DOES THE LOW SPERM CONCENTRATION ON THE DAY OF INTRAUTERINE INSEMINATION (IUI) AFFECT THE REPRODUCTIVE OUTCOME OF IUI CYCLES

AbstractBackground: Infertility in developing countries is higher at 30% compared to developed countries at 5-8%. The factors that influence infertility are maternal (women) age and sperm factors. Therapy in handling infertility in the form of Assisted Reproductive Technology (ART) with one of them is Intrauterine Insemination (IUI). The success rate of IUI is the percentage of IUI programs that give results as desired depending on the type of calculation used such as pregnancy rate or live birth rate. Method: This research is a literature review. The research question with PICO standard is "What is relationship between woman's age and sperm quality with the success of Intrauterine Insemination?". 70 literatures were obtained from Cochrane, Sciencedirect, PubMed, and google scholar databases. Literature screening was done by looking at the inclusion and exclusion criteria that have been set, so that 7 literature will be reviewed. Results: From all the literature on the relationship of woman's age with the pregnancy rate in the IUI process stated that there was a significant relationship between the age of the woman with the success of IUI. Most of literature (75%) on the relationship of sperm quality with pregnancy rates in the IUI process states that there is a relationship between sperm quality and the success of IUI. The percentage of pregnancies in the IUI program can reach more than 10% with a sperm concentration >10x106/ml. Conclusion: From a review of 7 literature, the age of women who are ideal for IUI is 20-35 years with a pregnancy of 20%. In a sperm concentration >10x106/ml and sperm morphology ≥ 5% can get >10% pregnancy rate, and a pregnancy rate of >8% on sperm motility ≥ 75%.

Download Full-text

Sperm concentration on the intrauterine artificial insemination in swine

Ciência e Agrotecnologia ◽

10.1590/s1413-70542009000600030 ◽

2009 ◽

Vol 33 (6) ◽

pp. 1671-1674

Author(s):

Joana Miller ◽

Ana Luísa Neves Alvarenga ◽

Luis David Solis Murgas ◽

Adriana Cristina da Silva ◽

Ricardo Sales Araújo ◽

...

Keyword(s):

Litter Size ◽

Reproductive Performance ◽

Artificial Insemination ◽

Intrauterine Insemination ◽

Sperm Concentration ◽

Conception Rate ◽

Cervical Canal ◽

Significant Difference ◽

Estrus Detection ◽

Farrowing Rate

The aim of this work was to evaluate the efficiency of the intrauterine insemination (IUI) in swine, considering the conception rate, farrowing rate, litter size (alive born pigs). For the IUI, the females had been insemination at 24 and 48 hours after the estrus detection, and the inseminating doses of 500 million, 1 billion, 1.5 billion and 2 billion spermatozoa in 20 mL extender had been used. The procedure of catheter insertion through the cervical canal was successfully performed in 97.9% of the females. The conception rate was 6.3% in the IUI. The farrowing rate in IUI was 87.2% but the farrowing rate was 100% for the sperm concentration of 500 million. Regarding the number of born pigs and alive born pigs observed in females inseminated with IUI, no significant difference was observed (p > 0.05). The concentration of 500 x 10(6) spermatozoa in 20 mL extender in the intrauterine insemination resulted in an optimal reproductive performance.

Download Full-text

The Fertility Outcome of Royal Jelly versus Intra Uterine Insemination: A Pilot Randomized Controlled Trial Study

Jundishapur Journal of Natural Pharmaceutical Products ◽

10.5812/jjnpp.107420 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Tahereh Fathi Najafi ◽

Nayereh Khadem ◽

Narjes Bahri ◽

Mojtaba Meshkat ◽

Shirin Sadri ◽

...

Keyword(s):

Royal Jelly ◽

Intrauterine Insemination ◽

Controlled Trial ◽

Treatment Success ◽

Sperm Concentration ◽

Success Rates ◽

Similar Treatment ◽

Significant Difference ◽

Study Power ◽

Sterile Plastic

Background: The popularity of complementary and alternative medicine is on the rise. Objectives: The current study aimed to compare the effect of vaginal royal jelly with intrauterine insemination (IUI) on sub-fertility in men. Methods: The sample size was estimated as 27 subjects, based on a study power and confidence interval of 80% and 95%, respectively. The study was conducted in Mashhad, in the Northeast of Iran, from 2015 to 2017. Men with sub-fertility (asthenozoospermia, defined as total sperm motility below 40% and sperm concentration below 20 million/mL), with healthy wives, based on salpingography, participated in this study. Patients were assigned to the royal jelly group, which received 5 grams of royal jelly, and the IUI group, which received 75 units of Follicle Stimulating Hormone (FSH) from the second day of the menstrual cycle. Semen samples were collected in sterile plastic caps after 72 hours of sexual abstinence by normal sexual intercourse. Samples were prepared using the standard swim-up technique. Results: This study showed no significant difference between groups concerning spousal age, occupation, education (husband and wife), and social class (P = 0.745). Also, no significant difference was found between groups concerning fertility success rate (P = 0.573). Conclusions: Based on similar treatment success rates of royal jelly and IUI, it seems that royal jelly can be considered as an alternative to IUI.

