scholarly journals Feedback Control and Synthetic Biology: Constraints on Design 1 1H.C.B. Steel would like to acknowledge the General Sir John Monash foundation for partial financial support of this work. A. Papachristodoulou was supported in part by EP/M002454/1.

2017 ◽  
Vol 50 (1) ◽  
pp. 10932-10937
Author(s):  
Harrison C.B. Steel ◽  
Antonis Papachristodoulou
2021 ◽  
Author(s):  
Auguste Gires ◽  
Ioulia Tchiguirinskaia ◽  
Daniel Schertzer

<p>Universal Multifractals have been widely used to characterize and simulate geophysical fields extremely variable over a wide range of scales such as rainfall. Despite strong limitations, notably its non-stationnarity, discrete cascades are often used to simulate such fields. Recently, blunt cascades have been introduced in 1D and 2D to cope with this issue while remaining in the simple framework of discrete cascades. It basically consists in geometrically interpolating over moving windows the multiplicative increments at each cascade steps.</p><p> </p><p>In this paper, we first suggest an extension of this blunt cascades to space-time processes. Multifractal expected behaviour is theoretically established and numerically confirmed. In a second step, a methodology to address the common issue of guessing the missing half of a field is developed using this framework. It basically consists in reconstructing the increments of the known portion of the field, and then stochastically simulating the ones for the new portion, while ensuring the blunting the increments on the portion joining the two parts of the fields. The approach is tested with time series, maps and in a space-time framework. Initial tests with rainfall data are presented.</p><p> </p><p>Authors acknowledge the RW-Turb project (supported by the French National Research Agency - ANR-19-CE05-0022), for partial financial support.</p>


2016 ◽  
Vol 13 (120) ◽  
pp. 20160380 ◽  
Author(s):  
Domitilla Del Vecchio ◽  
Aaron J. Dy ◽  
Yili Qian

The past several years have witnessed an increased presence of control theoretic concepts in synthetic biology. This review presents an organized summary of how these control design concepts have been applied to tackle a variety of problems faced when building synthetic biomolecular circuits in living cells. In particular, we describe success stories that demonstrate how simple or more elaborate control design methods can be used to make the behaviour of synthetic genetic circuits within a single cell or across a cell population more reliable, predictable and robust to perturbations. The description especially highlights technical challenges that uniquely arise from the need to implement control designs within a new hardware setting, along with implemented or proposed solutions. Some engineering solutions employing complex feedback control schemes are also described, which, however, still require a deeper theoretical analysis of stability, performance and robustness properties. Overall, this paper should help synthetic biologists become familiar with feedback control concepts as they can be used in their application area. At the same time, it should provide some domain knowledge to control theorists who wish to enter the rising and exciting field of synthetic biology.


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