5 YEARS OF THE SART CORS IVF DATA REGISTRY: QUANTIFYING THE IMPACT

Abstract A key measure of lung function in people with Cystic Fibrosis (CF) is Forced Expiratory Volume in the first second FEV1 percent predicted (FEV1pp). This study aimed to address challenges in identifying predictors of FEV1pp, specifically dealing with non-linearity and the censoring effect of death. Data was obtained from a large multi-centre Australian Cystic Fibrosis Data Registry (ACFDR). A linear mixed model was used to study FEV1pp as the endpoint. There were 3655 patients (52.4% male) included in our study. Restricted cubic splines were used to fit the non-linear relationship between age of visit and FEV1pp. The following predictors were found to be significant in the multivariate model: age of patient at visit, BMI z-score, age interaction with lung transplantation, insulin dependent diabetes, cirrhosis/portal hypertension, pancreatic insufficiency, Pseudomonas aeruginosa infection and baseline variability in FEV1pp. Those with P. aeruginosa infection had a lower mean difference in FEV1pp of 4.7 units, p < 0.001 compared to those who did not have the infection. Joint modelling with mortality outcome did not materially affect our findings. These models will prove useful for to study the impact of CFTR modulator therapies on rate of change of lung function among patients with CF.

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Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease – the perspective of cardiology

Cardiology in the Young ◽

10.1017/s1047951108002825 ◽

2008 ◽

Vol 18 (S2) ◽

pp. 116-123 ◽

Cited By ~ 35

Author(s):

Kathy J. Jenkins ◽

Robert H. Beekman III ◽

Lisa J. Bergersen ◽

Allen D. Everett ◽

Thomas J. Forbes ◽

...

Keyword(s):

Quality Improvement ◽

Cardiac Disease ◽

Interventional Cardiology ◽

National Database ◽

Quality Improvement Initiative ◽

Paediatric Cardiology ◽

Data Registry ◽

National Quality ◽

Adult Congenital ◽

The Impact

AbstractThis review includes a brief discussion, from the perspective of the pediatric cardiologist, of the rationale for creation and maintenance of multi-institutional databases of outcomes of the treatment of patients with congenital and paediatric cardiac disease, together with a history of the evolution of such databases, and a description of the current state of the art. A number of projects designed to have broad-based impact are currently in the design phase, or have already been implemented. Not surprisingly, most of the efforts thus far have focused on catheterization procedures and interventions, although some work examining other aspects of paediatric cardiology practice is also beginning. This review briefly describes several European and North American initiatives related to databases for pediatric and congenital cardiology including the Central Cardiac Audit Database of the United Kingdom, national database initiatives for pediatric cardiology in Switzerland and Germany, various database initiatives under the leadership of the Working Groups of The Association for European Paediatric Cardiology, the IMPACT Registry™ (IMproving Pediatric and Adult Congenital Treatment) of the National Cardiovascular Data Registry® of The American College of Cardiology Foundation® and The Society for Cardiovascular Angiography and Interventions (SCAI), the Mid-Atlantic Group of Interventional Cardiology (MAGIC) Catheterization Outcomes Project, the Congenital Cardiac Catheterization Project on Outcomes (C3PO), the Congenital Cardiovascular Interventional Study Consortium (CCISC), and the Joint Council on Congenital Heart Disease (JCCHD) National Quality Improvement Initiative. These projects, each leveraging multicentre data and collaboration, demonstrate the enormous progress that has occurred over the last several years to improve the quality and consistency of information about nonsurgical treatment for congenital cardiac disease. The paediatric cardiology field is well-poised to move quickly beyond outcome assessment and benchmarking, to collaborative quality improvement.

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Prior-Cancer Diagnosis in Men with Nonmetastatic Prostate Cancer and the Risk of Prostate-Cancer-Specific and All-Cause Mortality

ISRN Oncology ◽

10.1155/2014/736163 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6

Author(s):

Kristina Mirabeau-Beale ◽

Ming-Hui Chen ◽

Anthony V. D'Amico

Keyword(s):

