Treatment of nausea and vomiting associated with cerebellar infarction using the traditional herbal medicines Banhabaekchulcheonma-tang and Oryeong-san: Two case reports (CARE-complaint)

Background: Multiple sclerosis (MS) is a chronic immune-mediated inflammatory disease of the central nervous system that is gradually increasing in prevalence. The etiology of MS remains unknown; however, it is assumed to be caused by a deterioration of autoimmune regulation. Although immunomodulatory agents are a standard treatment option in patients with MS, there is insufficient evidence about their clinical efficacy in symptomatic treatment, and many MS patients resort to complementary and alternative medicine. For this reason, we conducted a scoping review to investigate the current status of the clinical evidence related to traditional East Asian herbal medicine treatment for MS and to inform future research and treatment strategies.Method: A scoping review is an emerging methodology for knowledge synthesis that adopts the Arksey and O'Malley framework. The research question was, “What has been studied about the herbal medicine treatments administered to patients with MS?” Articles published until 2019 were identified in six databases (PubMed, Embase, Cochrane, KoreaMed, NDSL, and OASIS) in March of 2020. Data from the included studies were charted and descriptively analyzed in relation to the study's research questions.Results: Of the 1,445 articles identified, 14 studies were included in this review. Single and serial case reports constituted the majority (42.86%), with 57.14% of studies conducted in China. A total of 20 prescriptions containing 95 herbs were used in the intervention and observational studies. Herbal medicines were effective at improving clinical symptoms of MS and reducing recurrence frequency. The main cause of MS was presumed to be oxidative stress, which enhances inflammation and, consequently, causes neuronal death.Conclusion: Herbal medicines were determined to improve the symptoms of MS and to reduce the frequency of recurrences. This study suggests that herbal medicines are promising and worth pursuing further studies but the state of current evidence is poor. Thus, further, high-quality studies included larger randomized trial are required.

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A Case of Cerebellar Infarction Patient with Vertigo, Nausea, and Vomiting

The Journal of Internal Korean Medicine ◽

10.22246/jikm.2018.39.5.853 ◽

2018 ◽

Vol 39 (5) ◽

pp. 853-862

Author(s):

Chan-young Kim ◽

Eun-sun Jung ◽

Ji-yun Cha ◽

In-chan Seol ◽

Yoon-sik Kim ◽

...

Keyword(s):

Nausea And Vomiting ◽

Cerebellar Infarction

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Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity — a Systematic Review and Meta-Analysis

Frontiers in Oncology ◽

10.3389/fonc.2021.629132 ◽

2021 ◽

Vol 11 ◽

Author(s):

Yuanyuan Chen ◽

Chien-shan Cheng ◽

Hor-Yue Tan ◽

Chi Wing Tam ◽

Ning Wang ◽

...

Keyword(s):

Oral Mucositis ◽

Meta Analysis ◽

Herbal Medicines ◽

Abdominal Distension ◽

Nausea And Vomiting ◽

Sensitivity Analyses ◽

Controlled Trials ◽

Double Blind ◽

Randomized Controlled ◽

Double Blind Design

Purpose: Chemotherapy-induced gastrointestinal (CIGI) toxicity affects the quality of life of patients with colorectal cancer (CRC) and the clinical application of treatment drugs. This review aims to evaluate the efficacy of traditional herbal medicines (HMs) in alleviating symptoms of CIGI toxicity (including nausea and vomiting, anorexia, diarrhea, constipation, oral mucositis, abdominal pain, and abdominal distension), and to explore further individual herb or herbal combinations in alleviating the CIGI toxicity.Methods: Nine electronic databases were screened from 2010 to 2020. Twenty-two randomized controlled trials with a total of 1,995 patients evaluating the complementary efficacy of HMs with chemotherapy compared with chemotherapy-alone were included. Further, sensitivity analyses of orally administered multi-ingredient HM interventions were explored based on the composition of HM interventions.Results: The meta-analysis showed that HM treatment combined with chemotherapy significantly alleviated the overall CIGI toxicity (RR = 0.78 [0.72, 0.84], p < 0.001, I2 = 44%), nausea and vomiting (RR = 0.74 [0.66, 0.82], p < 0.001, I2 = 35%), diarrhea (P = 0.02, RR = 0.64, 95% CI = 0.44–0.93, I2 = 50%), oral mucositis (RR = 0.65 [0.48, 0.88], P = 0.005, I2 = 24%), and abdominal distension (RR = 0.36 [0.18, 0.73], P = 0.004, I2 = 0%). However, no statistically significant effects of HMs were shown in studies with a double-blind design for CIGI toxicity. Based on the ingredients of the HMs, further sensitivity analyses identified five herbs [Glycyrrhiza uralensis Fisch., Atractylodes macrocephala Koidz., Astragalus membranaceus (Fisch.) Bge., Codonopsis pilosula (Franch.) Nannf., and the pericarp of Citrus reticulata Blanco.] that were associated with significant reductions in CIGI toxicity.Conclusion: A statistically significant effect of HMs combined with chemotherapy on alleviating the overall CIGI toxicity, nausea and vomiting, diarrhea, oral mucositis, or abdominal distension is only shown in studies without a double-blind design. Further well-designed, double-blinded, large-scaled randomized controlled trials (RCTs) are warranted to comprehensively evaluate the treatment efficacy. Further clinical research that includes the five herbs with chemotherapy for patients, the safety of the combinations of these herbs, and the potential synergistic effects of these combinations of herbs should be conducted.

