Hepcidin protects grass carp (Ctenopharyngodon idellus) against Flavobacterium columnare infection via regulating iron distribution and immune gene expression

2018 ◽  
Vol 75 ◽  
pp. 274-283 ◽  
Author(s):  
Xiaolei Wei ◽  
V. Sarath Babu ◽  
Li Lin ◽  
Yazhen Hu ◽  
Yulei Zhang ◽  
...  
Aquaculture ◽  
2021 ◽  
Vol 541 ◽  
pp. 736762
Author(s):  
Zijun Lu ◽  
Ren Gao ◽  
Yafei Duan ◽  
Rui Han ◽  
Wenjie Guo ◽  
...  

Author(s):  
Ramasamy Harikrishnan ◽  
Gunapathy Devi ◽  
Chellam Balasundaram ◽  
Hien Van Doan ◽  
Sanchai Jaturasitha ◽  
...  

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ling Cai ◽  
Hongyu Liu ◽  
Fang Huang ◽  
Junya Fujimoto ◽  
Luc Girard ◽  
...  

AbstractSmall cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed “variant” due to the loss of NE characteristics. In this study, we computed NE scores for patient-derived SCLC cell lines and xenografts, as well as human tumors. We aligned NE properties with transcription factor-defined molecular subtypes. Then we investigated the different immune phenotypes associated with high and low NE scores. We found repression of immune response genes as a shared feature between classic SCLC and pulmonary neuroendocrine cells of the healthy lung. With loss of NE fate, variant SCLC tumors regain cell-autonomous immune gene expression and exhibit higher tumor-immune interactions. Pan-cancer analysis revealed this NE lineage-specific immune phenotype in other cancers. Additionally, we observed MHC I re-expression in SCLC upon development of chemoresistance. These findings may help guide the design of treatment regimens in SCLC.


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