Diallyl disulfide suppresses the lipopolysaccharide-driven inflammatory response of macrophages by activating the Nrf2 pathway

2022 ◽  
Vol 159 ◽  
pp. 112760
Author(s):  
Xiu-Ning Zhang ◽  
Ning Zhao ◽  
Fang-Fang Guo ◽  
Yi-Ran Wang ◽  
Shi-Xuan Liu ◽  
...  
2013 ◽  
Vol 21 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Jae-Won Lee ◽  
Yong-Jun Choi ◽  
Jun-Ho Park ◽  
Jae-Young Sim ◽  
Yong-Soo Kwon ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Chaoliang Tang ◽  
Junmou Hong ◽  
Chengyun Hu ◽  
Chunxia Huang ◽  
Jie Gao ◽  
...  

Palmatine (PAL), a natural isoquinoline alkaloid, possesses extensive biological and pharmaceutical activities, including antioxidative stress, anti-inflammatory, antitumor, neuroprotective, and gastroprotective activities. However, it is unknown whether PAL has a protective effect against ischemic stroke and cerebral ischemia/reperfusion (I/R) injury. In the present study, a transient middle cerebral artery occlusion (MCAO) mouse model was used to mimic ischemic stroke and cerebral I/R injury in mice. Our study demonstrated that PAL treatment ameliorated cerebral I/R injury by decreasing infarct volume, neurological scores, and brain water content. PAL administration attenuated oxidative stress, the inflammatory response, and neuronal apoptosis in mice after cerebral I/R injury. In addition, PAL treatment also decreases hypoxia and reperfusion- (H/R-) induced neuronal injury by reducing oxidative stress, the inflammatory response, and neuronal apoptosis. Moreover, the neuroprotective effects of PAL were associated with the activation of the AMP-activated protein kinase (AMPK)/nuclear factor E2-related factor 2 (Nrf2) pathway, and Nrf2 knockdown offsets PAL-mediated antioxidative stress and anti-inflammatory effects. Therefore, our results suggest that PAL may be a novel treatment strategy for ischemic stroke and cerebral I/R injury.


2001 ◽  
Vol 120 (5) ◽  
pp. A468-A469
Author(s):  
S RAHMAN ◽  
B AMMORI ◽  
I MARTIN ◽  
G BARCLAY ◽  
M LARVIN ◽  
...  

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