scholarly journals How residual disease affects outcome after radical surgery for incidental gallbladder cancer

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e54-e55
Author(s):  
L. Gil ◽  
J. Lendoire ◽  
F. Duek ◽  
M. Massa ◽  
G. Raffin ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Residual Disease ◽  
Radical Surgery ◽  
Incidental Gallbladder Cancer

Radical Surgery for Incidental Gallbladder Cancer: The Value of a Deferred Pathological Finding of Residual Disease

2014 ◽  
Vol 92 (3) ◽  
pp. 168-174
Author(s):  
Luis Gil ◽  
Javier Lendoire ◽  
Fernando Duek ◽  
Carlos Quarin ◽  
Verónica Garay ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Residual Disease ◽  
Radical Surgery ◽  
Pathological Finding ◽  
Incidental Gallbladder Cancer

scholarly journals PREVALENCE OF INCIDENTAL GALLBLADDER CANCER IN A TERTIARY-CARE HOSPITAL FROM PERNAMBUCO, BRAZIL

2015 ◽  
Vol 52 (3) ◽  
pp. 247-249 ◽  
Author(s):  
Euclides Dias MARTINS-FILHO ◽  
Thales Paulo BATISTA ◽  
Flávio KREIMER ◽  
Antonio Cavalcanti de Albuquerque MARTINS ◽  
Tiago Cavalcanti IWANAGA ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Radical Surgery ◽  
Tumor Staging ◽  
Tertiary Care ◽  
Prevalence Estimate ◽  
Care Hospital ◽  
Repeat Surgery ◽  
Distal Cholangiocarcinoma ◽  
Whipple’S Procedure ◽  
Incidental Gallbladder Cancer

BackgroundGallbladder cancer is sometimes incidentally uncovered following cholecystectomy for gallstones diseases. The supposed highly variable prevalence of incidental gallbladder cancer through our country is unknown.ObjectiveTo explore the prevalence of incidental gallbladder cancer in our tertiary-care hospital.MethodsA cross-sectional study was carried out on patients who consecutively underwent cholecystectomy due to gallstones disease at Faculdade Pernambucana de Saúde, Instituto de Medicina Integral Professor Fernando Figueira - FPS/IMIP, from January, 2007 to December, 2010. Data on incidental gallbladder cancer patients were explored for prevalence estimation and description of our experience with the management of this malignancy.ResultsOur analysis involved 2018 patients with a marked predominance of women (n=1.697; 84.1%) over men (n=321; 15.9%). The 3-year prevalence estimate of 0.34% was recorded for incidental gallbladder cancer in our sample. Regarding tumor staging, there were 1 T1a, 1 T1b, and 5 T2 adenocarcinoma tumors. Laparoscopic cholecystectomy alone was performed for the T1a tumor, and additional radical surgery was performed in five others. One patient presented metastatic disease at the time of repeat surgery. The final pathology revealed residual/additional disease in all T2 tumors after radical surgery whereas the T1b patient underwent a salvage Whipple’s procedure due to a secondary distal cholangiocarcinoma. The patient with T1a tumor is alive after 3-year follow-up but all of the others died because of disease recurrence/progression up to 12 months.ConclusionThis study confirms the poor prognosis of Gallbladder cancer even when incidentally diagnosed following cholecystectomy and supposes a 3-year prevalence estimate of 0.34% for incidental gallbladder cancer in our Center from Pernambuco State, Brazil.

scholarly journals Reconsideration of Laparoscopic Cholecystectomy

ISRN Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Kazuhiko Kasuya ◽  
Takao Itoi ◽  
Takaaki Matsudo ◽  
Bunsoh Kyo ◽  
Yasushi Endo ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Gallbladder Cancer ◽  
Chronic Inflammation ◽  
Biliary Tract ◽  
Radical Surgery ◽  
Important Thing ◽  
Standard Operation ◽  
Incidental Gallbladder Cancer ◽  
Method Of Cases ◽  
Distended Gallbladder

We describe the surgical method of cases showing a distended gallbladder. Because the most important thing does not cause biliary tract injury, it is to find orientation carefully. The frequency of incidental gallbladder cancer was in 7 (0.7%) of the 983. Only cholecystectomy is necessary to be performed for Tis or T1 cancer, and surgery has to be changed to radical surgery for T2 cancer or deeper invasion. Laparoscopic cholecystectomy is already an established standard operation. In the presence of acute or severe chronic inflammation, special attention should be paid to these points.

scholarly journals Predicting Residual Disease in Incidental Gallbladder Cancer: Risk Stratification for Modified Treatment Strategies

2017 ◽  
Vol 21 (8) ◽  
pp. 1254-1261 ◽  
Author(s):  
John M. Creasy ◽  
Debra A. Goldman ◽  
Mithat Gonen ◽  
Vikas Dudeja ◽  
Gokce Askan ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Risk Stratification ◽  
Gallbladder Cancer ◽  
Residual Disease ◽  
Treatment Strategies ◽  
Incidental Gallbladder Cancer

scholarly journals Prognostic value and risk stratification of residual disease in patients with incidental gallbladder cancer

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Emilio Ramos ◽  
Nuria Lluis ◽  
Laura Llado ◽  
Jaume Torras ◽  
Juli Busquets ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Gallbladder Cancer ◽  
Prognostic Value ◽  
Residual Disease ◽  
Incidental Gallbladder Cancer

