Effects of natural herb-containing dental toothpaste on periodontal pathogenic bacteria and clinical parameters: a randomized clinical trial

Purpose: The objective of this prospective randomized clinical trial (RCT) was to analyze and compare the clinical behavior of three types of prosthesis supported by single implants in the posterior region after three years of functional loading. Materials and methods: Seventy-five implants were divided into three groups according to the type of prosthetic restoration: screw-retained crown (group GS); cemented crown without finishing line (biologically oriented preparation technique) (group GBOPT); and conventional cemented crown with finishing line (group GCC). After three years in function, clinical parameters (presence of keratinized mucosa, probing depths, bleeding on probing, and radiographic bone loss) were compared between the three experimental groups. The possible correlation between soft tissue clinical parameters and bone loss was also analyzed. Results: Statistical analysis found significant differences in clinical parameters between the different types of crown, with the cemented restoration without finishing line (BOPT) presenting fewer complications and better peri-implant health outcomes including: significantly different KMW data (mm), with significant differences between groups GBOPT and GCC (p < 0.001, Kruskal–Wallis test), with GBOPT obtaining larger quantities of keratinized mucosa (KM); statistically significant differences in probing depth (PD) values between groups GBOPT and GCC (p = 0.010, Kruskal–Wallis test); significant differences in bleeding on probing (BOP) between groups GBOPT and GCC (p = 0.018, Chi2 test) in favor of GBOPT. Conclusions: Soft tissue behavior around implants is related to the type of prosthetic restoration used, with cemented prostheses with BOPT presenting better peri-implant soft tissue behavior.

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Assessment of the Effect of Photodynamic Therapy on Treatment of Moderate-to-Severe Periodontitis; a Randomized Clinical Trial Study

Global Journal of Health Science ◽

10.5539/gjhs.v9n4p83 ◽

2016 ◽

Vol 9 (4) ◽

pp. 83

Author(s):

Babak Amoian ◽

Aida Mirzaee ◽

Seyed Mostafa Hosseini

Keyword(s):

Clinical Trial ◽

Photodynamic Therapy ◽

Randomized Clinical Trial ◽

Chronic Periodontitis ◽

Time Interval ◽

Clinical Parameters ◽

Scaling And Root Planing ◽

Bleeding On Probing ◽

Treatment Groups ◽

Root Planing

BACKGROUND & AIM: Photodynamic therapy is a localized non-invasive treatment modality for the periodontal disease. Some evidences have shown that this technique is effective in improving the treatment outcome. This study compared the effects of photodynamic therapy with and without scaling and root planing and scaling and root planing alone on the clinical parameters of the chronic periodontitis.MATERIALS & METHODS: In this single-blind, randomized clinical trial, 30 chronic periodontitis patients (10 for each modality) were selected and three different methods; photodynamic therapy alone (Group1) by FotoSan 630 system, scaling and root planning (SRP) alone (Group2), scaling and root planing combined with photodynamic therapy (Group3) were done for them randomly. Clinical parameters of probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level (CAL) were measured at the baseline and 3, 6 and 12 weeks later. One-sided analysis of variance test was used to analyze PPD and CAL among the treatment groups in each time interval while the paired comparisons were carried out by employment of Dunnett’s test. The treatment groups were statically analyzed by the chi-square test regarding BOP. RESULTS: Before the treatment; no significant differences observed among treatment modalities regarding clinical parameters; while the differences were significant at three weeks (p<0.0001 for PPD and CAL; p<0.001 for BOP); six weeks (p<0.0001 for PPD and CAL, p<0.002 for BOP); and 12 weeks after the treatment (all: p<0.0001). The least PPD and CAL values and the most frequency of non-bleeding on probing status were measured for PDT+SRP modality at three, six, and twelve weeks after the treatment.CONCLUSION: Photodynamic therapy supported the clinical parameters of periodontitis similar to SRP; however, PDT combined with SRP demonstrated a better result than that of SRP alone. Therefore, PDT combined with SRP can be used to improve outcomes of clinical parameters of periodontitis as compared to SRP alone in the short-term.

