Diallyl disulfide suppresses the lipopolysaccharide-driven inflammatory response of macrophages by activating the Nrf2 pathway

2022 ◽  
Vol 159 ◽  
pp. 112760
Author(s):  
Xiu-Ning Zhang ◽  
Ning Zhao ◽  
Fang-Fang Guo ◽  
Yi-Ran Wang ◽  
Shi-Xuan Liu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Diallyl Disulfide ◽  
Nrf2 Pathway

The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats

2014 ◽  
Vol 63 ◽  
pp. 174-185 ◽  
Author(s):  
In-Chul Lee ◽  
Sung-Hwan Kim ◽  
Hyung-Seon Baek ◽  
Changjong Moon ◽  
Seong-Soo Kang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Inflammatory Response ◽  
Oxidative Damage ◽  
Diallyl Disulfide ◽  
Protective Effects

scholarly journals 3,4,5-Trihydroxycinnamic Acid Inhibits Lipopolysaccharide-Induced Inflammatory Response through the Activation of Nrf2 Pathway in BV2 Microglial Cells

2013 ◽  
Vol 21 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Jae-Won Lee ◽  
Yong-Jun Choi ◽  
Jun-Ho Park ◽  
Jae-Young Sim ◽  
Yong-Soo Kwon ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Microglial Cells ◽  
Nrf2 Pathway ◽  
Bv2 Microglial Cells

Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway

2012 ◽  
Vol 93 (3) ◽  
pp. 491-497 ◽  
Author(s):  
Hui-Wen Cheng ◽  
Kock-Chee Lee ◽  
Khoot-Peng Cheah ◽  
Ming-Long Chang ◽  
Che-Wei Lin ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Nrf2 Pathway ◽  
Raw264.7 Macrophages ◽  
Haem Oxygenase

scholarly journals Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Chaoliang Tang ◽  
Junmou Hong ◽  
Chengyun Hu ◽  
Chunxia Huang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Inflammatory Response ◽  
Neuronal Apoptosis ◽  
Ischemia Reperfusion ◽  
Nrf2 Pathway ◽  
Cerebral Ischemia Reperfusion ◽  
Antioxidative Stress ◽  
Anti Inflammatory

Palmatine (PAL), a natural isoquinoline alkaloid, possesses extensive biological and pharmaceutical activities, including antioxidative stress, anti-inflammatory, antitumor, neuroprotective, and gastroprotective activities. However, it is unknown whether PAL has a protective effect against ischemic stroke and cerebral ischemia/reperfusion (I/R) injury. In the present study, a transient middle cerebral artery occlusion (MCAO) mouse model was used to mimic ischemic stroke and cerebral I/R injury in mice. Our study demonstrated that PAL treatment ameliorated cerebral I/R injury by decreasing infarct volume, neurological scores, and brain water content. PAL administration attenuated oxidative stress, the inflammatory response, and neuronal apoptosis in mice after cerebral I/R injury. In addition, PAL treatment also decreases hypoxia and reperfusion- (H/R-) induced neuronal injury by reducing oxidative stress, the inflammatory response, and neuronal apoptosis. Moreover, the neuroprotective effects of PAL were associated with the activation of the AMP-activated protein kinase (AMPK)/nuclear factor E2-related factor 2 (Nrf2) pathway, and Nrf2 knockdown offsets PAL-mediated antioxidative stress and anti-inflammatory effects. Therefore, our results suggest that PAL may be a novel treatment strategy for ischemic stroke and cerebral I/R injury.

Gut permeabillity and nitric oxide: Evidence for an endotoxin mediated inflammatory response in severe acute pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A469
Author(s):  
S RAHMAN ◽  
B AMMORI ◽  
I MARTIN ◽  
G BARCLAY ◽  
M LARVIN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Severe Acute Pancreatitis
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