Download Full-text

Effects of Sperm Parameters on Pregnancy Rate in Patients Undergoing Intrauterine Insemination

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2020.1040 ◽

2020 ◽

pp. 1

Author(s):

Mehmet Solakhan ◽

Mustafa Demir

Keyword(s):

Intrauterine Insemination ◽

Sperm Count ◽

Sperm Concentration ◽

Sperm Parameters ◽

Motile Sperm ◽

Progressive Motility ◽

Age Related ◽

Significant Difference ◽

Sperm Volume ◽

Infertile Couples

OBJECTIVE: In this study, the effects of sperm parameters on the success of intrauterine insemination were investigated. STUDY DESIGN: The data from 309 infertile couples who were admitted between 2012-2018 without a female factor were analyzed retrospectively and included in the study. After the administration of gonadotropin and hCG (5000-10000 IU), single insemination was performed in 36-40 hours in all cycles. All couples underwent routine infertility screening. The relationship between sperm parameters (motility, morphology, sperm count), patient age, duration of infertility with intrauterine insemination success was evaluated.RESULTS: There was no statistically significant difference between the two groups in terms of mean age and age related-parity. There was no statistically significant difference between male ages, liquefaction, and sperm volumes between the two groups (p=0.898, p=0.448, p=0.651). Before washing; There was a statistically significant difference between the sperm concentration, percentage of total motile sperm, percentage of progressive motility sperm, percentage of normal sperm morphology, and total sperm count between the two groups (p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.0001). After sperm washing; the results were similar to those obtained before washing. While statistically significant difference was observed between sperm volume and sperm concentrations (p=0.023, p=0.018), no significant difference was observed between the two groups in total sperm count (p=0.612).CONCLUSION: As a result, during the application of intrauterine insemination to infertile couples, total motile sperm count, progressive motility sperm count ratio and high sperm ratio with normal morphology used in order to increase pregnancy success can be considered as criteria that increase the chances of success.

Download Full-text

Changes of Quality of Semen after Swim up Method during Intrauterine Insemination: A Single Centered Experience in Dhaka City

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v4i1.38287 ◽

2018 ◽

Vol 4 (1) ◽

pp. 54-57

Author(s):

Shafeya Khanam ◽

Morium Faruque Shati ◽

Muqsuda Ashraf Shuvro ◽

Sharmin Ahmed ◽

Trifa Obayed ◽

...

Keyword(s):

Intrauterine Insemination ◽

Semen Analysis ◽

Sperm Concentration ◽

Cross Sectional Study ◽

World Health ◽

Dhaka City ◽

Cross Sectional ◽

Before And After ◽

The Mean

Background: Quality of semen is very important during intrauterine insemination.Objectives: The purpose of the present study was to observe the changes of quality of semen after swim up method during intrauterine insemination.Methodology: This analytical type of cross-sectional study was carried out at a private infertility centre (Central Hospital Limited, Dhaka) in Dhaka city of Bangladesh from January 2012 to December 2017 for a period of 6 years. Infertile couples who already had undergone natural cycles of super-ovulation for six months or whose duration of infertility was more than one year were included. Semen samples were collected by the process of masturbation in semen production room after three days of abstinence in sterile, labelled container. After production all samples were placed in an incubator at 37 degrees Celsius for 30 minutes for liquefaction. Routine semen analysis was performed using World Health Organizations’ (WHO) semen analysis criteria. Then the samples were randomly assigned to be processed either with swim-up or density-gradient procedure.Result: A total number of 789 male respondents were recruited for this study. The mean age with SD of the study population was 28.96±5.382 with the range of 19 to 46 years. The mean changes of sperm concentration before and after swim up method was 52.70±42.88 with the 95% confidence of 49.58 to 55.82 (p=0.000). The mean changes of sperm motility before and after swim up method was 29.03±14.849 with the 95% confidence of 30.11 to 27.95 (p=0.000). The mean changes of sperm morphology before and after swim up method was 23.96±11.328 (p=0.000).Conclusion: There is a significant changes of quality of semen after swim up method during intrauterine inseminationJournal of National Institute of Neurosciences Bangladesh, 2018;4(1): 54-57

Download Full-text

Evaluation of a serum 17-hydroxyprogesterone as predictor of semen parameter(s) improvement in men undergoing medical treatment for infertility

Canadian Urological Association Journal ◽

10.5489/cuaj.6846 ◽

2020 ◽

Vol 15 (7) ◽

Author(s):

Thiago Fernandes Negris Lima ◽

Evgeniya Rakitina ◽

Ruben Blachman-Braun ◽

Ranjith Ramasamy

Keyword(s):

