scholarly journals COVID-ONE-hi: The One-stop Database for COVID-19 Specific Humoral Immunity and Clinical Parameters

Author(s):  
Zhaowei Xu ◽  
Yang Li ◽  
Qing Lei ◽  
Likun Huang ◽  
Dan-yun Lai ◽  
...  
2021 ◽  
Author(s):  
Zhaowei Xu ◽  
Yang Li ◽  
Qing Lei ◽  
Likun Huang ◽  
Dan-yun Lai ◽  
...  

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, differences in immune responses and clinical features among COVID-19 patients remain largely unknown. Here, we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters (COVID-ONE humoral immune). COVID-ONE humoral immunity is based on a dataset that contains the IgG/IgM responses to 21 of 28 known SARS-CoV-2 proteins and 197 spike protein peptides against 2,360 COVID-19 samples collected from 783 patients. In addition, 96 clinical parameters for the 2,360 samples and information for the 783 patients are integrated into the database. Furthermore, COVID-ONE humoral immune provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups. A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters. After the START button is clicked, one can readily obtain a comprehensive analysis report for further interpretation. COVID-ONE-humoral immune is freely available at www.COVID-ONE.cn.


2021 ◽  
Author(s):  
Zhaowei Xu ◽  
Yang Li ◽  
Qing Lei ◽  
Likun Huang ◽  
Dan-yun Lai ◽  
...  

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, differences in immune responses and clinical features among COVID-19 patients remain largely unknown. Here, we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters (COVID-ONE humoral immune). COVID-ONE humoral immunity is based on a dataset that contains the IgG/IgM responses to 21 of 28 known SARS-CoV-2 proteins and 197 spike protein peptides against 2,360 COVID-19 samples collected from 783 patients. In addition, 96 clinical parameters for the 2,360 samples and information for the 783 patients are integrated into the database. Furthermore, COVID-ONE humoral immune provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups. A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters. After the START button is clicked, one can readily obtain a comprehensive analysis report for further interpretation. COVID-ONE-humoral immune is freely available at www.COVID-ONE.cn.


2021 ◽  
pp. 102111
Author(s):  
Ryan Alexander Hickmott ◽  
Abdulhameed Bosakhar ◽  
Sebastian Quezada Rojas ◽  
Mikaela Barresi ◽  
David Walker ◽  
...  
Keyword(s):  
One Stop ◽  

Quaerendo ◽  
2000 ◽  
Vol 30 (3) ◽  
pp. 240-249
Author(s):  
Marieke Van Delft ◽  
Marco De Niet

2002 ◽  
Vol 124 (4) ◽  
pp. 537-544 ◽  
Author(s):  
Gong Cheng ◽  
Jean W. Zu

In this paper, a mass-spring-friction oscillator subjected to two harmonic disturbing forces with different frequencies is studied for the first time. The friction in the system has combined Coulomb dry friction and viscous damping. Two kinds of steady-state vibrations of the system—non-stop and one-stop motions—are considered. The existence conditions for each steady-state motion are provided. Using analytical analysis, the steady-state responses are derived for the two-frequency oscillating system undergoing both the non-stop and one-stop motions. The focus of the paper is to study the influence of the Coulomb dry friction in combination with the two frequency excitations on the dynamic behavior of the system. From the numerical simulations, it is found that near the resonance, the dynamic response due to the two-frequency excitation demonstrates characteristics significantly different from those due to a single frequency excitation. Furthermore, the one-stop motion demonstrates peculiar characteristics, different from those in the non-stop motion.


2013 ◽  
Vol 12 (1) ◽  
pp. e367
Author(s):  
J.S. Phull ◽  
A.C. Carter ◽  
J.D. Osborne ◽  
T. Lloyd ◽  
S. Sloan ◽  
...  
Keyword(s):  
One Stop ◽  

2020 ◽  
Vol 10 (2) ◽  
pp. 381
Author(s):  
Mary Ismowati ◽  
Ahmad Hidayat Rahadian ◽  
Muhammad Ali Massyhury ◽  
Muhammad Rafi Suryadi

The aim of the study was to obtain a formulation of the implementation of the One-Stop Services Policy (PTSP) in the North Jakarta Administrative City, namely the implementation of Perda No. 12 of 2013, and the Implementation of Presidential Regulation No. 91 of 2017 concerning the acceleration of ease of doing business through the implementation of an information technology-based licensing system (OSS). The research method used a qualitative approach by conducting interviews with a number of informants to determine the conditions and phenomena of the implementation of PTSP policies in North Jakarta. The research involved two research members from students in the framework of thesis research. The results of the research show that implementers have understood their duties and functions, but in the smooth running of their duties, they are constrained by a lack of human resources both in quantity and quality, support for information technology equipment that is not up to date, including the availability of information technology personnel at the district and sub-district levels. Then the OSS policy according to PP No. 24/2018 has not been fully effective, because it has not been fully integrated with the existing licensing system in PM-PTSP DKI Jakarta, namely JakEVO. The main obstacle to policy implementation, namely in terms of human resources, employee status has not been transferred to functional positions so that it affects career ranks and motivation. In addition, there is no HR competency standard for services, for online system services are not implemented according to target. The solution to overcome the obstacles conceptually has not been done.


2013 ◽  
Vol 9 (3) ◽  
pp. 74-95 ◽  
Author(s):  
Thomas Kohlborn ◽  
Erwin Fielt ◽  
Maximillian Boentgen

E-government is seen as a promising approach for governments to improve their service towards citizens and become more cost-efficient in service delivery. This is often combined with one-stop government, which is a citizen-oriented approach stressing integrated provision of services from multiple departments via a single access point, the one-stop government portal. While the portal concept is gaining prominence in practice, there is little known about its status in academic literature. This hinders academics in building an accumulated body of knowledge around the concept and makes it hard for practitioners to access relevant academic insights on the topic. The objective of this study is to identify and understand the key themes of the one-stop government portal concept in academic, e-government research. A holistic analysis is provided by addressing different viewpoints: social-political, legal, organizational, user, security, service, data and information, and technical. As an overall finding, the authors conclude that there are two different approaches: a more pragmatic approach focuses on quick wins in particular related to usability and navigation and a more ambitious, transformational approach having far reaching social-political, legal, and organizational implications.


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