Incidental Gallbladder Cancer: How Residual Disease Affects Outcome in Two Referral HPB Centers from South America

2018 ◽  
Vol 43 (1) ◽  
pp. 214-220 ◽  
Author(s):  
Luis Gil ◽  
Xabier de Aretxabala ◽  
Javier Lendoire ◽  
Fernando Duek ◽  
Juan Hepp ◽  
...  
Keyword(s):  
South America ◽  
Gallbladder Cancer ◽  
Residual Disease ◽  
Incidental Gallbladder Cancer

scholarly journals Residual disease in lymph nodes has no influence on survival in patients with incidental gallbladder cancer – institution experience with literature review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mihajlo Đokic ◽  
Urban Stupan ◽  
Sabina Licen ◽  
Blaz Trotovsek
Keyword(s):  
Lymph Node ◽  
Survival Rate ◽  
Lymph Nodes ◽  
Gallbladder Cancer ◽  
Lymph Node Metastases ◽  
Residual Disease ◽  
Treatment Strategies ◽  
Node Metastases ◽  
Incidental Gallbladder Cancer

Abstract Background A better appreciation of the course and factors that influence incidental gallbladder cancer (iGBC) is needed to develop treatment strategies aimed to improve outcomes. The purpose of the study was to determine the influence of residual disease in the liver and lymph nodes on overall survival in re-resected patients with iGBC. Patients and methods Patients undergoing radical re-resection for iGBC from January 2012 to December 2018 were retrospectively identified. Patients with a 5-year follow-up and submitted to complete resection with stage I, II and III disease were analysed. The influence of residual disease (RD) in liver and lymph nodes on survival was assessed using the Kaplan-Meier curves. In addition, the rest of the group was assessed based on type of primary/secondary procedure, number of harvested lymph nodes and RD in liver and/or lymph nodes. Results In this retrospective study 48 out of 58 (83%) patients underwent re-resection. Among the group with a 5-year follow-up (re-operation between 2012–2014), 22 patients out of 28 (79%) were re-resected. Survival analysis showed that patients with no RD in the liver and lymph nodes had statistically significant better 5-year survival than those with RD. Comparing 5-year survival rate in patients with RD in the liver or lymph nodes against no RD group, patients with RD in the liver had statistically significantly worse 5-year survival, while lymph node metastases did not show any statistically significant different in 5-year survival. Besides, a statistically significant better prognosis was found in stage II disease compared to stage III, as expected. Conclusions The most important predictors of a 5-year survival in our study were RD in liver and stage of the disease. Lymph node metastases did not have any impact on the overall 5-year survival rate.

scholarly journals Incidental gallbladder cancer: how residual disease affects outcome in two different South American referral centers

HPB ◽  
2017 ◽  
Vol 19 ◽  
pp. S49
Author(s):  
L. Gil ◽  
X. de Aretxabala ◽  
J. Lendoire ◽  
J. Hepp ◽  
O. Imventarza
Keyword(s):  
Gallbladder Cancer ◽  
Residual Disease ◽  
South American ◽  
Incidental Gallbladder Cancer

scholarly journals Re-resection in Incidental Gallbladder Cancer: Survival and the Incidence of Residual Disease

2019 ◽  
Vol 27 (4) ◽  
pp. 1132-1142 ◽  
Author(s):  
Elise A. J. de Savornin Lohman ◽  
Lydia G. van der Geest ◽  
Tessa J. J. de Bitter ◽  
Iris D. Nagtegaal ◽  
Cornelis J. H. M. van Laarhoven ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Nodes ◽  
Gallbladder Cancer ◽  
Residual Disease ◽  
Multivariable Analysis ◽  
Optimal Timing ◽  
R0 Resection ◽  
Significant Prognostic Factor ◽  
Netherlands Cancer Registry ◽  
Incidental Gallbladder Cancer

Abstract Background Re-resection for incidental gallbladder cancer (iGBC) is associated with improved survival but little is known about residual disease (RD) and prognostic factors. In this study, survival after re-resection, RD, and prognostic factors are analyzed. Methods Patients with iGBC were identified from the Netherlands Cancer Registry, and pathology reports of re-resected patients were reviewed. Survival and prognostic factors were analyzed. Results Overall, 463 patients were included; 24% (n = 110) underwent re-resection after a median interval of 66 days. RD was present in 35% of patients and was most frequently found in the lymph nodes (23%). R0 resection was achieved in 93 patients (92%). Median overall survival (OS) of patients without re-resection was 13.7 (95% confidence interval [CI] 11.6–15.6), compared with 52.6 months (95% CI 36.3–68.8) in re-resected patients (p < 0.001). After re-resection, median OS was superior in patients without RD versus patients with RD (not reached vs. 23.1 months; p < 0.001). In patients who underwent re-resection, RD in the liver (hazard ratio [HR] 5.54; p < 0.001) and lymph nodes (HR 2.35; p = 0.005) were the only significant prognostic factors in multivariable analysis. Predictive factors for the presence of RD were pT3 stage (HR 25.3; p = 0.003) and pN1 stage (HR 23.0; p = 0.022). Conclusion Re-resection for iGBC is associated with improved survival but remains infrequently used and is often performed after the optimal timing interval. RD is the only significant prognostic factor for survival after re-resection and can be predicted by pT and pN stages.

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