Medical Therapy ◽

Semen Quality ◽

Intrauterine Insemination ◽

Sperm Concentration ◽

Rank Test ◽

Motile Sperm ◽

Semen Parameter ◽

Infertile Men ◽

Quality Upgrading ◽

17 Hydroxyprogesterone

Introduction: The goal of medical therapy for infertile men with testosterone deficiency (TD) is to improve intratesticular testosterone (ITT). There is a gap in knowledge to identify those who will respond with semen parameter(s) improvement. We hypothesized that serum 17-hydroxyprogesterone (17-OHP) — a marker of ITT — can be used to predict improvement of semen parameter(s). Methods: Between July 2018 and January 2020, we conducted a prospective study of 31 men with primary infertility, TD, and secondary hypogonadism receiving clomiphene citrate (CC) and/or human chorionic gonadotropin (hCG) for three months. We assessed baseline and followup hormones, including testosterone, 17-OHP, semen parameter(s), and demographics. Semen quality upgrading was based on assisted reproduction eligibility: in-vitro fertilization (<5 million), intrauterine insemination (IUI) (5–9 million), and natural pregnancy (>9 million). Variables were compared using the Mann-Whitney U or Wilcoxon rank test. Results: Twenty-one men received CC and 10 received CC/hCG. Median followup was 3.7 (3.3–5.1) months. Sixteen men upgraded semen quality. Six of 10 men with baseline total motile sperm count (TMSC) of 0 had motile sperm after treatment, and 11/20 men with TMSC<5 upgraded semen quality into TMSC>5 range. Low 17-OHP was the only factor that predicted semen quality upgrading. Men with 17-OHP ≤55 ng/dL upgraded semen quality and improved hormones, whereas men with 17-OHP >55 ng/dL did not upgrade semen quality. Conclusions: Medical therapy for infertile men with TD resulted in the improvement of sperm concentration, TMSC, testosterone, and 17-OHP. Semen quality upgrading appears to be more significant in patients with low 17-OHP, suggesting that ITT can be used as a biomarker to predict semen parameter(s) improvement.

Download Full-text

The Prediction of Sperm Chromatin Structure Assay (SCSA) Parameters for Outcomes of Intrauterine Insemination

10.21203/rs.3.rs-127024/v1 ◽

2020 ◽

Author(s):

Jiangman Gao ◽

Liying Yan ◽

Ying Huang ◽

Hui Jiang ◽

Yuanyuan Wang ◽

...

Keyword(s):

Dna Fragmentation ◽

Pregnancy Loss ◽

Loss Rate ◽

Intrauterine Insemination ◽

Sperm Concentration ◽

Clinical Pregnancy ◽

Sperm Chromatin ◽

Sperm Dna Fragmentation ◽

Female Age ◽

Sperm Dna

Abstract Background: Many studies have assessed the association between sperm DNA fragmentation and outcomes of ART. But the published papers have not offered enough evidence about whether sperm DNA fragmentation tests could make suggestions to predict intrauterine insemination (IUI) outcomes. The aim of this study was to assess whether the sperm chromatin structure assay (SCSA) parameters, sperm DNA fragmentation index (DFI) and high DNA stainability (HDS), could be used as predictors for treatment outcomes in IUI program.Methods: A retrospective cohort study was conducted at a large reproductive medicine center. 1139 IUI cycles from 1139 couples were studied. The association of SCSA parameters with the clinical pregnancy and early pregnancy loss after IUI were analyzed. Results: Clinical pregnancy rate per cycle in DFI<15%, 15%≤DFI<30%, and DFI≥30% groups were 11.1%, 7.3%, and 8.9%, respectively, with no statistical differences between the groups (P=0.127). Pregnancy loss rate were 24.3%, 27.6%, and 14.3%, respectively, with no statistical differences (P=0.762). Clinical pregnancy rate per cycle in HDS≤15% and HDS>15% groups were 9.8% and 7.5%, respectively, with no significant difference (P=0.468), and the pregnancy loss rate were 26.2% and 0, respectively, and also no statistical difference (P=0.191). Multivariate logistic regression analysis showed a higher rate of clinical pregnancy in couples with a younger female (OR=0.90, 95% CI: 0.83-0.97, P=0.007), and in couples with a male who had higher sperm concentration after washing (OR=1.02, 95% CI: 1.00-1.04, P=0.035). A higher risk of pregnancy loss was observed with increased female age (OR= 1.43, 95% CI:1.09-1.89, P=0.010) and lower sperm concentration after washing (OR= 0.92, 95% CI: 0.84-0.99, P= 0.029). Conclusions: Sperm DFI and HDS were not significantly correlated with clinical pregnancy and pregnancy loss in cycles of IUI. Female age and motile sperm concentration had statistically significant effects on both clinical pregnancy and pregnancy loss after IUI treatment.

Download Full-text