scholarly journals Structural, biological and pharmaceutical importance of antibiotic agent chloramphenicol

Heliyon ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e03433
Author(s):  
A. Sathya ◽  
T. Prabhu ◽  
S. Ramalingam
Keyword(s):  
Antibiotic Agent

scholarly journals Engineering of Streptoalloteichus tenebrarius 2444 for Sustainable Production of Tobramycin

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4343
Author(s):  
Lena Mitousis ◽  
Hannes Maier ◽  
Luka Martinovic ◽  
Andreas Kulik ◽  
Sigrid Stockert ◽  
...  
Keyword(s):  
Aminoglycoside Antibiotic ◽  
Biosynthetic Gene Cluster ◽  
Genetically Engineered ◽  
Sustainable Production ◽  
Biosynthetic Gene ◽  
Strain Development ◽  
Antibiotic Agent ◽  
Phenotypic Stability ◽  
High Concentrations ◽  
Hydrolysis Of

Tobramycin is a broad-spectrum aminoglycoside antibiotic agent. The compound is obtained from the base-catalyzed hydrolysis of carbamoyltobramycin (CTB), which is naturally produced by the actinomycete Streptoalloteichus tenebrarius. However, the strain uses the same precursors to synthesize several structurally related aminoglycosides. Consequently, the production yields of tobramycin are low, and the compound’s purification is very challenging, costly, and time-consuming. In this study, the production of the main undesired product, apramycin, in the industrial isolate Streptoalloteichus tenebrarius 2444 was decreased by applying the fermentation media M10 and M11, which contained high concentrations of starch and dextrin. Furthermore, the strain was genetically engineered by the inactivation of the aprK gene (∆aprK), resulting in the abolishment of apramycin biosynthesis. In the next step of strain development, an additional copy of the tobramycin biosynthetic gene cluster (BGC) was introduced into the ∆aprK mutant. Fermentation by the engineered strain (∆aprK_1-17L) in M11 medium resulted in a 3- to 4-fold higher production than fermentation by the precursor strain (∆aprK). The phenotypic stability of the mutant without selection pressure was validated. The use of the engineered S. tenebrarius 2444 facilitates a step-saving, efficient, and, thus, more sustainable production of the valuable compound tobramycin on an industrial scale.

The Antibiotic Agent from Marasmius ramealis

Nature ◽  
1948 ◽  
Vol 162 (4106) ◽  
pp. 61-62 ◽  
Author(s):  
GERD BENDZ ◽  
GÖSTA WALLMARK ◽  
KARIN ÖBLOM
Keyword(s):  
Antibiotic Agent

A STAINING TECHNIQUE FOR EVALUATING THE TOXICITY OF AN ANTIBIOTIC SUBSTANCE OF MICROBIOLOGICAL ORIGIN

1942 ◽  
Vol 20c (12) ◽  
pp. 602-608
Author(s):  
H. Katznelson
Keyword(s):  
Schizosaccharomyces Pombe ◽  
Staining Technique ◽  
Neutral Red ◽  
Antibiotic Agent ◽  
Antibiotic Substance

A method is described in which the absorption of neutral red by dead cells of Schizosaccharomyces pombe is used as an index of the toxicity of an antibiotic agent produced by a bacillus.

Daptomycin for Methicillin-Resistant Staphylococcus aureus Diabetic Foot Infections

2014 ◽  
Vol 104 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Warren S. Joseph ◽  
Thomas Quast ◽  
Alberto Cogo ◽  
Monica G. Crompton ◽  
Min Jung Yoon ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Diabetic Foot ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Success ◽  
Initial Therapy ◽  
Antibiotic Agent ◽  
Negative Effects ◽  
Methicillin Resistant ◽  
Diabetic Foot Infections ◽  
Antibiotic Drug

Background Diabetic foot infection (DFI) is a serious, difficult-to-treat infection, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin has been the standard treatment for MRSA infection, but lower response rates in MRSA skin infections have been reported. This analysis assessed the outcome and safety of daptomycin therapy in patients with a DFI caused by MRSA. Methods Using the Cubicin Outcomes Registry and Experience and the European Cubicin Outcomes Registry and Experience (2006–2009), 79 patients with MRSA DFI were identified and included in this analysis. Results In the 74 evaluable patients, daptomycin was administered at a median dose of 4.8 mg/kg primarily every 24 hours (85.1%) and for a median of 15.0 days. Overall, 77.0% of the patients (57 of 74) received initial therapy with activity against MRSA; however, of patients receiving daptomycin as second-line therapy (n = 31), only 45.2% were treated with an antibiotic agent active against MRSA. The overall clinical success and treatment failure rates were 89.2% and 10.8%, respectively. Success with daptomycin therapy was higher in patients who had surgery and in those whose initial therapy was daptomycin. Eleven patients had 14 adverse events, two of which were possibly related to daptomycin use and led to discontinuation. Conclusions In a large real-world cohort of patients with MRSA DFI, daptomycin therapy was shown to be generally well tolerated and effective. The use of an anti-MRSA antibiotic agent should be considered when implementing first-line antibiotic drug therapy for DFI in countries where MRSA is common to avoid inappropriate empirical treatment and potential negative effects on outcomes.

