Impact of peripheral blood IL-18 gene early expression on kidney allograft long-term outcome

Poor peripheral blood stem cell (PBSC) mobilization predicts worse outcome for myeloma and lymphoma patients post autologous stem cell transplant (ASCT). We hypothesize that PBSC harvest using plerixafor and G-CSF in poor mobilizers may improve long-term outcome. We retrospectively analyzed the data on patients who had second PBSC mobilization using plerixafor and G-CSF as a rescue. Nine lymphoma and 8 multiple myeloma (MM) patients received the drug. A control group of 25 MM and lymphoma patients who were good mobilizers with G-CSF only was used for comparison. Sixteen of the 17 poor mobilizers proceeded to ASCT, and one MM patient had tandem transplants. Length of hospital stay, infection incidence, granulocyte engraftment, and long-term hematopoietic recovery were not significantly different between the two groups. In conclusion, all poor mobilizers were able to obtain adequate stem cells transplant dose and had similar transplant course and long-term outcome to that of the control good mobilizers group.

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7: Long-term outcome of methotrexate-free GVHD prophylaxis using sirolimus and tacrolimus in matched related (MRD) and unrelated donor (URD) peripheral blood stem cell transplantation (PBSCT)

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2006.12.010 ◽

2007 ◽

Vol 13 (2) ◽

pp. 5

Author(s):

C. Cutler ◽

S. Li ◽

V. Ho ◽

J. Koreth ◽

E. Alyea ◽

...

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Peripheral Blood ◽

Peripheral Blood Stem Cell ◽

Unrelated Donor ◽

Term Outcome ◽

Long Term Outcome ◽

Gvhd Prophylaxis ◽

Blood Stem Cell Transplantation

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Antiretroviral Therapy prior to Acute Viral Replication Preserves CD4 T Cells in the Periphery but Not in Rectal Mucosa during Acute Simian Immunodeficiency Virus Infection

Journal of Virology ◽

10.1128/jvi.01143-08 ◽

2008 ◽

Vol 82 (22) ◽

pp. 11467-11471 ◽

Cited By ~ 21

Author(s):

Muhamuda Kader ◽

Wail M. Hassan ◽

Matthew Eberly ◽

Michael Piatak ◽

Jeffrey D. Lifson ◽

...

Keyword(s):

T Cells ◽

Antiretroviral Therapy ◽

Peripheral Blood ◽

Cd4 T Cells ◽

Rectal Mucosa ◽

Term Outcome ◽

Long Term Outcome ◽

Immunodeficiency Virus ◽

Memory Cd4 T Cells

ABSTRACT The rectal mucosa is a major site for human immunodeficiency virus entry and CD4 T-cell depletion. The early and near-total loss of these cells from the rectal mucosa severely compromises the ability of the mucosal immune system to control various opportunistic infections. Protecting these cells from infection and destruction can delay disease progression, leading to a better long-term outcome. Here we show that effective suppression of viral infection in memory CD4 T cells from the rectal mucosa and peripheral blood to a very low level with antiretroviral therapy (ART) initiated prior to the peak of infection is associated with opposite outcomes in these tissues. A near-total loss of CD4 T cells in the rectal mucosa contrasted with preservation of most memory CD4 T cells in peripheral blood during the course of treatment. Interestingly, ART significantly reduced viral infection in memory CD4 T cells from both rectal mucosa and peripheral blood. Although early ART was of limited value in protecting the CD4 T cells in the rectal mucosa, the significant preservation of peripheral CD4 T cells could contribute to maintaining immune competence, leading to a better long-term outcome.

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