Prostate Cancer ◽

Competing Risks ◽

Cancer Diagnosis ◽

Cox Regression ◽

Study Cohort ◽

Adjusted Risk ◽

Data Registry ◽

All Cause Mortality ◽

Seer Data ◽

The Impact

Purpose. We evaluated the impact a prior cancer diagnosis had on the risk of prostate-cancer-specific mortality (PCSM) and all-cause mortality (ACM) in men with PC. Methods. Using the SEER data registry, 166,104 men (median age: 66) diagnosed with PC between 2004 and 2007 comprised the study cohort. Competing risks and Cox regression were used to evaluate whether a prior cancer diagnosis impacted the risk of PCSM and ACM adjusting for known prognostic factors PSA level, age at and year of diagnosis, race, and whether PC treatment was curative, noncurative, or active surveillance (AS)/watchful waiting (WW). Results. At a median followup of 2.75 years, 12,453 men died: 3,809 (30.6%) from PC. Men with a prior cancer were followed longer, had GS 8 to 10 PC more often, and underwent WW/AS more frequently (P<0.001). Despite these differences that should increase the risk of PCSM, the adjusted risk of PCSM was significantly decreased (AHR: 0.66 (95% CI: (0.45, 0.97); P=0.033), while the risk of ACM was increased (AHR: 2.92 (95% CI: 2.64, 3.23); P<0.001) in men with a prior cancer suggesting that competing risks accounted for the reduction in the risk of PCSM. Conclusion. An assessment of the impact that a prior cancer has on life expectancy is needed at the time of PC diagnosis to determine whether curative treatment for unfavorable-risk PC versus AS is appropriate.

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Clinical outcomes following ICSI cycles using surgically recovered sperm and the impact of maternal age: 2004–2015 SART CORS registry

Journal of Assisted Reproduction and Genetics ◽

10.1007/s10815-018-1234-1 ◽

2018 ◽

Vol 35 (7) ◽

pp. 1239-1246

Author(s):

A. M. Mahesan ◽

S. Sadek ◽

V. Moussavi ◽

T. Vazifedan ◽

A. Majeed ◽

...

Keyword(s):

Clinical Outcomes ◽

Maternal Age ◽

The Impact ◽

Sart Cors

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The impact of Hurricane Katrina, a major natural disaster, on assisted reproductive outcomes through an analysis of 451,848 ART cycles

Scientific Reports ◽

10.1038/s41598-021-97402-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Olcha Meir ◽

Kuokkanen Satu ◽

Xianhong Xie ◽

Negassa Abdissa ◽

Pal Lubna ◽

...

Keyword(s):

Sex Ratio ◽

Hurricane Katrina ◽

Natural Disaster ◽

Preterm Delivery ◽

Spontaneous Abortion ◽

Perinatal Outcomes ◽

Extreme Stress ◽

The Impact ◽

Singleton Pregnancies ◽

Sart Cors

AbstractTo evaluate whether pregnancies conceived via assisted reproductive technology and exposed to Hurricane Katrina (HK), one of the most destructive natural disasters in United States history, were more prone to adverse perinatal outcomes, miscarriages, or sex disparities compared with pregnancies established but not directly exposed to the natural disaster. Retrospective cohort study. Women 18 years and older undergoing fresh ART cycles that resulted in singleton pregnancies and entered in the SART CORS database from 2004 to 2008. Incidence of full-term and preterm delivery, miscarriage rate, infant weight at birth, and infant sex ratio. Total follicle stimulating hormone (FSH) stimulation dosage and number of oocytes retrieved. Between January 2004 and December 2008, a total of 451,848 fresh autologous IVF cycles were recorded in SART CORS, leading to 190,624 pregnancies and 129,499 live births. After controlling for potential confounders, our results demonstrate no association between HK exposure and overall preterm deliveries (< 37 weeks) in women with singleton pregnancies conceived after ART. Other perinatal outcomes such as rate of spontaneous abortion or infant weight at birth in the exposed and unexposed groups were also not associated with HK. A comparison of pre and post disaster sex ratios revealed fewer males were born after HK (51.0% vs. 49.4%), showing a trend of decreased male infant births that was least in part associated with HK (CI 0.81–1.01; p = 0.07). Exposure to HK did not appear to affect perinatal outcomes such as the rate of preterm delivery or the rate of spontaneous abortion. Extreme stress may be a factor that contributes to a reduced male to female secondary sex ratio.

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Clinical outcomes following ICSI cycles using surgically recovered sperm and the impact of maternal age: 2004-2015 SART CORS registry

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.07.278 ◽

2018 ◽

Vol 110 (4) ◽

pp. e92

Author(s):

A.M. Mahesan ◽

S. Sadek ◽

V. Moussavi ◽

A. Majeed ◽

T. Cunningham ◽

...

Keyword(s):

Clinical Outcomes ◽

Maternal Age ◽

The Impact ◽

Sart Cors

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Report from The International Society for Nomenclature of Paediatric and Congenital Heart Disease: cardiovascular catheterisation for congenital and paediatric cardiac disease (Part 1 – Procedural nomenclature)

Cardiology in the Young ◽

10.1017/s104795111000185x ◽

2011 ◽

Vol 21 (3) ◽

pp. 252-259 ◽

Cited By ~ 25

Author(s):

Lisa Bergersen ◽

Allen Dale Everett ◽

Jorge Manuel Giroud ◽

Gerard R. Martin ◽

Rodney Cyril George Franklin ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

