Fingolimod improves the functional recovery of optic pathway and alleviates the expression level of histone deacetylase/sphingosine 1 phosphate receptor 1 in focal demyelination model of rat's optic chiasm

OBJECT Visual impairments are the most common objective manifestations of suprasellar lesions. Diffusion tensor imaging (DTI) is a noninvasive MRI modality that depicts the subcortical white matter tracts in vivo. In this study the authors tested the value of visual pathway tractography in comparison with visual field and visual acuity analyses. METHODS This prospective study consisted of 25 patients with progressive visual impairment due to suprasellar mass lesions and 6 control patients with normal vision without such lesions. Visual acuity, visual field, and the optic fundus were examined preoperatively and repeated 1 week and 3 months after surgery. Visual pathway DTI tractography was performed preoperatively, intraoperatively immediately after tumor resection, and 1 week and 3 months after surgery. RESULTS In the control group, pre- and postoperative visual status were normal and visual pathway tractography revealed fibers crossing the optic chiasm without any alteration. In patients with suprasellar lesions, vision improved in 24 of 25. The mean distance between optic tracts in tractography decreased after tumor resection and detectable fibers crossing the optic chiasm increased from 12% preoperatively to 72% postoperatively 3 months after tumor resection, and undetectable fibers crossing the optic chiasm decreased from 88% preoperatively to 27% postoperatively 3 months after tumor resection. Visual improvement after tumor removal 1 week and 3 months after surgery was significantly correlated with the distance between optic tracts in intraoperative tractography (p < 0.01). CONCLUSIONS Visual pathway DTI tractography appears to be a promising adjunct to the standard clinical and paraclinical visual examinations in patients with suprasellar mass lesions. The intraoperative findings, in particular the distance between optic tract fibers, can predict visual outcome after tumor resection. Furthermore, postoperative application of this technique may be useful in following anterior optic pathway recovery.

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HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery

International Journal of Molecular Sciences ◽

10.3390/ijms21124539 ◽

2020 ◽

Vol 21 (12) ◽

pp. 4539

Author(s):

Sven Hendrix ◽

Selien Sanchez ◽

Elissia Ventriglia ◽

Stefanie Lemmens

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Valproic Acid ◽

Side Effects ◽

Histone Deacetylase ◽

Functional Recovery ◽

Hdac Inhibition ◽

Beneficial Effects ◽

Cord Injury ◽

Classically Activated

Pan-histone deacetylase (HDAC) inhibition with valproic acid (VPA) has beneficial effects after spinal cord injury (SCI), although with side effects. We focused on specific HDAC8 inhibition, because it is known to reduce anti-inflammatory mediators produced by macrophages (Mφ). We hypothesized that HDAC8 inhibition improves functional recovery after SCI by reducing pro-inflammatory classically activated Mφ. Specific HDAC8 inhibition with PCI-34051 reduced the numbers of perilesional Mφ as measured by histological analyses, but did not improve functional recovery (Basso Mouse Scale). We could not reproduce the published improvement of functional recovery described in contusion SCI models using VPA in our T-cut hemisection SCI model. The presence of spared fibers might be the underlying reason for the conflicting data in different SCI models.

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Modulating proteoglycan receptor PTPσ using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm

Molecular and Cellular Neuroscience ◽

10.1016/j.mcn.2019.103391 ◽

2019 ◽

Vol 99 ◽

pp. 103391 ◽

Cited By ~ 2

Author(s):

Parvin Niknam ◽

Mohammad Reza Raoufy ◽

Yaghoub Fathollahi ◽

Mohammad Javan

Keyword(s):

Functional Recovery ◽

Optic Chiasm

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Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-004-0976-x ◽

2005 ◽

Vol 56 (1) ◽

pp. 22-28 ◽

Cited By ~ 21

Author(s):

Jun Murakami ◽

Jun-ichi Asaumi ◽

Noriko Kawai ◽

Hidetsugu Tsujigiwa ◽

Yoshinobu Yanagi ◽

...

Keyword(s):

Oral Cancer ◽

Reverse Transcriptase ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Expression Level ◽

Telomerase Reverse Transcriptase ◽

Deacetylase Inhibitor

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Regression after subtotal resection of an optic pathway glioma in an adult without adjuvant therapy: case report

Journal of Neurosurgery ◽

10.3171/2017.12.jns172188 ◽

2019 ◽

Vol 130 (6) ◽

pp. 2005-2008

Author(s):

Eveline Teresa Hidalgo ◽

Michelle W. McQuinn ◽

Jeffrey H. Wisoff

Keyword(s):

Adjuvant Therapy ◽

Optic Tract ◽

Optic Chiasm ◽

Optic Pathway Glioma ◽

Subtotal Resection ◽

Optic Pathway ◽

Ophthalmological Examination ◽

Homonymous Hemianopsia ◽

Juvenile Pilocytic Astrocytoma ◽

Personality Changes

Optic pathway gliomas (OPGs) are relatively common and benign lesions in children; however, in adults these lesions are nearly always malignant and hold a very poor prognosis. In this report the authors present the case of an adult patient with a benign OPG who underwent subtotal resection without adjuvant therapy and has had no tumor progression for more than 20 years. A 50-year-old woman presented with a 2-year history of personality changes, weight gain, and a few months of visual disturbances. Ophthalmological evaluation showed incomplete right homonymous hemianopsia. MRI demonstrated a 2.5 × 2.5 × 2.5–cm enhancing left-sided lesion involving the hypothalamus with extension into the suprasellar cistern, extending along the left optic tract and anterior to the level of the optic chiasm. A biopsy procedure revealed a juvenile pilocytic astrocytoma. A subtotal resection of approximately 80% of the tumor was performed. Postoperatively, the patient experienced complete resolution of her personality changes, and her weight decreased back to baseline. Ophthalmological examination showed increased right homonymous hemianopsia. In the years following her surgery, there was a spontaneous decrease in tumor size without adjuvant therapy. The patient continues to have an excellent quality of life despite a visual field defect, and no further tumor growth has been observed.

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