The TyG Index as a Marker of Subclinical Atherosclerosis and Arterial Stiffness in Lean and Overweight Postmenopausal Women

Abstract Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness. Methods A total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness. Results Multivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29–48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17–0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25–2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose–response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005). Conclusion Participants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.

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The metabolic syndrome is associated with carotid atherosclerosis and arterial stiffness in asymptomatic, nondiabetic postmenopausal women

Gynecological Endocrinology ◽

10.1080/09513590.2017.1344208 ◽

2017 ◽

Vol 34 (1) ◽

pp. 78-82 ◽

Cited By ~ 10

Author(s):

Irene Lambrinoudaki ◽

Aikaterini Kazani ◽

Eleni Armeni ◽

Demetrios Rizos ◽

Areti Augoulea ◽

...

Keyword(s):

Metabolic Syndrome ◽

Arterial Stiffness ◽

Postmenopausal Women ◽

Carotid Atherosclerosis ◽

The Metabolic Syndrome

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Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive

BMC Cardiovascular Disorders ◽

10.1186/1471-2261-12-3 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 74

Author(s):

Jose I Recio-Rodriguez ◽

◽

Manuel A Gomez-Marcos ◽

Maria C Patino-Alonso ◽

Cristina Agudo-Conde ◽

...

Keyword(s):

Arterial Stiffness ◽

Abdominal Obesity ◽

Wave Reflection ◽

Subclinical Atherosclerosis ◽

General Obesity

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Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

10.21203/rs.3.rs-31909/v2 ◽

2020 ◽

Author(s):

Minghui Li ◽

Aihua Zhan ◽

Xiao Huang ◽

Lihua Hu ◽

Wei Zhou ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Fasting Glucose ◽

Independent Predictor ◽

Positive Association ◽

Regression Analyses ◽

Registry Study ◽

Hypertensive Patients ◽

Tyg Index ◽

Triglyceride Glucose Index

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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Effects of Diet and/or Low-Intensity Resistance Exercise Training on Arterial Stiffness, Adiposity, and Lean Mass in Obese Postmenopausal Women

American Journal of Hypertension ◽

10.1093/ajh/hps050 ◽

2013 ◽

Vol 26 (3) ◽

pp. 416-423 ◽

Cited By ~ 42

Author(s):

A. Figueroa ◽

F. Vicil ◽

M. A. Sanchez-Gonzalez ◽

A. Wong ◽

M. J. Ormsbee ◽

...

Keyword(s):

Exercise Training ◽

Arterial Stiffness ◽

Resistance Exercise ◽

Postmenopausal Women ◽

Lean Mass ◽

Resistance Exercise Training ◽

Low Intensity

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Parameters of arterial stiffness in hypertensive patients with and without subclinical carotid atherosclerosis

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2021-27-4-427-435 ◽

2021 ◽

Vol 27 (4) ◽

pp. 427-435

Author(s):

V. E. Gumerova ◽

S. A. Sayganov ◽

V. V. Gomonova

Keyword(s):

