽  
Matthias C. Angermeyer ◽  
Corina Benjet ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Early Onset ◽  
Childhood Adversity ◽  
Adult Onset

Effects of an Anxiety-Specific Psychometric Factor on Fear Conditioning and Fear Generalization

2017 ◽  
Vol 225 (3) ◽  
pp. 200-213 ◽  
Author(s):  
Christian Baumann ◽  
Miriam A. Schiele ◽  
Martin J. Herrmann ◽  
Tina B. Lonsdorf ◽  
Peter Zwanzger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Fear Conditioning ◽  
Longitudinal Design ◽  
Principal Component ◽  
Anxiety And Depression ◽  
Specific Factor ◽  
High Anxious ◽  
Two Factors ◽  
Fear Generalization

Abstract. Conditioning and generalization of fear are assumed to play central roles in the pathogenesis of anxiety disorders. Here we investigate the influence of a psychometric anxiety-specific factor on these two processes, thus try to identify a potential risk factor for the development of anxiety disorders. To this end, 126 healthy participants were examined with questionnaires assessing symptoms of anxiety and depression and with a fear conditioning and generalization paradigm. A principal component analysis of the questionnaire data identified two factors representing the constructs anxiety and depression. Variations in fear conditioning and fear generalization were solely associated with the anxiety factor characterized by anxiety sensitivity and agoraphobic cognitions; high-anxious individuals exhibited stronger fear responses (arousal) during conditioning and stronger generalization effects for valence and UCS-expectancy ratings. Thus, the revealed psychometric factor “anxiety” was associated with enhanced fear generalization, an assumed risk factor for anxiety disorders. These results ask for replication with a longitudinal design allowing to examine their predictive validity.

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

2019 ◽  
Author(s):  
Juyoen Hur ◽  
Melissa D. Stockbridge ◽  
Andrew S. Fox ◽  
Alexander J. Shackman
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Executive Control ◽  
Intervention Strategies ◽  
Attentional Biases ◽  
Translational Neuroscience ◽  
Adult Personality ◽  
Fundamental Dimension ◽  
To Come ◽  
Underlying Mechanisms

When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.

A comparison between risk-factor guidance for neonatal early-onset sepsis and Kaiser Permanente sepsis risk calculator in a Greek cohort

2021 ◽  
Vol 155 ◽  
pp. 105331
Author(s):  
Dimitrios Rallis ◽  
Foteini Balomenou ◽  
Konstantina Karantanou ◽  
Kleio Kappatou ◽  
Meropi Tzoufi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Early Onset ◽  
Risk Calculator ◽  
Kaiser Permanente ◽  
Early Onset Sepsis ◽  
Sepsis Risk
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