Role of oxidative stress in impaired insulin signaling associated with exercise-induced muscle damage

2013 ◽  
Vol 65 ◽  
pp. 1265-1272 ◽  
Author(s):  
Wataru Aoi ◽  
Yuji Naito ◽  
Toshikazu Yoshikawa
Keyword(s):  
Oxidative Stress ◽  
Muscle Damage ◽  
Insulin Signaling ◽  
Impaired Insulin ◽  
Exercise Induced

scholarly journals Protective Role of Vitamin C Intake on Muscle Damage in Male Adolescents Performing Strenuous Physical Activity

2018 ◽  
Vol 6 (9) ◽  
pp. 1594-1598 ◽  
Author(s):  
Shreef G. N. Gabrial ◽  
Marie-Christine R. Shakib ◽  
Gamal N. Gabrial
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Muscle Damage ◽  
Inflammatory Markers ◽  
Inflammatory Responses ◽  
Plasma Concentrations ◽  
Male Adolescents ◽  
Strenuous Physical Activity ◽  
Exercise Induced

BACKGROUND: Strenuous non-regular exercise increases reactive oxygen species ROS level leading to an impaired balance between the endogenous antioxidant defence system and the free radicals production. Antioxidants intake can detoxify the peroxides produced during exercise, attenuating the inflammatory responses and therefore may prevent exercise-induced muscle damage. AIM: The purpose of this study was to determine the role of vitamin C intake in attenuating markers of muscle damage, oxidative stress and inflammatory responses in male adolescents performing the non-regular strenuous exercise. MATERIAL AND METHODS: Twenty recreationally active male adolescents were assigned to participate in the study. Eligible subjects performed strenuous recreational exercise (2-3 times per week) were randomly divided into two groups: The vitamin C (VC) group that consumed 500 mg of capsulated vitamin C after breakfast for a period of 90 days and the placebo (PL) group that consumed identical capsules in form and aspect that contained 500 mg of maltodextrin for the same period. Aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH) were assessed for muscle damage. Malondialdehyde (MDA) was evaluated as a marker of lipid peroxidation. Plasma creatinine, uric acid and urea were determined to monitor kidney function. C-reactive protein, a marker of systemic inflammation was also measured. RESULTS: In comparison between PL and VC groups, the plasma concentrations of muscle damage markers, oxidative stress markers, kidney function and inflammatory markers showed no significant difference in their baseline values (P > 0.05). The plasma concentrations of CK, LDH, MDA, urea, uric acid and CRP were significantly decreased in the VC group (P < 0.05) as compared to their values before the intake of vitamin C. CONCLUSION: The present results support the intake of vitamin C as an antioxidant for attenuating exercise-induced muscle damage, oxidative stress and inflammatory markers in male adolescents performing the strenuous physical activity.

scholarly journals Physical Activity and Oxidative Stress - A Potential Role of L- Carnitine as an Antioxidant: A Review

2021 ◽  
Vol 8 (S1-Feb) ◽  
pp. 12-18
Author(s):  
Jyothsna Karanth ◽  
Dakshayini C
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Muscle Damage ◽  
Performance Enhancement ◽  
Antioxidant Properties ◽  
Good Health ◽  
Chronic Fatigue ◽  
Balanced Diet ◽  
Exercise Induced

Regular physical activity, along with a balanced diet, formsan important factor for the maintenance of good health. However, strenuousexerciseincreases the production of free radicals (FR) and reactive oxygen and nitrogen species (RONS), leads to toxicity, resulting in chronic fatigue, injuries. The overproduction of RONS is involved in muscular fatigue, many diseases, and aging. However, FRs are essential for the functioning of the immune system and certain metabolic functions.The increase in oxidants compared to antioxidant leads to oxidative stress. Nowadays, antioxidants are supplemented to reduce muscle damage incurred during exercise, which has drawn the attention of the athletic population. L- Carnitine being ergogenic, acts as an antioxidant during recovery from exercise, thereby attenuate oxidative stress, which may then decrease exercise-induced muscle damage. Despite increasing research on antioxidant properties for carnitine in several pathologies such as diabetes, hypertension, renal, neurodegenerative conditions, and liver disease, less has been documented on it against oxidative stress induced by exercise. This review may help researchers who are interested in athletic performance enhancement and sports nutrition.

Anti-fatigue effect of Lepidium meyenii Walp. (Maca) on preventing mitochondria-mediated muscle damage and oxidative stress in vivo and vitro

2021 ◽  
Vol 12 (7) ◽  
pp. 3132-3141
Author(s):  
Hongkang Zhu ◽  
Wenqian Xu ◽  
Ning Wang ◽  
Wenhao Jiang ◽  
Yuliang Cheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Muscle Damage ◽  
Aqueous Extract ◽  
Fatigue Effect ◽  
Lepidium Meyenii ◽  
Exercise Induced ◽  
And Oxidative Stress

We investigated the role of Maca aqueous extract on muscle during exercise-induced fatigue both in vivo and in vitro..

