Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm

OBJECT Visual impairments are the most common objective manifestations of suprasellar lesions. Diffusion tensor imaging (DTI) is a noninvasive MRI modality that depicts the subcortical white matter tracts in vivo. In this study the authors tested the value of visual pathway tractography in comparison with visual field and visual acuity analyses. METHODS This prospective study consisted of 25 patients with progressive visual impairment due to suprasellar mass lesions and 6 control patients with normal vision without such lesions. Visual acuity, visual field, and the optic fundus were examined preoperatively and repeated 1 week and 3 months after surgery. Visual pathway DTI tractography was performed preoperatively, intraoperatively immediately after tumor resection, and 1 week and 3 months after surgery. RESULTS In the control group, pre- and postoperative visual status were normal and visual pathway tractography revealed fibers crossing the optic chiasm without any alteration. In patients with suprasellar lesions, vision improved in 24 of 25. The mean distance between optic tracts in tractography decreased after tumor resection and detectable fibers crossing the optic chiasm increased from 12% preoperatively to 72% postoperatively 3 months after tumor resection, and undetectable fibers crossing the optic chiasm decreased from 88% preoperatively to 27% postoperatively 3 months after tumor resection. Visual improvement after tumor removal 1 week and 3 months after surgery was significantly correlated with the distance between optic tracts in intraoperative tractography (p < 0.01). CONCLUSIONS Visual pathway DTI tractography appears to be a promising adjunct to the standard clinical and paraclinical visual examinations in patients with suprasellar mass lesions. The intraoperative findings, in particular the distance between optic tract fibers, can predict visual outcome after tumor resection. Furthermore, postoperative application of this technique may be useful in following anterior optic pathway recovery.

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Modulating proteoglycan receptor PTPσ using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm

Molecular and Cellular Neuroscience ◽

10.1016/j.mcn.2019.103391 ◽

2019 ◽

Vol 99 ◽

pp. 103391 ◽

Cited By ~ 2

Author(s):

Parvin Niknam ◽

Mohammad Reza Raoufy ◽

Yaghoub Fathollahi ◽

Mohammad Javan

Keyword(s):

Functional Recovery ◽

Optic Chiasm

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Regression after subtotal resection of an optic pathway glioma in an adult without adjuvant therapy: case report

Journal of Neurosurgery ◽

10.3171/2017.12.jns172188 ◽

2019 ◽

Vol 130 (6) ◽

pp. 2005-2008

Author(s):

Eveline Teresa Hidalgo ◽

Michelle W. McQuinn ◽

Jeffrey H. Wisoff

Keyword(s):

Adjuvant Therapy ◽

Optic Tract ◽

Optic Chiasm ◽

Optic Pathway Glioma ◽

Subtotal Resection ◽

Optic Pathway ◽

Ophthalmological Examination ◽

Homonymous Hemianopsia ◽

Juvenile Pilocytic Astrocytoma ◽

Personality Changes

Optic pathway gliomas (OPGs) are relatively common and benign lesions in children; however, in adults these lesions are nearly always malignant and hold a very poor prognosis. In this report the authors present the case of an adult patient with a benign OPG who underwent subtotal resection without adjuvant therapy and has had no tumor progression for more than 20 years. A 50-year-old woman presented with a 2-year history of personality changes, weight gain, and a few months of visual disturbances. Ophthalmological evaluation showed incomplete right homonymous hemianopsia. MRI demonstrated a 2.5 × 2.5 × 2.5–cm enhancing left-sided lesion involving the hypothalamus with extension into the suprasellar cistern, extending along the left optic tract and anterior to the level of the optic chiasm. A biopsy procedure revealed a juvenile pilocytic astrocytoma. A subtotal resection of approximately 80% of the tumor was performed. Postoperatively, the patient experienced complete resolution of her personality changes, and her weight decreased back to baseline. Ophthalmological examination showed increased right homonymous hemianopsia. In the years following her surgery, there was a spontaneous decrease in tumor size without adjuvant therapy. The patient continues to have an excellent quality of life despite a visual field defect, and no further tumor growth has been observed.