International Society ◽

Cardiac Disease ◽

Congenital Heart ◽

Interventional Cardiology ◽

Universal System ◽

Data Registry ◽

Congenital Cardiac Disease ◽

The Impact

AbstractInterventional cardiology for paediatric and congenital cardiac disease is a relatively young and rapidly evolving field. As the profession begins to establish multi-institutional databases, a universal system of nomenclature is necessary for the field of interventional cardiology for paediatric and congenital cardiac disease. The purpose of this paper is to present the results of the efforts of The International Society for Nomenclature of Paediatric and Congenital Heart Disease to establish a system of nomenclature for cardiovascular catheterisation for congenital and paediatric cardiac disease, focusing both on procedural nomenclature and on the nomenclature of complications associated with interventional cardiology. This system of nomenclature for cardiovascular catheterisation for congenital and paediatric cardiac disease is a component of The International Paediatric and Congenital Cardiac Code. This manuscript is the first part of a two-part series. Part 1 will cover the procedural nomenclature associated with interventional cardiology as treatment for paediatric and congenital cardiac disease. This procedural nomenclature of The International Paediatric and Congenital Cardiac Code will be used in the IMPACT Registry™ (IMproving Pediatric and Adult Congenital Treatment) of the National Cardiovascular Data Registry®of The American College of Cardiology. Part 2 will cover the nomenclature of complications associated with interventional cardiology as treatment for paediatric and congenital cardiac disease.

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The impact of staple line reinforcement on perioperative staple line leak and bleeding rates following sleeve gastrectomy: An analysis of MBSAQIP data registry

Surgery for Obesity and Related Diseases ◽

10.1016/j.soard.2018.09.099 ◽

2018 ◽

Vol 14 (11) ◽

pp. S64-S65

Author(s):

Matthew A Cunningham-Hill ◽

Michael Mazzei ◽

Michael A Edwards

Keyword(s):

Sleeve Gastrectomy ◽

Staple Line ◽

Staple Line Reinforcement ◽

Staple Line Leak ◽

Data Registry ◽

The Impact

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Outcomes of SARS-CoV-2 infected pregancies after medically assisted reproduction

Human Reproduction ◽

10.1093/humrep/deab218 ◽

2021 ◽

Author(s):

◽

Baris Ata ◽

Luca Gianaroli ◽

Kersti Lundin ◽

Saria Mcheik ◽

...

Keyword(s):

Data Collection ◽

Assisted Reproduction ◽

Current Data ◽

University Hospital ◽

Human Reproduction ◽

Selective Reporting ◽

Online Data ◽

Medically Assisted Reproduction ◽

Data Registry ◽

The Impact

Abstract Study question What is the impact of SARS-CoV-2 infection on the outcome of a pregnancy after medically assisted reproduction? Summary answer Our results suggest that medically assisted reproduction (MAR) pregnancies are not differentially affected by SARS-CoV-2 infection compared to spontaneous pregnancies. What is known already Information on the effects of COVID-19 on pregnancy after MAR is scarce when women get infected during MAR or early pregnancy, even though such information is vital for informing women seeking pregnancy. Study design, size, duration Data from SARS-CoV-2 affected MAR pregnancies were collected between May 2020 and June 2021 through a voluntary data collection, organised by the European Society of Human Reproduction and Embryology (ESHRE). Participants/materials, setting, methods All ESHRE members were invited to participate to an online data collection for SARS-CoV-2-infected MAR pregnancies. Main results and the role of chance The dataset includes 80 cases from 32 countries, including 67 live births, 10 miscarriages, 2 stillbirths and 1 maternal death. An additional 25pregnancies were ongoing at the time of writing. Limitations, reasons for caution An international data registry based on voluntary contribution can be subject to selective reporting with possible risks of over- or under-estimation. Wider implications of the findings The current data can be used to guide clinical decisions in the care of women pregnant after MAR, in the context of the COVID-19 pandemic. Study funding/competing interest(s) The authors acknowledge the support of ESHRE for the data registry and meetings. JT reports grants or contracts from Sigrid Juselius Foundation, EU and Helsinki University Hospital Funds, outside the scope of the current work. The other authors declare that they have no conflict of interest.

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Formation of Lunar Craters and Bright Rays as a Result of Meteorite Impacts

Symposium - International Astronomical Union ◽

10.1017/s0074180900178404 ◽

1962 ◽

Vol 14 ◽

pp. 415-418

Author(s):

K. P. Stanyukovich ◽

V. A. Bronshten

Keyword(s):

Explosive Charge ◽

The Moon ◽

Meteorite Impacts ◽

The Earth ◽

Lunar Craters ◽

The Impact

The phenomena accompanying the impact of large meteorites on the surface of the Moon or of the Earth can be examined on the basis of the theory of explosive phenomena if we assume that, instead of an exploding meteorite moving inside the rock, we have an explosive charge (equivalent in energy), situated at a certain distance under the surface.

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