scholarly journals Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats

Heliyon ◽  
2022 ◽  
pp. e08771
Author(s):  
Md. Mynul Hassan ◽  
Shihab Uddin ◽  
Amrita Bhowmik ◽  
Ayesha Ashraf ◽  
Md. Mahmodul Islam ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Phytochemical Screening ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects ◽  
Fruit Rind

Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia

RSC Advances ◽  
2016 ◽  
Vol 6 (15) ◽  
pp. 12235-12242 ◽  
Author(s):  
Yi Shao ◽  
Yao Yu ◽  
Cheng Li ◽  
Jing Yu ◽  
Rongrong Zong ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Diabetic Rats ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Ginger and quercetin have been reported to have significant antidiabetic effects.

Antidiabetic effects of polysaccharide from azuki bean (Vigna angularis) in type 2 diabetic rats via insulin/PI3K/AKT signaling pathway

2020 ◽  
Vol 101 ◽  
pp. 105456 ◽  
Author(s):  
Guangjie Wu ◽  
Zhouya Bai ◽  
Yujun Wan ◽  
Huifang Shi ◽  
Xiaojun Huang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Akt Signaling ◽  
Diabetic Rats ◽  
Azuki Bean ◽  
Akt Signaling Pathway ◽  
Vigna Angularis ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin

2013 ◽  
Vol 145 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Zhi Liu ◽  
Wei Li ◽  
Xiang Li ◽  
Ming Zhang ◽  
Li Chen ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Molecular Mechanism Underlying the Antidiabetic Effects of a Siddha Polyherbal Preparation in the Liver of Type 2 Diabetic Adult Male Rats

2012 ◽  
Vol 18 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Venkataraman Balaji ◽  
Jayaraman Selvaraj ◽  
Sampath Sathish ◽  
Chinnaiyan Mayilvanan ◽  
Karundevi Balasubramanian
Keyword(s):  
Insulin Receptor ◽  
Molecular Mechanism ◽  
Diabetic Rats ◽  
Male Rats ◽  
Tinospora Cordifolia ◽  
Syzygium Aromaticum ◽  
Mrna Levels ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

A siddha polyherbal preparation consisting of 5 medicinal plants, namely, Asparagus racemosus, Emblica officinalis, Salacia oblonga, Syzygium aromaticum, and Tinospora cordifolia, in equal ratio, was formulated to examine the molecular mechanism by which it exhibits antidiabetic effects in the liver of high-fat and fructose-induced type 2 diabetic rats. The polyherbal preparation treated type 2 diabetic rats showed an increase in insulin receptor, Akt, and glucose transporter2 mRNA levels compared with diabetic rats. Insulin receptor, insulin receptor substrate-2, Akt, phosphorylated Akt substrate of 160kDaThreonine642, α-Actinin-4, β-arrestin-2, and glucose transporter2 proteins were also markedly decreased in diabetic rats, whereas the polyherbal preparation treatment significantly improved the expression of these proteins more than that of metformin-treated diabetic rats. The expression pattern of insulin signaling molecules analyzed in the present study signifies the therapeutic efficacy of the siddha polyherbal preparation.

Antidiabetic effects ofEmbelia ribesextract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats

2013 ◽  
Vol 7 (3-4) ◽  
pp. 186-196 ◽  
Author(s):  
Uma Bhandari ◽  
Hemantkumar Somabhai Chaudhari ◽  
Geetika Khanna ◽  
Abul Kalam Najmi
Keyword(s):  
High Fat Diet ◽  
Low Dose ◽  
Diabetic Rats ◽  
High Fat ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Antidiabetic effects of Artemisia sphaerocephala Krasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats

2009 ◽  
Vol 125 (3) ◽  
pp. 410-416 ◽  
Author(s):  
Xiao-Hui Xing ◽  
Zheng-Mao Zhang ◽  
Xin-Zhong Hu ◽  
Rui-Qin Wu ◽  
Chao Xu
Keyword(s):  
Diabetic Rats ◽  
Food Additive ◽  
Novel Food ◽  
Artemisia Sphaerocephala ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Antidiabetic Effects of Total Flavonoids from Litsea Coreana leve on Fat-Fed, Streptozotocin-Induced Type 2 Diabetic Rats

2010 ◽  
Vol 38 (04) ◽  
pp. 713-725 ◽  
Author(s):  
Yun-Xia Lu ◽  
Qiu Zhang ◽  
Jun Li ◽  
Yu-Xiu Sun ◽  
Ling-Yun Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Diabetic Rats ◽  
Control Group ◽  
Chow Diet ◽  
Total Flavonoids ◽  
Alcohol Extract ◽  
Oxidation Stress ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

This study was initiated to determine the possible antidiabetic effects of total flavonoids of Litsea Coreana leve (TFLC), an alcohol extract from the dried leaves of Litsea Coreana leve, on type 2 diabetic rats. Male Sprague-Dawley rats ( n = 40, 160–180 g) were divided into two groups and fed with normal chow diet (Normal Control group) or high-fat diet (HFD) for a period of 4 weeks. After 4 weeks of dietary manipulation, the HFD-fed rats were injected with 30 mg/kg streptozocin (STZ) to induce diabetes 72 hours after STZ injection. These diabetic rats were randomly divided into 3 groups ( n = 10): Diabetic Control group, Diabetic + TFLC group and Diabetic + PIO group. Diabetic + TFLC group and Diabetic + PIO group were orally administered with 400 mg/kg TFLC or 10 mg/kg pioglitazone (all suspended in 0.5% CMC-Na) respectively for 6 weeks. All rats were examined for body weight, serum and hepatic biochemical indices, content of malondialdehyde (MDA), activities of superoxide dismutase (SOD) and pathological changes in liver and pancreas, as well as protein tyrosine phosphatase 1B (PTP1B) expression in liver. The diabetic rats became obese, insulin resistant, hyperglycemic and hyperlipidemic. Treatment with TFLC showed a significant increase in insulin sensitivity, serum HDL-C level and SOD activities, meanwhile marked decrease in body weight, serum FFA, TC, TG, LDL-C, CRP, MDA content. TFLC also attenuated pathologic alterations in liver and pancreatic islet. Furthermore, TFLC was found to decrease the expression of PTP1B in diabetic rat liver. These results suggested that TFLC could ameliorate hyperglycemia, hyperlipoidemia, inflammation and oxidation stress, as well as insulin resistance of type 2 diabetic rats.

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