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Herbal medicines and pregnancy: A narrative review and anaesthetic considerations

Anaesthesia and Intensive Care ◽

10.1177/0310057x19845786 ◽

2019 ◽

Vol 47 (3) ◽

pp. 226-234 ◽

Cited By ~ 1

Author(s):

Peter CA Kam ◽

Denise WY Barnett ◽

Ian D Douglas

Keyword(s):

Case Reports ◽

Herbal Medicines ◽

Kinetic Studies ◽

Narrative Review ◽

Levels Of Evidence ◽

Level 3 ◽

American Society ◽

American Society Of Anesthesiologists ◽

Based Medicine ◽

Level 2

The use of herbal medicines by pregnant women varies among different countries, ranging from 4.3% in Sweden to 69% in Russia. The aim of this narrative review is to evaluate the benefits and safety of common herbal medicines used during pregnancy. A systematic literature search (from 1995 to February 2018) was performed using a variety of electronic databases. The levels of evidence of the clinical studies were graded using the Oxford Centre for Evidence-Based Medicine levels of evidence guidelines. From the 736 articles retrieved, 69 articles were used for this review. Ginger has been investigated extensively and has been consistently found to decrease nausea and vomiting associated with pregnancy (Level 2). There is insufficient evidence concerning the efficacy of other herbal medicines such as garlic, cranberry and raspberry in pregnancy (Level 3–4). Much of the literature is based on case reports with limited pharmacodynamic/kinetic studies. There are no clear data on the adverse herb–drug interactions during anaesthesia. As the risks of these interactions are unknown, it would be prudent for anaesthetists to explicitly ask their patients about their use of herbal medicines before surgery and prior to labour and birth. The European Society of Anaesthesiology and American Society of Anesthesiologists recommend that patients cease taking herbal medicines two weeks before surgery.

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A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines

Natural Product Communications ◽

10.1177/1934578x1601101131 ◽

2016 ◽

Vol 11 (11) ◽

pp. 1934578X1601101 ◽

Cited By ~ 3

Author(s):

Ahmet Aydιn ◽

Göknur Aktay ◽

Erdem Yesilada

Keyword(s):

Case Reports ◽

Herbal Medicines ◽

Significant Risk ◽

Toxicity Assessment ◽

Herbal Remedies ◽

Toxicity Tests ◽

Potential Health ◽

Local Tolerance

Herbal remedies have been used for thousands of years in worldwide traditional medicines for their potential health benefits. Although they are generally presumed safe unless a significant risk has been identified in humans, increasing number of case reports notify acute or chronic intoxications resulting from their use. This study aims to produce a scientific guide for the evaluation of traditional herbal medicines (THMs) in terms of their toxicity risks based on the published regulatory documents. For this purpose recommended in vitro and in vivo toxicity tests on medicinal products for human use issued by the international regulatory bodies are overviewed and they are then adopted to be used for the toxicity assessment of THMs. Accordingly, based on compilation of these issued regulations, the following tests are recommended for the toxicity assessment of THMs; in vitro cytotoxicity, genotoxicity, acute and repeated dose toxicity, carcinogenicity, reproductive and developmental toxicity, local tolerance tests, toxicokinetic studies, and additional toxicity tests including safety pharmacology, immunotoxicity and antigenicity, endocrine system toxicity, gastro-intestinal toxicity, renal and hepatotoxicity, and drug interaction studies. This study describes and discusses the applicability of these tests for the risk assessment in THMs.

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A Review of Herbal Medicines for Nausea and Vomiting of Pregnancy in Traditional Persian Medicine

Galen Medical Journal ◽

10.31661/gmj.v6i4.809 ◽

2017 ◽

Vol 6 (4) ◽

pp. 281-290

Author(s):

Shahrbanoo Abdolhosseini ◽

Fataneh Hashem Dabaghian ◽

Mitra Mehrabani ◽

Roshanak Mokaberinejad

Keyword(s):

Medicinal Plants ◽

Herbal Medicines ◽

Punica Granatum ◽

Human Studies ◽

Nausea And Vomiting ◽

Mentha Piperita ◽

Citrus Limon ◽

Cydonia Oblonga ◽

Mentha Spicata ◽

Myristica Fragrans Houtt

Nausea and vomiting of pregnancy (NVP) is one of the prevalent pregnancy complaints. This study was conducted to review the medicinal plants mentioned in Traditional Persian Medicine (TPM) for the treatment of NVP. A literature research was conducted on a number of main references of TPM, including the books of al-Qanun fī al-Teb, Zakhireye Kharazmshahi, Tadbir-al-Habali al- Atfal al-Sabiban and Makhzan-al-Adviah. Then, medicinal plants mentioned in TPM for treatment of NVP were determined and searched in electronic databases, including PubMed and Google Scholar to find studies that confirmed their efficacy. The search terms were ‘‘vomiting’’ or ‘‘nausea’’ or “emesis” and “pregnancy” and the name of each herb. Data were collected for the years 1990–2016. The findings included 10 plants. Citrus limon (Lemon), Citrus medica L. (Citron), Cydonia oblonga (Quince), Elletaria cardamomum (Cardamom), Mentha spicata L. (Spearmint), Menatha piperita (Mint), Myristica fragrans Houtt (Nutmeg), Pistacia lentiscus Linn. (Mastic), Punica granatum L. (Pomegranate), Malus domestica Borkh (Apple), and Piper cubeba L. are the most recommended medications for NVP. There is evidence in human studies for some of these medicinal plants (Mentha Piperita L., Citrus limon, Elletaria cardamom, and Cydonia oblonga Mill). The other mentioned herbs have not been evaluated during pregnancy. There is limited evidence to safely recommend these plants for NVP. Although some human studies have suggested the antiemetic effects of TPM remedies, their safety is not sufficiently documented in modern literature. Scientific studies on these medicinal plants during pregnancy are warranted to determine their safety. [GMJ.2017;6(4):281-90] DOI: 10.22086/gmj.v0i0.809

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