Inhibition of in vitro Starch Digestion by Ascorbyl Palmitate and Its Inclusion Complex with Starch

The content of this investigation was to study the influence of β-cyclodextrin and hydroxy propyl-β-cyclodextrin complexation on enhancement of solubility and dissolution rate of isradipine. Based on preliminary phase solubility studies, solid complexes prepared by freeze drying method in 1:1 molar ratio were selected and characterized by DSC for confirmation of complex formation. Prepared solid dispersions were evaluated for drug content, solubility and in vitro dissolution. The physical stability of optimized formulation was studied at refrigerated and room temperature for 2 months. Solid state characterization of optimized complex performed by DSC and XRD studies. Dissolution rate of isradipine was increased compared with pure drug and more with HP-β-CD inclusion complex than β-CD. DSC and XRD analyzes that drug was in amorphous form, when the drug was incorporated as isradipine β-CD and HP-β-CD inclusion complex. Stability studies resulted in low or no variations in the percentage of complexation efficiency suggesting good stability of molecular complexes. The results conclusively demonstrated that the enhancement of solubility and dissolution rate of isradipine by drug-cyclodextrin complexation was achieved.

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Effects of physicochemical and structural properties of single and double feedstuffs derived from different botanic sources on in vitro starch digestion and glucose release kinetics

Journal of Animal Physiology and Animal Nutrition ◽

10.1111/jpn.13512 ◽

2021 ◽

Author(s):

Qingzhen Zhong ◽

Mingye Li ◽

Emmanuel M. Atiba ◽

Yulin Yin ◽

Qian Yang ◽

...

Keyword(s):

Structural Properties ◽

Release Kinetics ◽

Starch Digestion ◽

Glucose Release ◽

Physicochemical And Structural Properties

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Cooking of short, medium and long-grain rice in limited and excess water: Effects on microstructural characteristics and gastro-small intestinal starch digestion in vitro

LWT ◽

10.1016/j.lwt.2021.111379 ◽

2021 ◽

Vol 146 ◽

pp. 111379

Author(s):

Masatsugu Tamura ◽

Chisato Kumagai ◽

Lovedeep Kaur ◽

Yukiharu Ogawa ◽

Jaspreet Singh

Keyword(s):

Starch Digestion ◽

Microstructural Characteristics ◽

Excess Water ◽

Water Effects ◽

Small Intestinal

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Synthesis, characterization and in vitro release studies of a new acetazolamide–HP-β-CD–TEA inclusion complex

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2007.03.037 ◽

2008 ◽

Vol 43 (3) ◽

pp. 464-470 ◽

Cited By ~ 40

Author(s):

Gladys E. Granero ◽

Marcos M. Maitre ◽

Claudia Garnero ◽

Marcela R. Longhi

Keyword(s):

Inclusion Complex ◽

In Vitro Release ◽

Release Studies ◽

Vitro Release

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MICROSPECTROPHOTOMETRY OF NEWLY SYNTHESIZED STARCH IN SITU

Journal of Histochemistry & Cytochemistry ◽

10.1177/18.6.439 ◽

1970 ◽

Vol 18 (6) ◽

pp. 439-449

Author(s):

GEORGE E. WHEELER

Keyword(s):

Absorption Maximum ◽

In Vitro Studies ◽

Phosphate Solution ◽

Starch Digestion ◽

Spectral Curves ◽

Similarities And Differences

Many of the cells in stem sections of several Commelinaceae species synthesized much new starch when incubated in buffered 1% glucose 1-phosphate solution. The starch appeared in the cytoplasm rather than in the plastids. Although the starch I2-KI color was uniform within any one cell, there was considerable variation from cell to cell, even in the same section. The colors with I2-KI ranged from blue, through purples to magenta and mahogany. Tests with α-amylase and with β-amylase showed the starch to be amylose. Microspectrophotometrically determined extinction curves, based on the new starch in situ, varied with the visualized color. As expected, starch which stained blue with I2-KI had an absorption maximum in the orange-red wavelengths above 600 mµ; increasingly red I2-KI colors were characterized by shifts of the absorption maximum further into the shorter wavelengths. The course of new starch digestion by α-amylase and by β-amylase was followed visually and with the microspectrophotometer. Similarities and differences between these spectral curves and those published for in vitro studies are pointed out. The difficulties met with in using the microspectrophotometric method are discussed.

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BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLEX ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

INDIAN DRUGS ◽

10.53879/id.52.11.10325 ◽

2015 ◽

Vol 52 (11) ◽

pp. 19-23

Author(s):

J Shaikh ◽

◽

S. V. Deshmane ◽

R. N Purohit ◽

K. R. Biyani

Keyword(s):

Inclusion Complex ◽

Solid Dispersion ◽

Water Soluble ◽

In Vitro Dissolution ◽

Phase Solubility ◽

Solubility Study ◽

Cyclodextrin Inclusion ◽

Poorly Water Soluble ◽

Cyclodextrin Inclusion Complex

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

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Impact of food processing on postprandial glycaemic and appetite responses in normoglycaemic adults: a randomized, controlled trial

Food & Function ◽

10.1039/d1fo02304g ◽

2022 ◽

Author(s):

Maryam S Hafiz ◽

Matthew D Campbell ◽

Nicolas Orsi ◽

Georgia Mappa ◽

Caroline Orfila ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Food Processing ◽

Controlled Trial ◽

Glycaemic Index ◽

In Vitro Studies ◽

Mechanical Processing ◽

Starch Digestion ◽

Randomized Controlled

Chickpeas are among the lowest glycaemic index carbohydrate food eliciting protracted digestion and enhanced satiety responses. In vitro studies suggest that mechanical processing of chickpeas significantly increases starch digestion. However,...

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