Effect of a Single Dose of Green Tea Polyphenols on the Blood Markers of Exercise-Induced Oxidative Stress in Soccer Players

2012 ◽  
Vol 22 (6) ◽  
pp. 486-496 ◽  
Author(s):  
Ewa Jówko ◽  
Jaroslaw Sacharuk ◽  
Bozena Balasinska ◽  
Jacek Wilczak ◽  
Malgorzata Charmas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Single Dose ◽  
Muscle Damage ◽  
Green Tea ◽  
Green Tea Polyphenols ◽  
Soccer Players ◽  
Muscle Endurance ◽  
Endurance Test ◽  
Acute Ingestion ◽  
Exercise Induced

Purpose:To evaluate the effect of acute ingestion of green tea polyphenols (GTP) on blood markers of oxidative stress and muscle damage in soccer players exposed to intense exercise.Methods:This randomized, double-blinded study was conducted on 16 players during a general preparation period, when all athletes participated in a strength-training program focused on the development of strength endurance. After ingestion of a single dose of GTP (640 mg) or placebo, all athletes performed an intense muscle-endurance test consisting of 3 sets of 2 strength exercises (bench press, back squat) performed to exhaustion, with a load at 60% 1-repetition maximum and 1-min rests between sets. Blood samples were collected preexercise, 5 min after the muscle-endurance test, and after 24 hr of recovery. Blood plasma was analyzed for the concentrations of thiobarbituric acid–reacting substances (TBARS), uric acid (UA), total catechins, total antioxidant status (TAS), and activity of creatine kinase (CK); at the same time, erythrocytes were assayed for the activity of superoxide dismutase (SOD).Results:In both groups, plasma TBARS, UA, and TAS increased significantly postexercise and remained elevated after a 24-hr recovery period. SOD activity in erythrocytes did not change significantly in response to the muscle-endurance test, whereas in both groups plasma CK activity increased significantly after 24 hr of recovery. Acute intake of GTP cased a slight but significant increase in total plasma catechins. However, GTP was found not to exert a significant effect on measured parameters.Conclusions:Acute ingestion of GTP (640 mg) does not attenuate exercise-induced oxidative stress and muscle damage.

Protective role of l-carnitine supplementation against exhaustive exercise induced oxidative stress in rats

2011 ◽  
Vol 668 (3) ◽  
pp. 407-413 ◽  
Author(s):  
Elif Şıktar ◽  
Deniz Ekinci ◽  
Erdinç Şıktar ◽  
Şükrü Beydemir ◽  
İlhami Gülçin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Exhaustive Exercise ◽  
Carnitine Supplementation ◽  
Exercise Induced

Protective Role of Polysaccharides from Gynostemma pentaphyllum Makino Supplementation against Exhaustive Swimming Exercise-Induced Oxidative Stress in Liver and Skeletal Muscle of Mice

2014 ◽  
Vol 962-965 ◽  
pp. 1231-1234
Author(s):  
Hui Huang ◽  
Bo Qi
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Protective Role ◽  
Swimming Exercise ◽  
Control Group ◽  
High Dose ◽  
Gynostemma Pentaphyllum ◽  
Exercise Induced ◽  
Different Doses

The objective of this study was to investigate the protective role of polysaccharide fromGynostemma pentaphyllumMakino (PGP) supplementation against exhaustive swimming exercise-induced oxidative stress. A total of 48 mice were randomly divided into four groups: control, low-dose, medium-dose, and high-dose PGP supplementation groups. The control group received distilled water and the supplementation groups received different doses of PGP (50, 100 and 200 mg/kg body weight) by gavage once a day for 28 consecutive days. After 28 days, the mice performed an exhaustive swimming exercise, and some biochemical parameters related to oxidative stress, including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA), were measured. The results showed that PGP supplementation could increase SOD, GPx and CAT contents, as well as decrease MDA contents in the liver and skeletal muscle of mice, which suggests that PGP supplementation has a protective role against exhaustive swimming exercise-induced oxidative stress.

Role of brain macrophages on IL-1β and fatigue following eccentric exercise-induced muscle damage

2010 ◽  
Vol 24 (4) ◽  
pp. 564-568 ◽  
Author(s):  
Martin D. Carmichael ◽  
J. Mark Davis ◽  
E. Angela Murphy ◽  
James A. Carson ◽  
N. Van Rooijen ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Brain Macrophages ◽  
Exercise Induced
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