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Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

PLoS ONE ◽

10.1371/journal.pone.0106378 ◽

2014 ◽

Vol 9 (9) ◽

pp. e106378 ◽

Cited By ~ 22

Author(s):

Fereshteh Pourabdolhossein ◽

Sabah Mozafari ◽

Ghislaine Morvan-Dubois ◽

Javad Mirnajafi-Zadeh ◽

Alejandra Lopez-Juarez ◽

...

Keyword(s):

Functional Recovery ◽

Optic Chiasm ◽

Nogo Receptor ◽

Receptor Inhibition

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Localization of protein kinase C isoforms in the optic pathway of mouse embryos and their role in axon routing at the optic chiasm

Brain Research ◽

10.1016/j.brainres.2014.05.027 ◽

2014 ◽

Vol 1575 ◽

pp. 22-32 ◽

Cited By ~ 4

Author(s):

Liqing Wang ◽

Joyce Shi-Ying Lam ◽

Hui Zhao ◽

Jun Wang ◽

Sun-On Chan

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Optic Chiasm ◽

Mouse Embryos ◽

Optic Pathway ◽

Kinase C ◽

Protein Kinase C Isoforms

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Malignant transformation of an optic pathway glioma without prior radiation therapy

Journal of Neurosurgery Pediatrics ◽

10.3171/2009.12.peds09173 ◽

2010 ◽

Vol 5 (5) ◽

pp. 507-510 ◽

Cited By ~ 23

Author(s):

Garrett K. Zoeller ◽

Carole D. Brathwaite ◽

David I. Sandberg

Keyword(s):

Radiation Therapy ◽

English Literature ◽

Optic Chiasm ◽

External Beam Radiation ◽

Optic Pathway Glioma ◽

Malignant Degeneration ◽

Low Grade ◽

Optic Pathway ◽

Beam Radiation ◽

First Case

Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and/or hypothalamus and most commonly occur in childhood. Although these tumors can be quite challenging to manage, they are typically low-grade astrocytomas histologically, most commonly pilocytic astrocytomas. The few previously reported cases of malignant degeneration of an OPG occurred after external beam radiation therapy. The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy.

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Vascular Compression of the Anterior Optic Pathway: A Rare Occurrence?

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2017.02.001 ◽

2017 ◽

Vol 68 (4) ◽

pp. 409-413 ◽

Cited By ~ 1

Author(s):

Satoshi Tsutsumi ◽

Hideo Ono ◽

Yukimasa Yasumoto

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Optic Chiasm ◽

Vascular Compression ◽

Optic Pathway ◽

Imaging Data ◽

Resonance Imaging ◽

Compressive Neuropathy ◽

Optic Pathways ◽

The Right

Background Vascular compression of the anterior optic pathway has been documented as an infrequent cause of visual impairments. Here we characterize such vascular compression using magnetic resonance imaging. Methods A total of 183 patients without pathologies affecting the optic pathways underwent T2-weighted or constructive interference steady-state sequence magnetic resonance imaging. Imaging data from coronal sections were analyzed. Results A vascular compression of the anterior optic pathway was identified in 20 patients (11%). They comprised 13 men and 7 women with a mean age of 60.8 years. The vascular compressions were observed at 22 sites, 15 on the optic nerve (ON) and 7 on the optic chiasm (OC). Twelve of them were on the right and 10 were on the left side. The offending vessels were the supraclinoid portion of the internal carotid artery in 86.4% and the A1 segment of the anterior cerebral artery in 13.6%. Compression sites at the ON and OC were variable, with the inferolateral surface being the most frequent (77.3% occurrences). In 2 patients (9.1%), the ON was compressed in a sandwich manner. Conclusions Vascular compression of the ON and OC may not be an infrequent occurrence in the cranial cavity. Progressive and unexplainable visual impairment might possibly be caused by vascular-compressive neuropathy.

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