The Y-chromosomal haplotype and haplogroup distribution of modern Switzerland still reflects the alpine divide as a geographical barrier for human migration

The Catholic Church is naturally associated with migrants and its history and doctrine areinextricably linked with the migration of people. Many of the documents of the Catholic Church referto the history of human migration. The responsibility of the Catholic Church for migrants has deephistorical and theological roots. The Catholic Church sees both the positive and the negative sidesof this phenomenon The pastoral care of migrants is a response to the needs of these people. It doesnot replace the territorial structures. They both work closely together and complement each other.The primary objective of the pastoral care of migrants is to enable migrants to integrate with thelocal community. An important element of these structures are religious orders of men and women.The most important thing for migrants is the Christian attitude of the local community tothem. Church repeatedly stressed the importance of hospitality to migrants. Both human andChristian attitude towards migrants expresses itself in a good reception, which is the main factorin overcoming the inevitable difficulties, preventing opposites and solving various problems. Thisattitude helps to alleviate the problems associated with the process of social integration.

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Environmental Stress and Human Migration in a Low-lying Developing Nation: A Comparison of Co-evolving Natural and Human Landscapes in the Physically and Culturally Diverse Context of Bangladesh

10.21236/ada598368 ◽

2013 ◽

Author(s):

Jr Goodbred ◽

Steven L.

Keyword(s):

Environmental Stress ◽

Culturally Diverse ◽

Human Migration ◽

Developing Nation ◽

Diverse Context

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Origin and formation of Yaponesians based on genome sequences

Impact ◽

10.21820/23987073.2020.7.56 ◽

2020 ◽

Vol 2020 (7) ◽

pp. 56-58

Author(s):

Naruya Saitou

Keyword(s):

Population Genetics ◽

Human Migration ◽

Human Populations ◽

Genome Sequences ◽

Japanese Archipelago ◽

Broad Term ◽

The Japanese Archipelago ◽

Ebb And Flow ◽

National Institute Of Genetics

The ebb and flow of human migration across the planet can nowadays be probed with advanced archaeology, linguistics, anthropology and genomics. Together, these can provide a convincing picture of the various divergences and convergences of different human populations across vast areas. It is now possible to better understand how, why and where a particular group or society arose. Professor Naruya Saitou of the Population Genetics Laboratory at the National Institute of Genetics in Mishima has dedicated his career to the synthesis of these disciplines. The current focus of his research is on understanding the origins and formation of the Yaponesian people. This broad term was coined by writer Toshio Shimao in 1960s to encompass the diverse peoples of the Japanese Archipelago over its many thousands of years of inhabitation. Saitou's research is helping to uncover Japan's ancient past.

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Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

Nature Communications ◽

10.1038/s41467-021-22821-w ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Mary Elizabeth Mathyer ◽

Erin A. Brettmann ◽

Alina D. Schmidt ◽

Zane A. Goodwin ◽

Inez Y. Oh ◽

...

Keyword(s):

Selective Sweep ◽

Skin Barrier ◽

Human Migration ◽

Epidermal Differentiation ◽

Human Populations ◽

Epidermal Differentiation Complex ◽

Regulatory Module ◽

Reporter Assays ◽

Out Of Africa

AbstractThe genetic modules that contribute to human evolution are poorly understood. Here we investigate positive selection in the Epidermal Differentiation Complex locus for skin barrier adaptation in diverse HapMap human populations (CEU, JPT/CHB, and YRI). Using Composite of Multiple Signals and iSAFE, we identify selective sweeps for LCE1A-SMCP and involucrin (IVL) haplotypes associated with human migration out-of-Africa, reaching near fixation in European populations. CEU-IVL is associated with increased IVL expression and a known epidermis-specific enhancer. CRISPR/Cas9 deletion of the orthologous mouse enhancer in vivo reveals a functional requirement for the enhancer to regulate Ivl expression in cis. Reporter assays confirm increased regulatory and additive enhancer effects of CEU-specific polymorphisms identified at predicted IRF1 and NFIC binding sites in the IVL enhancer (rs4845327) and its promoter (rs1854779). Together, our results identify a selective sweep for a cis regulatory module for CEU-IVL, highlighting human skin barrier evolution for increased IVL expression out-of-Africa.

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Correction to: Human migration: the big data perspective

International Journal of Data Science and Analytics ◽

10.1007/s41060-021-00260-6 ◽

2021 ◽

Author(s):

Alina Sîrbu ◽

Gennady Andrienko ◽

Natalia Andrienko ◽

Chiara Boldrini ◽

Marco Conti ◽

...

Keyword(s):

Big Data ◽

Human Migration

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The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction–diffusion system

Scientific Reports ◽

10.1038/s41598-021-84653-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Keiichi Kataoka ◽

Hironori Fujita ◽

Mutsumi Isa ◽

Shimpei Gotoh ◽

Akira Arasaki ◽

...

Keyword(s):

Molecular Mechanisms ◽

Computational Study ◽

Reaction Diffusion ◽

Human Migration ◽

Reaction Diffusion System ◽

Diffusion System ◽

Tooth Root ◽

Computed Tomography Images ◽

Diffusion Dynamics ◽

Root Morphogenesis

AbstractMorphological variations in human teeth have long been recognized and, in particular, the spatial and temporal distribution of two patterns of dental features in Asia, i.e., Sinodonty and Sundadonty, have contributed to our understanding of the human migration history. However, the molecular mechanisms underlying such dental variations have not yet been completely elucidated. Recent studies have clarified that a nonsynonymous variant in the ectodysplasin A receptor gene (EDAR370V/A; rs3827760) contributes to crown traits related to Sinodonty. In this study, we examined the association between theEDARpolymorphism and tooth root traits by using computed tomography images and identified that the effects of theEDARvariant on the number and shape of roots differed depending on the tooth type. In addition, to better understand tooth root morphogenesis, a computational analysis for patterns of tooth roots was performed, assuming a reaction–diffusion system. The computational study suggested that the complicated effects of theEDARpolymorphism could be explained when it is considered that EDAR modifies the syntheses of multiple related molecules working in the reaction–diffusion dynamics. In this study, we shed light on the molecular mechanisms of tooth root morphogenesis, which are less understood in comparison to those of tooth crown morphogenesis.

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