scholarly journals Biotransformation of the antibiotic agent cephadroxyl and the synthetic dye Reactive Black 5 by Leptosphaerulina sp. immobilised on Luffa (Luffa cylindrica) sponge

2019 ◽  
Vol 18 ◽  
pp. 101051 ◽  
Author(s):  
María Susana Pérez-Grisales ◽  
Marian Castrillón-Tobón ◽  
Ledys S. Copete-Pertuz ◽  
Jersson Plácido ◽  
Amanda L. Mora-Martínez
Keyword(s):  
Reactive Black 5 ◽  
Luffa Cylindrica ◽  
Antibiotic Agent ◽  
Synthetic Dye

scholarly journals Antibacterial Application on Staphylococcus aureus Using Antibiotic Agent/Zinc Oxide Nanorod Arrays/Polyethylethylketone Composite Samples

Nanomaterials ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 713
Author(s):  
Dave W. Chen ◽  
Kuan-Yi Lee ◽  
Min-Hua Tsai ◽  
Tung-Yi Lin ◽  
Chien-Hao Chen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Zinc Oxide ◽  
Synthesis Method ◽  
Antibacterial Properties ◽  
Precursor Solution ◽  
Zno Nanorod ◽  
Nanorod Arrays ◽  
Zno Nanorod Arrays ◽  
Antibiotic Agent ◽  
Buffer Solution

In this study, zinc oxide (ZnO) nanorod arrays as antibiotic agent carriers were grown on polyetheretherketone (PEEK) substrates using a chemical synthesis method. With the concentration of ammonium hydroxide in the precursor solution kept at 4 M, ZnO nanorod arrays with diameters in the range of 100–400 nm and a loading density of 1.7 mg/cm2 were grown onto the PEEK substrates. Their drug release profiles and the antibacterial properties of the antibiotic agent/ZnO/PEEK samples in the buffer solution were investigated. The results showed that the concentrations of antibiotic agents (ampicillin or vancomycin) released from the samples into the buffer solution were higher than the value of minimum inhibitory concentration of 90% for Staphylococcus aureus within the 96 h test. The bioactivities of ampicillin and vancomycin on substrates also showed around 40% and 80% on the Staphylococcus aureus, respectively. In the antibacterial activity test, sample with the suitable loading amount of antibiotic agent had a good inhibitory effect on the growth of Staphylococcus aureus.

scholarly journals Complete Genome Sequence of the Corallopyronin A-Producing Myxobacterium Corallococcus coralloides B035

2019 ◽  
Vol 8 (17) ◽  
Author(s):  
Sarah Bouhired ◽  
Oliver Rupp ◽  
Jochen Blom ◽  
Till F. Schäberle ◽  
Andrea Schiefer ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Antibiotic Agent ◽  
Preclinical Development ◽  
Content Type ◽  
Genetic Level

Myxobacteria are a source of unique metabolites, including corallopyronin A (CorA), a promising antibiotic agent in preclinical development for the treatment of filariasis. To investigate the production of CorA on the genetic level, we present the complete 9.6-Mb genome sequence of the CorA producer Corallococcus coralloides B035.

Copper(i) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode

2016 ◽  
Vol 45 (12) ◽  
pp. 5052-5063 ◽  
Author(s):  
U. K. Komarnicka ◽  
R. Starosta ◽  
M. Płotek ◽  
R. F. M. de Almeida ◽  
M. Jeżowska-Bojczuk ◽  
...  
Keyword(s):  
Cytotoxic Action ◽  
Antibiotic Agent ◽  
Action Mode ◽  
Thiocyanate Complexes ◽  
Fluoroquinolone Antibiotic ◽  
Insight Into

A first insight into the cytotoxic action mode of copper(i) iodide or copper(i) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rdgeneration fluoroquinolone antibiotic agent) and 2,9-dimethyl-1,10-phenanthroline or 2,2′-biquinoline as auxiliary ligands.

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