Arterial Stiffness ◽

Pulse Pressure ◽

Augmentation Index ◽

Subclinical Atherosclerosis ◽

Stiffness Index ◽

Control Group ◽

Hypertensive Patients ◽

Significant Difference ◽

Arterial Stiffness Index ◽

Plaque Detection

Objective. To assess the relationship between arterial stiffness parameters in hypertensive patients with and without atherosclerotic lesions.Design and methods. We included 127 subjects who were divided into 3 groups: patients with hypertension (HTN) without atherosclerosis (n = 42); patients with HTN and subclinical atherosclerosis (SА) (n = 52) and control group which consisted of individuals without HTN, SA, or coronary artery disease (n = 33). All groups matched by age and gender. All subjects underwent following examinations: ultrasonography of extracranial segments of carotid arteries, 24-hour blood pressure monitoring with the assessment of arterial stiffness parameters.Results. In subjects with HTN compared to controls, pulse wave velocity in aorta (PWVao) was significantly higher (11,3 ± 1,5; 12,3 ± 1,8 vs 10,4 ± 1,3 m/s; p < 0,05), as well as pulse pressure (PP) (46,4 ± 9,8; 45,6 ± 10,6 vs 39,9 ± 6,5 mmHg; p < 0,05), central pulse pressure (PPао) (35,5 ± 8,5; 34,9 ± 8,5 vs 30,9 ± 5,4 mmHg; p < 0,05), and arterial stiffness index (ASI) (141 (127, 159); 139 (128,5, 160,5) vs 126 (118, 138) mmHg; p < 0,05). In subjects with HTN and SA, PWVao was significantly higher compared to other groups (p < 0,05). No significant difference in augmentation index was found (–32,5 (–45, –12); –22 (–36, –12); –37 (–50, –17); p = 0,25). Аmbulatory arterial stiffness index was higher in controls (0,5 ± 0,2) compared to HTN group (0,4 ± 0,2; p = 0,05), while HTN and SA group did not differ significantly (0,5 ± 0,2; p = 0,3). PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection.Conclusions. In HTN patients, arterial stiffness is changed compared to healthy individuals. PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection. In patients with HTN and SA arterial stiffness is higher, which might have additional predictive value in risk stratification.

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Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

10.21203/rs.3.rs-31909/v1 ◽

2020 ◽

Author(s):

Minghui Li ◽

Aihua Zhan ◽

Xiao Huang ◽

Lihua Hu ◽

Wei Zhou ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Fasting Glucose ◽

Independent Predictor ◽

Positive Association ◽

Registry Study ◽

Hypertensive Patients ◽

Tyg Index ◽

Triglyceride Glucose Index ◽

Background Data

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients.Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively correlated with baPWV (β, 0.97; 95% confidence interval [CI] 0.78, 1.17). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.03; 95% CI 1.70, 2.41). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively correlated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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Treat to target and prevention of subclinical atherosclerosis in psoriatic arthritis—which target should we choose?

Rheumatology ◽

10.1093/rheumatology/keaa025 ◽

2020 ◽

Vol 59 (10) ◽

pp. 2881-2892

Author(s):

Isaac T Cheng ◽

Edmund K Li ◽

Priscilla C Wong ◽

Mei Yan Law ◽

Isaac C Yim ◽

...

Keyword(s):

Arterial Stiffness ◽

Protective Effect ◽

Disease Activity ◽

Disease Control ◽

Subclinical Atherosclerosis ◽

Intima Media Thickness ◽

Treat To Target ◽

Vascular Effects ◽

Treatment Targets ◽

Media Thickness

Abstract Objective PsA patients who achieved sustained minimal disease activity (sMDA) had less subclinical atherosclerosis progression. The vascular effects of achieving other potential treatment targets, including the PsA Disease Activity Score (PASDAS) and the Disease Activity in PsA (DAPSA) score, remained uncertain. This study aimed to compare the vascular effects of achieving different treatment targets in PsA patients. Method This is a post hoc analysis of a 2 year treat-to-target study aimed at MDA. A total of 101 consecutive PsA patients without overt cardiovascular disease were recruited. High-resolution carotid ultrasound and arterial stiffness markers were assessed annually. Low disease activity (LDA) was defined as MDA, DAPSA ≤14 or PASDAS ≤3.2. Sustained disease control was defined as achieving these targets at each visit from month 12 until month 24. Results Ninety patients [52 male (57.8%), age 50 years (s.d. 11)] who completed 24 months of follow-up were included in this analysis. A total of 44%, 48% and 45% of patients achieved sustained DAPSA LDA (sDAPDA-LDA), sustained PASDAS LDA (sPASDAS-LDA) and sMDA, respectively. Patients who achieved sMDA had significantly less progression of carotid intima-media thickness than those who did not (P = 0.031). Using multivariate analysis, achieving sMDA and sPASDAS-LDA had a protective effect on plaque progression, less increase in total plaque area, reduced mean intima-media thickness and reduced augmentation index after adjusting for covariates. In contrast, no significant differences in the progression of vascular parameters were demonstrated between patients who did or did not achieve sDAPSA-LDA. Conclusion Achieving sMDA/sDASPAS-LDA, but not sDAPSA-LDA, was associated with a protective effect in subclinical atherosclerosis and arterial stiffness progression. A multidimensional domain of disease control might be better in minimizing cardiovascular risk in PsA.

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