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Clinical and Microbiological Efficacy of Pyrophosphate Containing Toothpaste: A Double-Blinded Placebo-Controlled Randomized Clinical Trial

Microorganisms ◽

10.3390/microorganisms8111806 ◽

2020 ◽

Vol 8 (11) ◽

pp. 1806

Author(s):

Inpyo Hong ◽

Hyun Gee Lee ◽

Hye Lim Keum ◽

Myong Ji Kim ◽

Ui-Won Jung ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Pathogenic Bacteria ◽

Test Group ◽

Amplicon Sequencing ◽

Oral Microbiome ◽

Plaque Index ◽

Control Group ◽

Placebo Control ◽

Significant Difference

(1) Background: Dental calculus works as a niche wherein pathogenic bacteria proliferate in the oral cavity. Previous studies revealed the anticalculus activity of pyrophosphates, however there was no clinical study that evaluated microbiome changes associated with calculus inhibition. Therefore, the aim of this randomized clinical trial was to evaluate the calculus inhibition of pyrophosphate-containing toothpaste and its effect on oral microbiome changes. (2) Methods: Eighty subjects with a calculus index ≥2 on the lingual of the mandibular anterior tooth were randomly allocated to the test group that pyrophosphate-containing toothpaste was given to or the placebo control group. Full mouth debridement and standardized tooth brushing instruction were given before the allocation. Plaque index, gingival index, calculus index, probing depth, and bleeding on probing were measured at the baseline, and at 4, 8 and 12 weeks. Genomic DNA was extracted from the plaque samples collected at the baseline and at 12 weeks, and 16S ribosomal RNA gene amplicon sequencing was applied for microbiome analysis. (3) Results: None of the clinical parameters showed significant differences by visits or groups, except the plaque index of the test group, which reduced significantly between 4 and 12 weeks. A significant difference of microbiome between the baseline and 12 weeks was observed in the test group. Between baseline and 12 weeks, the proportion of Spirochetes decreased in the control group, and the proportions of Proteobacteria, Fusobacteria and Spirochetes in the phylum level and the proportions of Haemophilus, Fusobacterium and Capnocytophaga in the genus level decreased in the test group. In the test group, as plaque index decreased, Streptococcus increased, and Fusobacterium and Haemophilus parainfluenza decreased. (4) Conclusion: The use of pyrophosphate-containing toothpaste effectively inhibited the dysbiosis of the oral microbiome and the proliferation of pathogenic species in periodontal disease. Clinically, plaque formation in the pyrophosphate-containing toothpaste group was effectively decreased, however there was no significant change in calculus deposition.

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Evaluation of several clinical parameters after bleaching with hydrogen peroxide at different concentrations: A randomized clinical trial

Journal of Dentistry ◽

10.1016/j.jdent.2017.11.008 ◽

2018 ◽

Vol 68 ◽

pp. 91-97 ◽

Cited By ~ 8

Author(s):

Suellen Nogueira Linares Lima ◽

Izabella Santos Ribeiro ◽

Marcos Augusto Grisotto ◽

Elizabeth Soares Fernandes ◽

Viviane Hass ◽

...

Keyword(s):

Clinical Trial ◽

Hydrogen Peroxide ◽

Randomized Clinical Trial ◽

Clinical Parameters

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Effect of Non Surgical Periodontal Therapy on Salivary Ph in Periodontal Disease: A Randomized Clinical Trial

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i21b31374 ◽

2021 ◽

pp. 12-17

Author(s):

Stuti Gupta ◽

. Shradha ◽

Ejya Sharma ◽

Himani Sharma ◽

Saransh Srivastava ◽

...

Keyword(s):

Clinical Trial ◽

Sample Size ◽

Randomized Clinical Trial ◽

Periodontal Therapy ◽

Statistical Testing ◽

Research Centre ◽

Clinical Parameters ◽

College Hospital ◽

Significant Difference ◽

Salivary Ph

The aim of the study is to assess the effect of pre and post Non Surgical Periodontal Therapy on Salivary pH in patients suffering with Chronic Periodontits. Patients reporting to the Department of Periodontics, I.T.S Dental College, Hospital & Research Centre, Greater Noida, Uttar Pradesh are included in the study. It is a randomized clinical trial where patients are randomized into two groups of Generalized Chronic Gingivitis and Generalized Chronic Periodontitis. The study are performed with the Sample size of 30 patients and 2 months Period were included. Unstimulated Saliva is collected at the first visit when patient reports to the OPD for NSPT. Clinical Parameters are recorded and NSPT is performed for the patient. Post 14 days of the treatment, saliva is collected and analysed for pH and clinical parameters are recorded again. pH is determined using a pH meter. Data is collected and statistically interpreted. The statistical testing to be used in this study are Mann Whitney U Test, Chi- square test and Paired t-test. There was statistically significant difference in plaque index, gingival index and oral hygiene index between two groups. There was a definite reduction in pH post SRP but it was statistically non significant due to relatively smaller sample size. Further research is required to substantiate the results for the same.

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