Extracellular Vesicles as Drug Delivery Vehicles for Potent Redox Enzyme Catalase to Treat Parkinson's Disease

2018 ◽  
Vol 128 ◽  
pp. S18 ◽  
Author(s):  
Matthew J. Haney ◽  
Natalia L. Klyachko ◽  
Yuling Zhao ◽  
Alexander V. Kabanov ◽  
Elena V. Batrakova
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Extracellular Vesicles ◽  
Redox Enzyme ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Corrigendum to “Exosomes as drug delivery vehicles for Parkinson's disease therapy” [Journal of Controlled Release 207, (2015) 18–30]

2021 ◽  
Vol 339 ◽  
pp. 232-234
Author(s):  
Matthew J. Haney ◽  
Natalia L. Klyachko ◽  
Yuling Zhao ◽  
Richa Gupta ◽  
Evgeniya G. Plotnikova ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Controlled Release ◽  
Drug Delivery Vehicles ◽  
Disease Therapy ◽  
Delivery Vehicles

scholarly journals Exosomes as drug delivery vehicles for Parkinson's disease therapy

2015 ◽  
Vol 207 ◽  
pp. 18-30 ◽  
Author(s):  
Matthew J. Haney ◽  
Natalia L. Klyachko ◽  
Yuling Zhao ◽  
Richa Gupta ◽  
Evgeniya G. Plotnikova ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Drug Delivery Vehicles ◽  
Disease Therapy ◽  
Delivery Vehicles

Cancer therapy based on extracellular vesicles as drug delivery vehicles

2020 ◽  
Vol 327 ◽  
pp. 296-315 ◽  
Author(s):  
Laura Cabeza ◽  
Gloria Perazzoli ◽  
Mercedes Peña ◽  
Ana Cepero ◽  
Cristina Luque ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Extracellular Vesicles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Extracellular vesicles: Natural liver‐accumulating drug delivery vehicles for the treatment of liver diseases

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Gensheng Zhang ◽  
Xiaofang Huang ◽  
Huiqing Xiu ◽  
Yan Sun ◽  
Jiming Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Liver Diseases ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Extracellular Vesicles as Drug Delivery Vehicles for Rheumatoid Arthritis

2016 ◽  
Vol 11 (4) ◽  
pp. 329-342 ◽  
Author(s):  
Il-Kwon Kim ◽  
Sun-Hyun Kim ◽  
Seong-Mi Choi ◽  
Byung-Soo Youn ◽  
Han-Soo Kim
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Targeted Drug Delivery in Lipid-like Nanocages and Extracellular Vesicles

Acta Naturae ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 28-41 ◽  
Author(s):  
A. V. Sokolov ◽  
N. N. Kostin ◽  
L. A. Ovchinnikova ◽  
Y. A. Lomakin ◽  
A. A. Kudriaeva
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Structural Similarity ◽  
Biological Properties ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
High Level

The possibility of targeted drug delivery to a specific tissue, organ, or cell has opened new promising avenues in treatment development. The technology of targeted delivery aims to create multifunctional carriers that are capable of long circulation in the patients organism and possess low toxicity at the same time. The surface of modern synthetic carriers has high structural similarity to the cell membrane, which, when combined with additional modifications, also promotes the transfer of biological properties in order to penetrate physiological barriers effectively. Along with artificial nanocages, further efforts have recently been devoted to research into extracellular vesicles that could serve as natural drug delivery vehicles. This review provides a detailed description of targeted delivery systems that employ lipid and lipid-like nanocages, as well as extracellular vesicles with a high level of biocompatibility, highlighting genetically encoded drug delivery vehicles.

scholarly journals Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 388
Author(s):  
Renata Caroline Costa de Freitas ◽  
Rosario Dominguez Crespo Hirata ◽  
Mario Hiroyuki Hirata ◽  
Elena Aikawa
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Extracellular Vesicles ◽  
Biological Fluids ◽  
Long Distance ◽  
Drug Delivery Vehicles ◽  
Potential Biomarker ◽  
Delivery Vehicles

Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane and soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles), exosomes, and apoptotic bodies that can be released by various tissues into biological fluids. EV cargo can modulate physiological and pathological processes in recipient cells through near- and long-distance intercellular communication. Recent studies have shown that origin, amount, and internal cargos (nucleic acids, proteins, and lipids) of EVs are variable under different pathological conditions, including cardiovascular diseases (CVD). The early detection and management of CVD reduce premature morbidity and mortality. Circulating EVs have attracted great interest as a potential biomarker for diagnostics and follow-up of CVD. This review highlights the role of circulating EVs as biomarkers for diagnosis, prognosis, and therapeutic follow-up of CVD, and also for drug delivery. Despite the great potential of EVs as a tool to study the pathophysiology of CVD, further studies are needed to increase the spectrum of EV-associated applications.

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